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  1. Cellular reprogramming of human monocytes is regulated by time-dependent IL4 signalling and NCOR2

    This article has 37 authors:
    1. Jil Sander
    2. Susanne V. Schmidt
    3. Branko Cirovic
    4. Naomi McGovern
    5. Olympia Papantonopoulou
    6. Anna-Lena Hardt
    7. Anna C. Aschenbrenner
    8. Christoph Kreer
    9. Kreer Quast
    10. Alexander M. Xu
    11. Lisa M. Schmidleithner
    12. Heidi Theis
    13. Thi Huong Lan Do
    14. Hermi Rizal Bin Sumatoh
    15. Mario A. R. Lauterbach
    16. Jonas Schulte-Schrepping
    17. Patrick Gunther
    18. Jia Xue
    19. Kevin Baßler
    20. Thomas Ulas
    21. Kathrin Klee
    22. Stefanie Herresthal
    23. Wolfgang Krebs
    24. Bianca Martin
    25. Eicke Latz
    26. Kristian Händler
    27. Michael Kraut
    28. Waldemar Kolanus
    29. Marc Beyer
    30. Christine S. Falk
    31. Bettina Wiegmann
    32. Sven Burgdorf
    33. Nicholas A. Melosh
    34. Evan W. Newell
    35. Florent Ginhoux
    36. Andreas Schlitzer
    37. Joachim L. Schultze
    This article has no evaluationsAppears in 1 listLatest version
  2. Platelets Fuel the Inflammasome Activation of Innate Immune Cells

    This article has 21 authors:
    1. Verena Rolfes
    2. Lucas Secchim Ribeiro
    3. Ibrahim Hawwari
    4. Lisa Böttcher
    5. Nathalia Rosero
    6. Salie Maasewerd
    7. Marina Lima Silva Santos
    8. Tomasz Próchnicki
    9. Camila Meirelles de Souza Silva
    10. Carlos Wagner de Souza Wanderley
    11. Maximilian Rothe
    12. Susanne V. Schmidt
    13. H. James Stunden
    14. Damien Bertheloot
    15. Magali Noval Rivas
    16. Cor Jesus Fontes
    17. Luzia Helena Carvalho
    18. Fernando Queiroz Cunha
    19. Eicke Latz
    20. Moshe Arditi
    21. Bernardo Simoes Franklin
    This article has no evaluationsAppears in 1 listLatest version
  3. BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity

    This article has 32 authors:
    1. Zsófia Agnes Bittner
    2. Xiao Liu
    3. Maria Mateo Tortola
    4. Ana Tapia-Abellán
    5. Sangeetha Shankar
    6. Liudmila Andreeva
    7. Matthew Mangan
    8. Marianne Spalinger
    9. Hubert Kalbacher
    10. Peter Düwell
    11. Marta Lovotti
    12. Karlotta Bosch
    13. Sabine Dickhöfer
    14. Ana Marcu
    15. Stefan Stevanović
    16. Franziska Herster
    17. Yamel Cardona Gloria
    18. Tzu-Hsuan Chang
    19. Francesca Bork
    20. Carsten L. Greve
    21. Markus W. Löffler
    22. Olaf-Oliver Wolz
    23. Nadine A. Schilling
    24. Jasmin B. Kümmerle-Deschner
    25. Samuel Wagner
    26. Anita Delor
    27. Bodo Grimbacher
    28. Oliver Hantschel
    29. Michael Scharl
    30. Hao Wu
    31. Eicke Latz
    32. Alexander N.R. Weber

    Reviewed by preLights

    This article has 1 evaluationAppears in 2 listsLatest version Latest activity
  4. IRAK1-mediated coincidence detection of microbial signals licenses inflammasome activation

    This article has 18 authors:
    1. Sharat J. Vayttaden
    2. Margery Smelkinson
    3. Orna Ernst
    4. Rebecca J. Carlson
    5. Jing Sun
    6. Clinton Bradfield
    7. Michael G. Dorrington
    8. Jonathan Liang
    9. Nicolas Bouladoux
    10. Rachel A. Gottschalk
    11. Kyu-Seon Oh
    12. Gianluca Pegoraro
    13. Sundar Ganesan
    14. Dominic De Nardo
    15. Eicke Latz
    16. Yasmine Belkaid
    17. Rajat R. Varma
    18. Iain D.C. Fraser
    This article has no evaluationsAppears in 1 listLatest version
  5. Sensing soluble uric acid by Naip1-Nlrp3 platform

    This article has 19 authors:
    1. Tarcio Teodoro Braga
    2. Mariana Rodrigues Davanso
    3. Davi Mendes
    4. Tiago Antonio de Souza
    5. Anderson Fernandes de Brito
    6. Mario Costa Cruz
    7. Meire Ioshie Hiyane
    8. Dhemerson Souza de Lima
    9. Vinicius Nunes
    10. Juliana de Fátima Giarola
    11. Denio Emanuel Pires Souto
    12. Tomasz Próchnicki
    13. Mario Lauterbach
    14. Stellee Marcela Petris Biscaia
    15. Rilton Alves de Freitas
    16. Rui Curi
    17. Alessandra Pontillo
    18. Eicke Latz
    19. Niels Olsen Saraiva Camara
    This article has no evaluationsAppears in 1 listLatest version
  6. The ASC inflammasome adapter controls the extent of peripheral protein aggregate deposition in inflammation-associated amyloidosis

    This article has 22 authors:
    1. Marco Losa
    2. Marc Emmenegger
    3. Pierre De Rossi
    4. Patrick M Schürch
    5. Tetiana Serdiuk
    6. Niccolò Pengo
    7. Danaëlle Capron
    8. Dimitri Bieli
    9. Niels J Rupp
    10. Manfredi C Carta
    11. Karl J Frontzek
    12. Veronika Lysenko
    13. Regina R Reimann
    14. Asvin KK Lakkaraju
    15. Mario Nuvolone
    16. Gunilla T Westermark
    17. K. Peter R. Nilsson
    18. Magdalini Polymenidou
    19. Alexandre P. A. Theocharides
    20. Simone Hornemann
    21. Paola Picotti
    22. Adriano Aguzzi

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  7. Activation of cGAS/STING pathway upon paramyxovirus infection

    This article has 15 authors:
    1. Mathieu Iampietro
    2. Claire Dumont
    3. Cyrille Mathieu
    4. Julia Spanier
    5. Jonathan Robert
    6. Aude Charpenay
    7. Sébastien Dupichaud
    8. Kévin P. Dhondt
    9. Noémie Aurine
    10. Rodolphe Pelissier
    11. Marion Ferren
    12. Stéphane Mély
    13. Denis Gerlier
    14. Ulrich Kalinke
    15. Branka Horvat
    This article has no evaluationsAppears in 1 listLatest version
  8. SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway

    This article has 6 authors:
    1. Shahanshah Khan
    2. Mahnoush S Shafiei
    3. Christopher Longoria
    4. John W Schoggins
    5. Rashmin C Savani
    6. Hasan Zaki
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      The identification of a novel role of the spike protein expressed on SARS-CoV-2 in directly evoking the host inflammatory responses has a substantial impact in understanding the molecular mechanism of COVID-19 pathogenesis, which may have implication for development of new therapeutics. The elegant analytic approach conducted herein justifies the major conclusions of this work though several additional steps can be made to validate these claims.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife, ScreenIT

    This article has 6 evaluationsAppears in 4 listsLatest version Latest activity
  9. The RNA sensor MDA5 detects SARS-CoV-2 infection

    This article has 10 authors:
    1. Natalia G. Sampaio
    2. Lise Chauveau
    3. Jonny Hertzog
    4. Anne Bridgeman
    5. Gerissa Fowler
    6. Jurgen P. Moonen
    7. Maeva Dupont
    8. Rebecca A. Russell
    9. Marko Noerenberg
    10. Jan Rehwinkel

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 2 listsLatest version Latest activity
  10. Hyperinflammation evokes different antiviral TMPRSS2 and ADAM17 expression responses in human gut xenograft versus host mouse gut although overall genomic responses are similar

    This article has 15 authors:
    1. Lorna Morris
    2. Einat Nisim-Eliraz
    3. Iftach Schouten
    4. François Bergey
    5. Nigel Dyer
    6. Hiroshi Momiji
    7. Eilam Nir
    8. Noga Marsiano
    9. Raheleh Sheibani Tezerji
    10. Simcha Yagel
    11. Philip Rosenstiel
    12. David Rand
    13. Vitor A.P. Martins dos Santos
    14. Nahum Y. Shpigel
    15. SysmedIBD research consortium
    This article has no evaluationsAppears in 1 listLatest version