Evaluated articles

Deep mutational scanning of EccD ₃ reveals the molecular basis of its essentiality in the mycobacterium ESX secretion system

1. Donovan D. Trinidad
2. Christian B. Macdonald
3. Oren S. Rosenberg
4. James S. Fraser
5. Willow Coyote-Maestas

Reviewed by Review Commons

Membrane microdomains are crucial for Mycobacterium marinum EsxA-dependent membrane damage, escape to the cytosol and infection

1. Cristina Bosmani
2. Angélique Perret
3. Florence Leuba
4. Aurélie Guého
5. Nabil Hanna
6. Thierry Soldati

Reviewed by Review Commons

An interbacterial cysteine protease toxin inhibits cell growth by targeting type II DNA topoisomerases GyrB and ParE

1. Pin-Yi Song
2. Chia-En Tsai
3. Yung-Chih Chen
4. Yu-Wen Huang
5. Po-Pang Chen
6. Tzu-Haw Wang
7. Chao-Yuan Hu
8. Po-Yin Chen
9. Chuan Ku
10. Kuo-Chiang Hsia
11. See-Yeun Ting

Reviewed by Review Commons

Clu1/Clu form mitochondria-associated granules upon metabolic transitions and regulate mitochondrial protein translation via ribosome interactions

1. Leonor Miller-Fleming
2. Wing Hei Au
3. Laura Raik
4. Pedro Rebelo-Guiomar
5. Jasper Schmitz
6. Ha Yoon Cho
7. Aron Czako
8. Alexander J. Whitworth

Reviewed by Review Commons

Intestinal fibroblast heterogeneity: unifying RNA-seq studies and introducing consensus-driven nomenclature

1. Neda Glisovic
2. Aleksandra Chikina
3. Noémie Robil
4. Sonia Lameiras
5. Danijela Matic Vignjevic

Reviewed by Review Commons

Conserved interhemispheric morphogenesis in amniotes preceded the evolution of the corpus callosum

1. Ryota Noji
2. Mari Kaneko
3. Takaya Abe
4. Hiroshi Kiyonari
5. Yukihiro Nishikawa
6. Takuma Kumamoto
7. Hitoshi Gotoh
8. Chiaki Ohtaka-Maruyama
9. Katsuhiko Ono
10. Tatsuya Yoshizawa
11. Tadashi Nomura

Reviewed by Review Commons

Chromokinesin Klp-19 regulates microtubule overlap and dynamics during anaphase in C. elegans

1. Vitaly Zimyanin
2. Magdalena Magaj
3. Nadia Ingabire Manzi
4. Che-Hang Yu
5. Theresa Gibney
6. Yu-Zen Chen
7. Mustafa Basaran
8. Xavier Horton
9. Karsten Siller
10. Ariel Pani
11. Daniel Needleman
12. Daniel J. Dickinson
13. Stefanie Redemann

Reviewed by Review Commons

Context specific ubiquitin modification of ribosomes regulates translation under oxidative stress

1. Shannon E. Dougherty
2. Géssica C. Barros
3. Matthew W. Foster
4. Guoshou Teo
5. Hyungwon Choi
6. Gustavo M. Silva

Reviewed by Review Commons

Temporally resolved single cell transcriptomics in a human model of amniogenesis

1. Nikola Sekulovski
2. Amber E Carleton
3. Anusha A Rengarajan
4. Chien-Wei Lin
5. Lauren L Juga
6. Allison E Whorton
7. Jenna Kropp Schmidt
8. Thaddeus Golos
9. Kenichiro Taniguchi

Reviewed by Review Commons

Compensatory evolution to DNA replication stress is robust to nutrient availability

1. Mariana Natalino
2. Marco Fumasoni

Reviewed by Review Commons

A Dual Role for the PP2A Phosphatase in Hippo Signalling Regulation

1. Aashika Sekar
2. Alberto Rizzo
3. Elodie Sins
4. Alexander D. Fulford
5. Paulo S. Ribeiro

Reviewed by Review Commons

Sex‐dimorphic gene regulation in murine macrophages across niches

1. Cassandra J McGill
2. Olivia S White
3. Ryan J Lu
4. Nirmal K Sampathkumar
5. Bérénice A Benayoun

Reviewed by Review Commons

Dendritic atoh1a+ cells serve as Merkel cell precursors during skin development and regeneration

1. Evan W. Craig
2. Erik C. Black
3. Samantha Z. Fernandes
4. Ahlan S. Ferdous
5. Camille E. A. Goo
6. Sheridan M. Sargent
7. Elgene J. A. Quitevis
8. Avery Angell Swearer
9. Nathaniel G. Yee
10. Jimann Shin
11. Lilianna Solnica-Krezel
12. Jeffrey P. Rasmussen

Reviewed by Review Commons

Mitochondrial dysfunction heightens the integrated stress response to drive ALS pathogenesis

1. Curran Landry
2. James Costanzo
3. Miguel Mitne-Neto
4. Mayana Zatz
5. Ashleigh Schaffer
6. Maria Hatzoglou
7. Alysson Muotri
8. Helen Cristina Miranda

Reviewed by Review Commons

Hypoxia impedes differentiation of cranial neural crest cells into derivatives relevant for craniofacial development

1. Theresa Schmid
2. Gabriele Rodrian
3. Elke Bachmann
4. Alexander Kohler
5. Michael Wegner
6. Lina Gölz
7. Matthias Weider

Reviewed by Review Commons

Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility

1. Shivraj M Yabaji
2. Vadim Zhernovkov
3. Prasanna Babu Araveti
4. Suruchi Lata
5. Oleksii S Rukhlenko
6. Salam Al Abdullatif
7. Arthur Vanvalkenburg
8. Yuriy O Alekseyev
9. Qicheng Ma
10. Gargi Dayama
11. Nelson C Lau
12. W Evan Johnson
13. William R Bishai
14. Nicholas A Crossland
15. Joshua D Campbell
16. Boris N Kholodenko
17. Alexander A Gimelbrant
18. Lester Kobzik
19. Igor Kramnik

• Curated by eLife

  eLife Assessment

  Yabaji et al. reports a fundamental study highlighting the mechanistic connection for susceptibility to TB infection via the sst1 locus, this was shown to involve increased IFN and Myc production causing the down-regulation of anti-oxidant defence genes and chronic lipidation. Ultimately, lipid peroxidation may underlie infectivity and macrophage dysfunction. Overall, the data presented are compelling, supported by a well designed multi-omics approach and the findings will be of broad interest to researchers investigating the molecular mechanisms of TB infection.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Dual-action peptide shuttles rescue Cu-amyloid-β-induced neurotoxicity and relocate Cu intracellularly

1. Michael Okafor
2. David Schmitt
3. Enrico Falcone
4. Stéphane Gasman
5. Laurent Raibaut
6. Christelle Hureau
7. Peter Faller
8. Nicolas Vitale

Reviewed by Review Commons

A conserved chronobiological complex times C. elegans development

1. Rebecca K. Spangler
2. Kathrin Braun
3. Guinevere E. Ashley
4. Marit van der Does
5. Daniel Wruck
6. Andrea Ramos Coronado
7. James Matthew Ragle
8. Vytautas Iesmantavicius
9. Lucas J. Morales Moya
10. Keya Jonnalagadda
11. Carrie L. Partch
12. Helge Großhans
13. Jordan D. Ward

Reviewed by Review Commons

Plasma Membrane Remodelling in GM2 Gangliosidoses Drives Synaptic Dysfunction

1. Alex S. Nicholson
2. David A. Priestman
3. Robin Antrobus
4. James C. Williamson
5. Reuben Bush
6. Henry G. Barrow
7. Emily Smith
8. Kostantin Dobrenis
9. Nicholas A. Bright
10. Frances M. Platt
11. Janet E. Deane

Reviewed by Review Commons

Dual roles of EGO-1 and RRF-1 in regulating germline exo-RNAi efficiency in Caenorhabditis elegans

1. Katsufumi Dejima
2. Keita Yoshida
3. Shohei Mitani

Reviewed by Review Commons