Evaluated articles

A list by eLife

Articles that have been evaluated by eLife.

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  3. SATAY-based chemogenomic screening uncovers antifungal resistance mechanisms and key determinants of ATI-2307 and chitosan sensitivity

    1. Matthew T Karadzas
    2. Agnès H Michel
    3. Andreas Mosbach
    4. George Giannakopoulos
    5. Ruairi McGettigan
    6. Gabriel Scalliet
    7. Benoît Kornmann

    • Curated by eLife

      eLife Assessment

      This important manuscript proposes a new strategy for the identification of new mechanisms of drug resistance based on SAturated Transposon Analysis in Yeast (SATAY), a powerful transposon sequencing method in Saccharomyces cerevisiae. This method allows us to uncover loss- and gain-of-function mutations conferring resistance to 20 different antifungal compounds. The method is convincing, allowing the authors to identify a novel interaction of chitosan with the cell wall mannosylphosphate, and show that the transporter Hol1 concentrates the novel antifungal ATI-2307 within yeast.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  15. Neurons in the medial prefrontal cortex are involved in spatial tuning and signaling upcoming choice independently from hippocampal sharp-wave ripples

    1. Hanna den Bakker
    2. Fabian Kloosterman

    • Curated by eLife

      eLife Assessment

      This useful study reports analyses of Neuropixel recordings in the medial prefrontal cortex and hippocampus of rats in a spatial navigation trial, focusing on classifying prefrontal neurons based on SWR modulation and anatomical location. Reviewers were unconvinced by the presented evidence for the claim that distinct populations of mPFC neurons participate in non-local ensemble representations during SWR and non-SWR periods, and were unconvinced by the presented evidence for a previously unrecognized anatomical distinction between these populations. Further analyses might strengthen the incomplete evidence for some conclusions, and some of the strong claims of the paper should likely be moderated.

    Reviewed by eLife

    8 evaluationsAppears in 1 listLatest version Latest activity

  20. Brain-Cognitive Gaps in relation to Dopamine and Health-related Factors: Insights from AI-Driven Functional Connectome Predictions

    1. Morteza Esmaeili
    2. Erin Bjørkeli
    3. Robin Pedersen
    4. Farshad Falahati
    5. Jarkko Johansson
    6. Kristin Nordin
    7. Nina Karalija
    8. Lars Bäckman
    9. Lars Nyberg
    10. Alireza Salami

    • Curated by eLife

      eLife Assessment

      This multimodal neuroimaging study leverages fMRI, PET, and deep learning to predict memory performance. The authors introduce the brain-cognition gap to link these different imaging modalities to cognition and evaluate their results in two independent cohorts. The results are solid and provide an important contribution to the literature and will be of interest to neuroscientists working at the interface of cognition, neuroimaging.

    Reviewed by eLife

    13 evaluationsAppears in 1 listLatest version Latest activity
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