Usefulness of real-time RT-PCR to understand the kinetics of SARS-CoV-2 in blood: A prospective study
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SciScore for 10.1101/2022.03.07.22271764: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: All patients gave their informed consent, and the research protocol was approved by the Institutional Ethics Review Board (register number 4267).
IRB: All patients gave their informed consent, and the research protocol was approved by the Institutional Ethics Review Board (register number 4267).Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences …SciScore for 10.1101/2022.03.07.22271764: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: All patients gave their informed consent, and the research protocol was approved by the Institutional Ethics Review Board (register number 4267).
IRB: All patients gave their informed consent, and the research protocol was approved by the Institutional Ethics Review Board (register number 4267).Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:The present study has certain limitations. First, the number of patients included in the study was moderate (57 patients). Second, although two RT-PCR techniques were performed, only the TapPath™ test allowed us to quantify the viral load (in copies/ml and log10 viral load). In summary, we conclude that persistent SARS-CoV-2 viremia in blood samples may be potentially used as indicator of poor prognosis in hospitalised COVID-19 patients. Both qualitative and quantitative RT-PCR techniques are suitable for the characterisation of viremia kinetics in plasma and serum samples. Knowledge of SARS-CoV-2 kinetics in blood allows stratification of hospitalised COVID-19 patients.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- No funding statement was detected.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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