Evaluated articles

In vivo mapping of protein-protein interactions of schizophrenia risk factors generates an interconnected disease network

1. Daniel B. McClatchy
2. Susan B. Powell
3. John R. Yates

Reviewed by Review Commons

DNA replication in primary hepatocytes without the six-subunit ORC

1. Róża K Przanowska
2. Yuechuan Chen
3. Takayuki-Okano Uchida
4. Etsuko Shibata
5. Xiaoxiao Hao
6. Isaac Segura Rueda
7. Kate Jensen
8. Piotr Przanowski
9. Anthony Trimboli
10. Yoshiyuki Shibata
11. Gustavo Leone
12. Anindya Dutta

• Curated by eLife

  eLife Assessment

  This valuable descriptive manuscript builds on prior research showing that the elimination of Origin Recognition Complex (ORC) subunits does not halt DNA replication. The authors obtain solid data using various methods to genetically remove one or two ORC subunits from specific tissues and still observe replication. The replication appears to be primarily endoreduplication, indicating that ORC-independent replication may promote genome reduplication without mitosis. The mechanism behind this ORC-independent replication remains to be elucidated. The study and mutants described herein lay the groundwork for future research to explore how cells compensate for the absence of ORC and to develop functional approaches to investigate this process. The reviewers suggested the observations could be supported by additional experiments. This work will be of interest to those studying genome duplication and replication.

Reviewed by eLife, Review Commons

Capturing cell heterogeneity in representations of cell populations for image-based profiling using contrastive learning

1. Robert van Dijk
2. John Arevalo
3. Mehrtash Babadi
4. Anne E. Carpenter
5. Shantanu Singh

Reviewed by Review Commons

Toll-1-dependent immune evasion induced by fungal infection leads to cell loss in the Drosophila brain

1. Deepanshu N. D. Singh
2. Abigail R. E. Roberts
3. Xiaocui Wang
4. Guiyi Li
5. Enrique Quesada Moraga
6. David Alliband
7. Elizabeth Ballou
8. Hung-Ji Tsai
9. Alicia Hidalgo

Reviewed by Review Commons

A Lgr5-independent developmental lineage is involved in mouse intestinal regeneration

1. Maryam Marefati
2. Valeria Fernandez-Vallone
3. Morgane Leprovots
4. Gabriella Vasile
5. Frédérick Libert
6. Anne Lefort
7. Gilles Dinsart
8. Achim Weber
9. Jasna Jetzer
10. Marie-Isabelle Garcia
11. Gilbert Vassart

Reviewed by Review Commons

Mechanisms of cilia regeneration in Xenopus multiciliated epithelium in vivo

1. Venkatramanan G. Rao
2. Vignesharavind Subramanianbalachandar
3. Magdalena M. Magaj
4. Stefanie Redemann
5. Saurabh S. Kulkarni

Reviewed by Review Commons, Arcadia Science

An intestinal Sir2-HSF1-ATGL1 pathway regulates lipolysis in C. elegans

1. Milán Somogyvári
2. Saba Khatatneh
3. Gábor Hajdú
4. Bar Sotil
5. József Murányi
6. Csaba Sőti

Reviewed by Review Commons

Ca ²⁺ binding to Esyt is required to modulate membrane contact site density in Drosophila photoreceptors

1. Vaisaly R Nath
2. Harini Krishnan
3. Shirish Mishra
4. Padinjat Raghu

Reviewed by Review Commons

Interferon-Induced PARP14-Mediated ADP-Ribosylation in p62 Bodies Requires an Active Ubiquitin-Proteasome System

1. Rameez Raja
2. Banhi Biswas
3. Rachy Abraham
4. Hongrui Liu
5. Che-Yuan Chang
6. Hien Vu
7. Anthony K. L. Leung

Reviewed by PREreview, Review Commons

Bellymount-pulsed tracking: a novel approach for real-time in vivo imaging of Drosophila abdominal tissues

1. Shruthi Balachandra
2. Amanda A Amodeo

Reviewed by Review Commons

A substrate-interacting region of Parkin directs ubiquitination of the mitochondrial GTPase Miro1

1. Joanna Koszela
2. Anne Rintala-Dempsey
3. Giulia Salzano
4. Viveka Pimenta
5. Outi Kamarainen
6. Mads Gabrielsen
7. Aasna L. Parui
8. Gary S. Shaw
9. Helen Walden

Reviewed by Review Commons

MDM2 stabilization of Notch intracellular domain upon DNA damage plays a major role in non-small cell lung carcinoma response to platinum chemotherapy

1. Sara Bernardo
2. Quentin-Dominique Thomas
3. Maicol Mancini
4. Alba Santos
5. Sylvia Fenosoa Rasamizafy
6. Amina-Milissa Maacha
7. Anais Giry
8. Emilie Bousquet-Mur
9. Laura Papon
10. Marion Goussard
11. Christophe Fremin
12. Andrea Pasquier
13. María Rodríguez
14. Camille Travert
15. Jean-Louis Pujol
16. Laetitia K Linares
17. Lisa Heron-Milhavet
18. Alexandre Djiane
19. Irene Ferrer
20. Luis Paz-Ares
21. Xavier Quantin
22. Luis M Montuenga
23. Hélène Tourriere
24. Antonio Maraver

Reviewed by Review Commons

Circadian rhythms of macrophages are altered by the acidic tumor microenvironment

1. Amelia M Knudsen-Clark
2. Daniel Mwangi
3. Juliana Cazarin
4. Kristina Morris
5. Cameron Baker
6. Lauren M Hablitz
7. Matthew N McCall
8. Minsoo Kim
9. Brian J Altman

Reviewed by Review Commons

Bilateral regulation of EGFR activity and local PI(4,5)P2 dynamics in mammalian cells observed with superresolution microscopy

1. Mitsuhiro Abe
2. Masataka Yanagawa
3. Michio Hiroshima
4. Toshihide Kobayashi
5. Yasushi Sako

Reviewed by Review Commons

BiP/GRP78 is a pro-viral factor for diverse dsDNA viruses that promotes the survival and proliferation of cells upon KSHV infection

1. Guillermo Najarro
2. Kevin Brackett
3. Hunter Woosley
4. Leah C. Dorman
5. Vincent Turon-Lagot
6. Sudip Khadka
7. Catya Faeldonea
8. Osvaldo Kevin Moreno
9. Adriana Ramirez Negron
10. Christina Love
11. Ryan Ward
12. Charles Langelier
13. Frank McCarthy
14. Carlos Gonzalez
15. Joshua E. Elias
16. Brooke M. Gardner
17. Carolina Arias

Reviewed by Review Commons

ACE2-independent sarbecovirus cell entry is supported by TMPRSS2-related enzymes and reduces sensitivity to antibody-mediated neutralization

1. Lu Zhang
2. Hsiu-Hsin Cheng
3. Nadine Krüger
4. Bojan Hörnich
5. Luise Graichen
6. Alexander S. Hahn
7. Sebastian R. Schulz
8. Hans-Martin Jäck
9. Metodi V. Stankov
10. Georg M.N. Behrens
11. Marcel A. Müller
12. Christian Drosten
13. Onnen Mörer
14. Martin Sebastian Winkler
15. ZhaoHui Qian
16. Stefan Pöhlmann
17. Markus Hoffmann

Reviewed by Review Commons

Activation of the mitochondrial unfolded protein response regulates the formation of stress granules

1. Marta Lopez-Nieto
2. Zhaozhi Sun
3. Emily Relton
4. Rahme Safakli
5. Brian D. Freibaum
6. J Paul Taylor
7. Alessia Ruggieri
8. Ioannis Smyrnias
9. Nicolas Locker

Reviewed by Review Commons

Late killing of Plasmodium berghei sporozoites in the liver by an anti-circumsporozoite protein antibody

1. Manuela C Aguirre-Botero
2. Olga Pacios
3. Susanna Celli
4. Eduardo Aliprandini
5. Anisha Gladston
6. Jean-Michel Thiberge
7. Pauline Formaglio
8. Rogerio Amino

• Curated by eLife

  eLife Assessment

  This important study shows that a monoclonal antibody against the repetitive region of the circumsporozoite protein (CSP) of the Malaria-causing parasite P. berghei has neutralizing activity on parasite invasion and development. The authors present convincing in vivo data confirming previous in vitro work, that suggested the intracellular post -invasion effect for this antibody. The findings offer insights into the inhibitory action of this anti-CSP antibody, which could inform the development of more effective malaria vaccines and therapeutic antibodies."

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

RBM39 shapes innate immunity through transcriptional and splicing control of key factors of the interferon response

1. Teng-Feng Li
2. Paul Rothhaar
3. Arthur Lang
4. Oliver Grünvogel
5. Ombretta Colasanti
6. Santa Mariela Olivera Ugarte
7. Jannik Traut
8. Antonio Piras
9. Nelson Acosta-Rivero
10. Vladimir Gonçalves Magalhães
11. Emely Springer
12. Andreas Betz
13. Hao-En Huang
14. Jeongbin Park
15. Ruiyue Qiu
16. Gnimah Eva Gnouamozi
17. Ann-Kathrin Mehnert
18. Viet Loan Dao Thi
19. Stephan Urban
20. Martina Muckenthaler
21. Matthias Schlesner
22. Dirk Wohlleber
23. Marco Binder
24. Ralf Bartenschlager
25. Andreas Pichlmair
26. Volker Lohmann

Reviewed by Review Commons

Resistance to PSEN1-selective γ-secretase inhibitors in T-cell acute lymphoblastic leukemia

1. Charlien Vandersmissen
2. Sofie Demeyer
3. Kris Jacobs
4. Lien Boogaerts
5. Sara Gutiérrez Fernández
6. Heidi Segers
7. Lucía Chávez-Gutiérrez
8. Jan Cools

Reviewed by Review Commons