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  1. Interaction hierarchy among Cdv proteins drives recruitment to membrane necks

    This article has 3 authors:
    1. Nicola De Franceschi
    2. Alberto Blanch-Jover
    3. Cees Dekker
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study investigates how the Cdv division proteins of Metallosphaera sedula assemble on and interact with curved membranes in vitro, advancing our understanding of this reduced ESCRT-like machinery. The data provide support for sequential protein recruitment and curvature-dependent enrichment at membrane necks, based on well-controlled reconstitution assays and quantitative analysis. The work establishes a convincing experimental framework for dissecting Cdv-mediated membrane remodeling. The study will be of broad interest to evolutionary and synthetic biologists as well as membrane biophysicists.

    Reviewed by eLife

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