Evaluated articles

EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cells

1. B. van de Kooij
2. A. Schreuder
3. R.S. Pavani
4. V. Garzero
5. A. Van Hoeck
6. M. San Martin Alonso
7. D. Koerse
8. T.J. Wendel
9. E. Callen
10. J. Boom
11. H. Mei
12. E. Cuppen
13. A. Nussenzweig
14. H. van Attikum
15. S.M. Noordermeer

Reviewed by preLights

A single laccase acts as a key component of environmental sensing in a broad host range fungal pathogen

1. Nathaniel M. Westrick
2. Eddie G. Dominguez
3. Madeline Bondy
4. Christina M. Hull
5. Damon L. Smith
6. Mehdi Kabbage

Reviewed by preLights

Susceptible bacteria survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance

1. Marinelle Rodrigues
2. Parastoo Sabaeifard
3. Muhammed Sadik Yildiz
4. Laura Coughlin
5. Sara Ahmed
6. Cassie Behrendt
7. Xiaoyu Wang
8. Marguerite Monogue
9. Jiwoong Kim
10. Shuheng Gan
11. Xiaowei Zhan
12. Laura Filkins
13. Noelle S. Williams
14. Lora V. Hooper
15. Andrew Y. Koh
16. Erdal Toprak

Reviewed by preLights

Coxiella burnetii actively blocks IL-17-induced oxidative stress in macrophages

1. Tatiana M. Clemente
2. Leonardo Augusto
3. Rajendra K. Angara
4. Stacey D. Gilk

Reviewed by preLights

The antiviral effects of a MEK1/2 inhibitor promote tumor regression in a preclinical model of human papillomavirus infection-induced tumorigenesis

1. Adrian J. Luna
2. Jesse M. Young
3. Rosa T. Sterk
4. Virginie Bondu
5. Fred A. Schultz
6. Donna F. Kusewitt
7. Huining Kang
8. Michelle A. Ozbun

Reviewed by preLights

A survey of Rare Disease awareness among healthcare professionals and researchers in India

1. Laxmikant Vashishta
2. Purna Bapat
3. Yashodhara Bhattacharya
4. Mohua Chakraborty Choudhury
5. Narendra Chirmule
6. Susan D’Costa
7. Shilpa Jindani
8. Manohar Rao
9. Smritie Sheth

Reviewed by preLights

daf-42 is an evolutionarily young gene essential for dauer development in Caenorhabditis elegans

1. Daisy S. Lim
2. Jun Kim
3. Wonjoo Kim
4. Nari Kim
5. Sang-Hee Lee
6. Daehan Lee
7. Junho Lee

Reviewed by preLights

Complete male-to-female sex reversal in XY mice lacking the miR-17∼92 cluster

1. Alicia Hurtado
2. Irene Mota-Gómez
3. Miguel Lao
4. Francisca M. Real
5. Johanna Jedamzick
6. Miguel Burgos
7. Darío G. Lupiáñez
8. Rafael Jiménez
9. Francisco J. Barrionuevo

Reviewed by preLights

Phosphorylation controls spatial and temporal activities of motor‐PRC1 complexes to complete mitosis

1. Agata Gluszek‐Kustusz
2. Benjamin Craske
3. Thibault Legal
4. Toni McHugh
5. Julie PI Welburn

Reviewed by preLights

SQ3370, the first clinical click chemistry-activated cancer therapeutic, shows safety in humans and translatability across species

1. Sangeetha Srinivasan
2. Nathan A. Yee
3. Michael Zakharian
4. Maša Alečković
5. Amir Mahmoodi
6. Tri-Hung Nguyen
7. José M. Mejía Oneto

Reviewed by preLights

An intermembrane space protein facilitates completion of mitochondrial division in yeast

1. Olivia M. Connor
2. Srujan K. Matta
3. Jonathan R. Friedman

Reviewed by preLights

Embryo mechanics cartography: inference of 3D force atlases from fluorescence microscopy

1. Sacha Ichbiah
2. Fabrice Delbary
3. Alex McDougall
4. Rémi Dumollard
5. Hervé Turlier

Reviewed by preLights

Cell polarity linked to gravity sensing is generated by protein translocation from statoliths to the plasma membrane

1. Takeshi Nishimura
2. Shogo Mori
3. Hiromasa Shikata
4. Moritaka Nakamura
5. Yasuko Hashiguchi
6. Yoshinori Abe
7. Takuma Hagihara
8. Hiroshi Y. Yoshikawa
9. Masatsugu Toyota
10. Takumi Higaki
11. Miyo Terao Morita

Reviewed by preLights

Molecular evidence of anteroposterior patterning in adult echinoderms

1. L. Formery
2. P. Peluso
3. I. Kohnle
4. J. Malnick
5. J. R. Thompson
6. M. Pitel
7. K. R. Uhlinger
8. D. S. Rokhsar
9. D. R. Rank
10. C. J. Lowe

Reviewed by preLights, Arcadia Science

Spatial and single-cell transcriptomics reveal neuron-astrocyte interplay in long-term memory

1. Wenfei Sun
2. Zhihui Liu
3. Xian Jiang
4. Michelle B. Chen
5. Hua Dong
6. Jonathan Liu
7. Thomas C. Südhof
8. Stephen R. Quake

Reviewed by preLights

Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing

1. Fumiyuki Hatanaka
2. Keiichiro Suzuki
3. Kensaku Shojima
4. Jingting Yu
5. Yuta Takahashi
6. Akihisa Sakamoto
7. Javier Prieto
8. Maxim Shokhirev
9. Estrella Nuñez Delicado
10. Concepcion Rodriguez Esteban
11. Juan Carlos Izpisua Belmonte

Reviewed by preLights

Quantitative mapping of proteasome interactomes and substrates using ProteasomeID

1. Aleksandar Bartolome
2. Julia C Heiby
3. Domenico Di Fraia
4. Ivonne Heinze
5. Hannah Knaudt
6. Ellen Spaeth
7. Omid Omrani
8. Alberto Minetti
9. Maleen Hofmann
10. Joanna M Kirkpatrick
11. Therese Dau
12. Alessandro Ori

• Curated by eLife

  eLife assessment

  This study presents an important method and resource in cell lines and in mice for mass spectrometry-based identification of interactors of the proteasome, a multi-protein complex with a central role in protein turnover in almost all tissues and cell types. The method presented, including the experimental workflow and analysis pipeline, as well as the several lines of validation provided throughout, is convincing. Given the growing interest in protein aggregation and targeted protein degradation modalities, this work will be of interest to a broad spectrum of basic cell biologists and translational researchers.

Reviewed by eLife, preLights

Inhibition of Centrosome Clustering Reduces Cystogenesis and Improves Kidney Function in Autosomal Dominant Polycystic Kidney Disease

1. Tao Cheng
2. Aruljothi Mariappan
3. Ewa Langner
4. Kyuhwan Shim
5. Jay Gopalakrishnan
6. Moe R. Mahjoub

Reviewed by preLights

Phospho-seq: integrated, multi-modal profiling of intracellular protein dynamics in single cells

1. John D. Blair
2. Austin Hartman
3. Fides Zenk
4. Philipp Wahle
5. Giovanna Brancati
6. Carol Dalgarno
7. Barbara Treutlein
8. Rahul Satija

Reviewed by preLights

From policy to practice: Lessons learned from an open science funding initiative

1. Sonya B. Dumanis
2. Kristen Ratan
3. Souad McIntosh
4. Hetal V. Shah
5. Matt Lewis
6. Timothy H. Vines
7. Randy Schekman
8. Ekemini A. Riley

Reviewed by preLights