Functional impact of CYFIP2 RNA editing on actin regulation, axon growth, and spinogenesis

  1. Luca La Via
  2. Elona Ndoj
  3. Matteo Bertoli
  4. Veronica Mutti
  5. Giulia Carini
  6. Alice Filippini
  7. Federica Bono
  8. Chiara Fiorentini
  9. Giovanni Ribaudo
  10. Alessandra Gianoncelli
  11. Giuseppe Borsani
  12. Isabella Russo
  13. Alessandro Barbon

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  1. Version published to 10.1016/j.neuint.2025.106084
  2. Arcadia Science

    Curious if CYFIP2 can be tagged while maintaining integrity of the WRC and if so, if there would be any difference in the efficiency of proper localization/targeting of the K vs E variants in your WT knockdown/overexpression context (either in differentiated SH-SY5Y cells or primary neurons).

    There does seem to loss of global polarity in CYFIP2 KO cells -- do you know if there are differences in the microtubule cytoskeleton/MTOC positioning in CYFIP2 KOs?

    Both these questions are kind of getting at whether there are other novel/unexpected functions of CYFIP2 or effects of their variants than what we would expect solely related to WRC integrity/activity.

  3. Version published to 10.1101/2025.03.04.641430 on bioRxiv