Vaccine effectiveness of ChAdOx1 nCoV-19 against COVID-19 in a socially vulnerable community in Rio de Janeiro, Brazil: a test-negative design study
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SciScore for 10.1101/2021.10.16.21265095: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: This study was approved by the National Research Ethics Committee (IRB/CONEP) (CAAE - 49726921.6.0000.5248). Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study has some limitations. First, we could not evaluate second dose effectiveness and waning because of the vaccination campaign and enough follow-up. …
SciScore for 10.1101/2021.10.16.21265095: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: This study was approved by the National Research Ethics Committee (IRB/CONEP) (CAAE - 49726921.6.0000.5248). Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study has some limitations. First, we could not evaluate second dose effectiveness and waning because of the vaccination campaign and enough follow-up. Second, data on genome sequencing from all test-positives was not available. However, our study analyzed data in a period of high transmission rates of the Gamma and Delta variants in the community. Third, we could not evaluate the vaccine effectiveness for preventing COVID-19 hospitalizations or severe outcomes. Finally, although we excluded previous confirmed infections, it is expected that the community has a high attack rate and so the unvaccinated could have an unmeasured protection level, underestimating the vaccine effectiveness. One-dose of ChAdOx1 was effective on reducing symptomatic COVID-19 in using data from a community surveillance program, where there was a broad testing strategy without any cost to an overall young vulnerable population in a group of favelas in Brazil.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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