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  1. RIG-I activation primes and trains innate antiviral immune memory

    This article has 22 authors:
    1. Maike S Adamson
    2. Svetozar Nesic
    3. Andreas Buness
    4. Kübra Bayrak
    5. Saskia Schmitz
    6. Sofía Soler
    7. Thomas Zillinger
    8. Samira Marx
    9. Silke Lambing
    10. Katarzyna Andryka-Cegielski
    11. Fawad Khan
    12. Thais M. Schlee-Guimarães
    13. Stephan Herberhold
    14. Michele Proietti
    15. Katarzyna Placek
    16. Patrick Reading
    17. Luca Cicin-Sain
    18. Martin Schlee
    19. Jasper van den Boorn
    20. Evelyn Hartmann
    21. Gunther Hartmann
    22. Eva Bartok
    This article has no evaluationsAppears in 1 listLatest version
  2. Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat

    This article has 14 authors:
    1. Mengyao Wang
    2. Yu Qi
    3. Yutao Cao
    4. Xiaosheng Zhang
    5. Yongsheng Wang
    6. Qingyou Liu
    7. Jinlong Zhang
    8. Guangbin Zhou
    9. Yue Ai
    10. Shao Wei
    11. Linli Wang
    12. Guoshi Liu
    13. Zhengxing Lian
    14. Hongbing Han
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      This study is of interest to animal geneticists studying molecular breeding for infection resistance. The authors provide substantial new insight into the generation of a goat expressing domain fusion receptor TLR2-4, and clarify the mechanism to effectively eliminate S. aureus in macrophages from the gene-edited goat. Taken together, their findings suggest that TLR2-4 knock-in goats can serve as a good animal model for disease resistance breeding.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

    Reviewed by eLife

    This article has 4 evaluationsAppears in 3 listsLatest version Latest activity
  3. Revealing druggable cryptic pockets in the Nsp1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallography

    This article has 9 authors:
    1. Alberto Borsatto
    2. Obaeda Akkad
    3. Ioannis Galdadas
    4. Shumeng Ma
    5. Shymaa Damfo
    6. Shozeb Haider
    7. Frank Kozielski
    8. Carolina Estarellas
    9. Francesco Luigi Gervasio
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      SARS-CoV-2 nonstructural protein (Nsp1) has emerged as an attractive target as it plays an important role in modulating the host and viral gene expression. This study describes multiple druggable sites in Nsp1. A 1.1Å co-crystal structure of Nsp1 with a fragment, together with computational studies, provides a framework for the rational design of potential antiviral candidates. This important study is methodologically convincing and will be of interest to researchers in the fields of structural virology and rational drug design.

    Reviewed by eLife, ScreenIT

    This article has 6 evaluationsAppears in 4 listsLatest version Latest activity
  4. Landscape of immune-related signatures induced by targeting of different epigenetic regulators in melanoma: implications for immunotherapy

    This article has 23 authors:
    1. Andrea Anichini
    2. Alessandra Molla
    3. Gabriella Nicolini
    4. Valentina E. Perotti
    5. Francesco Sgambelluri
    6. Alessia Covre
    7. Carolina Fazio
    8. Maria Fortunata Lofiego
    9. Anna Maria di Giacomo
    10. Sandra Coral
    11. Antonella Manca
    12. Maria Cristina Sini
    13. Marina Pisano
    14. Teresa Noviello
    15. Francesca Caruso
    16. Silvia Brich
    17. Giancarlo Pruneri
    18. Andrea Maurichi
    19. Mario Santinami
    20. Michele Ceccarelli
    21. Giuseppe Palmieri
    22. Michele Maio
    23. Roberta Mortarini
    This article has no evaluationsAppears in 1 listLatest version