Ecological specialization and admixture drive the genomic and phenotypic diversity in Yarrowia lipolytica

  1. Sergio Izquierdo-Gea
  2. Javier Vicente
  3. Tomás A. Peña
  4. Pablo Villarreal
  5. Francisco A. Cubillos
  6. Cécile Neuvéglise
  7. Jorge Barriuso
  8. Ignacio Belda
  9. Javier Ruiz

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Abstract

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  1. Version published to 10.1016/j.celrep.2026.117163
  2. Arcadia Science

    The majority of conditions were evaluated through liquid cultures in microplate growth assays

    In future work, it would be useful to collect brightfield/DIC microscopy data for these strains to examine the ratio of spherical to filamentous cells in these diverse environmental conditions.

  3. Arcadia Science

    Of the 126 Y. lipolytica strains analyzed, 67 were newly sequenced in this study.

    This is an invaluable expansion of genetic information! I think it would be neat to highlight the 67 newly sequenced strains in Figure 1 to emphasize your contributions.

  4. Arcadia Science

    Eur2/Dairy strains

    It's interesting to see that one of these grows relatively well in the presence of cycloheximide. It might be neat to dig into this strain more with additional phenotypic characterization and exploration of what's conferring this fitness.

  5. Version published to 10.1101/2025.11.28.690175 on bioRxiv