Evaluated articles

Evolution of multicellularity by collective integration of spatial information

1. Enrico Sandro Colizzi
2. Renske MA Vroomans
3. Roeland MH Merks

Reviewed by eLife

Data from Multimodal Molecular Imaging Detects Early Responses to Immune Checkpoint Blockade

1. Yu Saida
2. Jeffrey R. Brender
3. Kazutoshi Yamamoto
4. James B. Mitchell
5. Murali C. Krishna
6. Shun Kishimoto

Reviewed by eLife

GATA‐1‐dependent histone H3K27 acetylation mediates erythroid cell‐specific chromatin interaction between CTCF sites

1. Yea Woon Kim
2. Yujin Kang
3. Jin Kang
4. AeRi Kim

Reviewed by eLife

Extensive ribosome and RF2 rearrangements during translation termination

1. Egor Svidritskiy
2. Gabriel Demo
3. Anna B Loveland
4. Chen Xu
5. Andrei A Korostelev

Reviewed by eLife

Microtubule reorganization during female meiosis in C. elegans

1. Ina Lantzsch
2. Che-Hang Yu
3. Yu-Zen Chen
4. Vitaly Zimyanin
5. Hossein Yazdkhasti
6. Norbert Lindow
7. Erik Szentgyoergyi
8. Ariel M Pani
9. Steffen Prohaska
10. Martin Srayko
11. Sebastian Fürthauer
12. Stefanie Redemann

Reviewed by eLife

Perceptual gating of a brainstem reflex facilitates speech understanding in human listeners

1. Heivet Hernandez-Perez
2. Jason Mikiel-Hunter
3. David McAlpine
4. Sumitrajit Dhar
5. Sriram Boothalingam
6. Jessica J.M. Monaghan
7. Catherine M. McMahon

Reviewed by eLife

Increased longevity due to sexual activity in mole-rats is associated with transcriptional changes in the HPA stress axis

1. Arne Sahm
2. Matthias Platzer
3. Philipp Koch
4. Yoshiyuki Henning
5. Martin Bens
6. Marco Groth
7. Hynek Burda
8. Sabine Begall
9. Saskia Ting
10. Moritz Goetz
11. Paul Van Daele
12. Magdalena Staniszewska
13. Jasmin Mona Klose
14. Pedro Fragoso Costa
15. Steve Hoffmann
16. Karol Szafranski
17. Philip Dammann

Reviewed by eLife

A MAPK/miR-29 Axis Suppresses Melanoma by Targeting MAFG and MYBL2

1. Olga Vera
2. Ilah Bok
3. Neel Jasani
4. Koji Nakamura
5. Xiaonan Xu
6. Nicol Mecozzi
7. Ariana Angarita
8. Kaizhen Wang
9. Kenneth Y. Tsai
10. Florian A. Karreth

Reviewed by eLife

Integration of multiple imaging platforms to uncover cardiac defects in adult zebrafish

1. Anabela Bensimon-Brito
2. Giulia L. M. Boezio
3. João Cardeira-da-Silva
4. Astrid Wietelmann
5. Christian S. M. Helker
6. Radhan Ramadass
7. Janett Piesker
8. Arno Nauerth
9. Clemens Mueller
10. Didier Y. R. Stainier

Reviewed by eLife

Dot1l interacts with Zc3h10 to activate Ucp1 and other thermogenic genes

1. Danielle Yi
2. Hai P Nguyen
3. Jennie Dinh
4. Jose A Viscarra
5. Ying Xie
6. Frances Lin
7. Madeleine Zhu
8. Jon M Dempersmier
9. Yuhui Wang
10. Hei Sook Sul

Reviewed by eLife

Protective role of neuronal and lymphoid cannabinoid CB2 receptors in neuropathic pain

1. David Cabañero
2. Angela Ramírez-López
3. Eva Drews
4. Anne Schmöle
5. David M Otte
6. Agnieszka Wawrzczak-Bargiela
7. Hector Huerga Encabo
8. Sami Kummer
9. Antonio Ferrer-Montiel
10. Ryszard Przewlocki
11. Andreas Zimmer
12. Rafael Maldonado

Reviewed by eLife

The 20S proteasome activator PA28γ controls the compaction of chromatin

1. Didier Fesquet
2. David Llères
3. Charlotte Grimaud
4. Cristina Viganò
5. Francisca Méchali
6. Séverine Boulon
7. Olivier Coux
8. Catherine Bonne-Andrea
9. Véronique Baldin

Reviewed by eLife

Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response

1. Matthew D Keefe
2. Haille E Soderholm
3. Hung-Yu Shih
4. Tamara J Stevenson
5. Kathryn A Glaittli
6. D Miranda Bowles
7. Erika Scholl
8. Samuel Colby
9. Samer Merchant
10. Edward W Hsu
11. Joshua L Bonkowsky

Reviewed by eLife

Toxoplasma gondii Infection Drives Conversion of NK Cells into ILC1s

1. Eugene Park
2. Swapneel J. Patel
3. Qiuling Wang
4. Prabhakar S. Andhey
5. Konstantin Zaitsev
6. Sofia I. Porter
7. Maxwell L. Hershey
8. Michael D. Bern
9. Beatrice Plougastel-Douglas
10. Patrick L. Collins
11. Marco Colonna
12. Kenneth M. Murphy
13. Eugene M. Oltz
14. Maxim N. Artyomov
15. L. David Sibley
16. Wayne M. Yokoyama

Reviewed by eLife

The peroxisome counteracts oxidative stresses by suppressing catalase import via Pex14 phosphorylation

1. Kanji Okumoto
2. Mahmoud El Shermely
3. Masanao Natsui
4. Hidetaka Kosako
5. Ryuichi Natsuyama
6. Toshihiro Marutani
7. Yukio Fujiki

Reviewed by eLife

The evolution of coloration and opsins in tarantulas

1. Saoirse Foley
2. Vinodkumar Saranathan
3. William H. Piel

Reviewed by eLife

N-terminal domain regulates steroid activation of elephant shark glucocorticoid and mineralocorticoid receptors

1. Yoshinao Katsu
2. Islam M.D. Shariful
3. Xiaozhi Lin
4. Wataru Takagi
5. Hiroshi Urushitani
6. Satomi Kohno
7. Susumu Hyodo
8. Michael E. Baker

Reviewed by eLife

Cortex cis -regulatory switches establish scale colour identity and pattern diversity in Heliconius

1. Luca Livraghi
2. Joseph J. Hanly
3. Steven M. Van Belleghem
4. Gabriela Montejo-Kovacevich
5. Eva S. M. van der Heijden
6. Ling Sheng Loh
7. Anna Ren
8. Ian A. Warren
9. James J. Lewis
10. Carolina Concha
11. Laura H. López
12. Charlotte Wright
13. Jonah M. Walker
14. Jessica Foley
15. Zachary H. Goldberg
16. Henry Arenas-Castro
17. Michael W. Perry
18. Riccardo Papa
19. Arnaud Martin
20. W. Owen McMillan
21. Chris D. Jiggins

• Curated by eLife

  Evaluation Summary:

  This paper shows complex gene regulation for a simple binary switch phenotype. Cis-regulatory elements that control expression from the promoter of the gene cortex are shown to be evolutionary targets for changing cortex-dependent scale types in a discrete region of the Heliconius hindwing. Multiple approaches are used to identify the likely causal genetic variation in the cortex locus that is responsible for the presence/absence of the yellow band. It is an interesting case showing how a gene with a homogeneous expression pattern across the wing (during the pupal stage) can still have "hidden" modular regulatory regions that drive unique functions (albeit not expression) is specific regions of the wing.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

NAIP–NLRC4-deficient mice are susceptible to shigellosis

1. Patrick S Mitchell
2. Justin L Roncaioli
3. Elizabeth A Turcotte
4. Lisa Goers
5. Roberto A Chavez
6. Angus Y Lee
7. Cammie F Lesser
8. Isabella Rauch
9. Russell E Vance

Reviewed by eLife

Multiple Wnts act synergistically to induce Chk1/Grapes expression and mediate G2 arrest in Drosophila tracheoblasts

1. Amrutha Kizhedathu
2. Rose Sebastian Kunnappallil
3. Archit V Bagul
4. Puja Verma
5. Arjun Guha

Reviewed by eLife