Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4

  1. Roxan A. Stephenson
  2. Jordy Sepulveda
  3. Kory R. Johnson
  4. Adrian Lita
  5. Jaanam Gopalakrishnan
  6. Dominic J. Acri
  7. Alexandra Beilina
  8. Linling Cheng
  9. Linda G. Yang
  10. Jessica T. Root
  11. Michael E. Ward
  12. Christian Combs
  13. William C. Skarnes
  14. Mark R. Cookson
  15. Han-Yu Shih
  16. Mioara Larion
  17. G. William Rebeck
  18. Priyanka S. Narayan

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Abstract

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  1. Version published to 10.1016/j.celrep.2025.115961
  2. preLights

    Excerpt

    Lipid metabolism is necessary to allow microglial transcriptional and functional changes caused by inflammation and genetic risk factor APOE4 in human iPSC model, making its modulation a possible target to treat various diseases.

  3. Version published to 10.1101/2024.04.11.589145 on bioRxiv