Evaluated articles

Breaking the next Cryo-EM resolution barrier – Atomic resolution determination of proteins!

1. Ka Man Yip
2. Niels Fischer
3. Elham Paknia
4. Ashwin Chari
5. Holger Stark

Reviewed by preLights

Modulation of β-catenin levels is critical for cranial neural crest patterning and dispersal into first pharyngeal arch

1. Alok Javali
2. Vairavan Laxmanan
3. Dasaradhi Palakodeti
4. Ramkumar Sambasivan

Reviewed by preLights

Single cell analysis reveals immune cell–adipocyte crosstalk regulating the transcription of thermogenic adipocytes

1. Prashant Rajbhandari
2. Douglas Arneson
3. Sydney K Hart
4. In Sook Ahn
5. Graciel Diamante
6. Luis C Santos
7. Nima Zaghari
8. An-Chieh Feng
9. Brandon J Thomas
10. Laurent Vergnes
11. Stephen D Lee
12. Abha K Rajbhandari
13. Karen Reue
14. Stephen T Smale
15. Xia Yang
16. Peter Tontonoz

Reviewed by preLights

A subcellular atlas of Toxoplasma reveals the functional context of the proteome

1. Konstantin Barylyuk
2. Ludek Koreny
3. Huiling Ke
4. Simon Butterworth
5. Oliver M. Crook
6. Imen Lassadi
7. Vipul Gupta
8. Eelco Tromer
9. Tobias Mourier
10. Tim J. Stevens
11. Lisa M. Breckels
12. Arnab Pain
13. Kathryn S. Lilley
14. Ross F. Waller

Reviewed by preLights

Foldamers Reveal and Validate Novel Therapeutic Targets Associated with Toxic α-Synuclein Self-Assembly

1. Jemil Ahmed
2. Tessa C. Fitch
3. Courtney M. Donnelly
4. Johnson A. Joseph
5. Mikaela M. Bassil
6. Ahyun Son
7. Chen Zhang
8. Aurélie Ledreux
9. Scott Horowitz
10. Yan Qin
11. Daniel Paredes
12. Sunil Kumar

Reviewed by preLights

The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development

1. Trisha A. Macrae
2. Miguel Ramalho-Santos

Reviewed by preLights

Transparency in peer review: Exploring the content and tone of reviewers’ confidential comments to editors

1. Bridget C. O’Brien
2. Anthony R. Artino
3. Joseph A. Costello
4. Erik Driessen
5. Lauren A. Maggio

Reviewed by preLights

A hydraulic instability drives the cell death decision in the nematode germline

1. N. T. Chartier
2. A. Mukherjee
3. J. Pfanzelter
4. S. Fürthauer
5. B. T. Larson
6. A.W. Fritsch
7. M. Kreysing
8. F. Jülicher
9. S. W. Grill

Reviewed by preLights

Dram1 confers resistance to Salmonella infection

1. Samrah Masud
2. Rui Zhang
3. Tomasz K. Prajsnar
4. Annemarie H. Meijer

Reviewed by preLights

An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma

1. Rediet Zewdu
2. Elnaz Mirzaei Mehrabad
3. Kelley Ingram
4. Pengshu Fang
5. Katherine L. Gillis
6. Soledad A. Camolotto
7. Grace Orstad
8. Alex Jones
9. Michelle C. Mendoza
10. Benjamin T. Spike
11. Eric L. Snyder

• Curated by eLife

  Evaluation Summary:

  This manuscript greatly expands our understanding of an aggressive subtype of lung cancer. The author use in vivo cancer models and extensive analysis of the cancer cells states to uncover aspects of differentiation, drug responses and pathway activation. Findings of the study will help in the development of lineage-specific targeted therapies against cancers.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife, preLights

Small differences in learning speed for different food qualities can drive efficient collective foraging in ant colonies

1. F. B. Oberhauser
2. A. Koch
3. T. J. Czaczkes

Reviewed by preLights

RAD50 promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes

1. Ann-Kathrin Mehnert
2. Marco Prorocic
3. Annick Dujeancourt-Henry
4. Sebastian Hutchinson
5. Richard McCulloch
6. Lucy Glover

Reviewed by preLights

Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients

1. Jessica Furner-Pardoe
2. Blessing O Anonye
3. Ricky Cain
4. John Moat
5. Catherine A. Ortori
6. Christina Lee
7. David A. Barrett
8. Christophe Corre
9. Freya Harrison

Reviewed by preLights

Combinatorial mutagenesis of rapidly evolving residues yields super-restrictor antiviral proteins

1. Rossana Colón-Thillet
2. Emily Hsieh
3. Laura Graf
4. Richard N. McLaughlin
5. Janet M. Young
6. Georg Kochs
7. Michael Emerman
8. Harmit S. Malik

Reviewed by preLights

Open Science Saves Lives: Lessons from the COVID-19 Pandemic

1. Lonni Besançon
2. Nathan Peiffer-Smadja
3. Corentin Segalas
4. Haiting Jiang
5. Paola Masuzzo
6. Cooper Smout
7. Eric Billy
8. Maxime Deforet
9. Clémence Leyrat

Reviewed by ScreenIT, preLights

Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling

1. Pim J Huis in 't Veld
2. Vladimir A Volkov
3. Isabelle D Stender
4. Andrea Musacchio
5. Marileen Dogterom

Reviewed by preLights

Intraspecific variation in thermal tolerance differs between tropical and temperate fishes

1. J.J.H. Nati
2. M.B.S. Svendsen
3. S. Marras
4. S.S. Killen
5. J.F. Steffensen
6. D.J. McKenzie
7. P. Domenici

Reviewed by preLights

Oxygen supply capacity in animals evolves to meet maximum demand at the current oxygen partial pressure regardless of size or temperature

1. Brad A. Seibel
2. Curtis Deutsch

Reviewed by preLights

An atlas of cortical arealization identifies dynamic molecular signatures

1. Aparna Bhaduri
2. Carmen Sandoval-Espinosa
3. Marcos Otero-Garcia
4. Irene Oh
5. Raymund Yin
6. Ugomma C. Eze
7. Tomasz J. Nowakowski
8. Arnold R. Kriegstein

Reviewed by preLights

Higher temperatures generically favour slower-growing bacterial species in multispecies communities

1. Simon Lax
2. Clare I. Abreu
3. Jeff Gore

Reviewed by preLights