Evaluated articles

Metabolic control of cellular immune-competency by odors in Drosophila

1. Sukanya Madhwal
2. Mingyu Shin
3. Ankita Kapoor
4. Manisha Goyal
5. Manish K Joshi
6. Pirzada Mujeeb Ur Rehman
7. Kavan Gor
8. Jiwon Shim
9. Tina Mukherjee

Reviewed by eLife

Coupling between fast and slow oscillator circuits in Cancer borealis is temperature-compensated

1. Daniel Powell
2. Sara A Haddad
3. Srinivas Gorur-Shandilya
4. Eve Marder

Reviewed by eLife

Multi-contrast anatomical subcortical structures parcellation

1. Pierre-Louis Bazin
2. Anneke Alkemade
3. Martijn J Mulder
4. Amanda G Henry
5. Birte U Forstmann

Reviewed by eLife

Single molecule microscopy reveals key physical features of repair foci in living cells

1. Judith Miné-Hattab
2. Mathias Heltberg
3. Marie Villemeur
4. Chloé Guedj
5. Thierry Mora
6. Aleksandra M Walczak
7. Maxime Dahan
8. Angela Taddei

Reviewed by eLife

Substrate Transport and Specificity in a Phospholipid Flippase

1. Yong Wang
2. Joseph A Lyons
3. Milena Timcenko
4. Felix Kümmerer
5. Bert L. de Groot
6. Poul Nissen
7. Vytautas Gapsys
8. Kresten Lindorff-Larsen

Reviewed by eLife

CDK2 activity determines the timing of cell-cycle commitment and sequential DNA replication

1. Sungsoo Kim
2. Alessandra Leong
3. Chellam Nayar
4. Minah Kim
5. Hee Won Yang

Reviewed by eLife

Quantitative live-cell imaging and computational modeling shed new light on endogenous WNT/CTNNB1 signaling dynamics

1. Saskia MA de Man
2. Gooitzen Zwanenburg
3. Tanne van der Wal
4. Mark A Hink
5. Renée van Amerongen

• Curated by eLife

  Evaluation Summary:

  Wnt signaling plays critical roles in cell fate determination in essentially every tissue in all animals, regulates tissue homeostasis in many adult tissues, and is inappropriately activated in many human cancers. It has been the focus of research for decades, and we have an outline of signal transduction. Remarkably, some of the key questions of Wnt signaling remain controversial. Central among these are questions about the nature of the negative regulatory destruction complex, its mechanism of action and how it is turned down by Wnt signaling. Here Saskia and colleagues take a novel and very exciting approach to these questions, combining innovative quantitative live-cell imaging and computational modelling.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans

1. Omar Al Rifai
2. Catherine Julien
3. Julie Lacombe
4. Denis Faubert
5. Erandi Lira-Navarrete
6. Yoshiki Narimatsu
7. Henrik Clausen
8. Mathieu Ferron

Reviewed by eLife

Organization of DNA Replication Origin Firing in Xenopus Egg Extracts: The Role of Intra-S Checkpoint

1. Diletta Ciardo
2. Olivier Haccard
3. Hemalatha Narassimprakash
4. Jean-Michel Arbona
5. Olivier Hyrien
6. Benjamin Audit
7. Kathrin Marheineke
8. Arach Goldar

Reviewed by eLife

Structure of the bacterial ribosome at 2 Å resolution

1. Zoe L Watson
2. Fred R Ward
3. Raphaël Méheust
4. Omer Ad
5. Alanna Schepartz
6. Jillian F Banfield
7. Jamie HD Cate

Reviewed by eLife

Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair

1. Oguz Bolgi
2. Maria Silva‐Garcia
3. Breyan Ross
4. Esther Pilla
5. Vijayalakshmi Kari
6. Markus Killisch
7. Melanie Spitzner
8. Nadine Stark
9. Christof Lenz
10. Konstantin Weiss
11. Laura Donzelli
12. Mark D Gorrell
13. Marian Grade
14. Jan Riemer
15. Henning Urlaub
16. Matthias Dobbelstein
17. Robert Huber
18. Ruth Geiss‐Friedlander

Reviewed by eLife

Comparison of induced neurons reveals slower structural and functional maturation in humans than in apes

1. Maria Schörnig
2. Xiangchun Ju
3. Luise Fast
4. Sebastian Ebert
5. Anne Weigert
6. Sabina Kanton
7. Theresa Schaffer
8. Nael Nadif Kasri
9. Barbara Treutlein
10. Benjamin Marco Peter
11. Wulf Hevers
12. Elena Taverna

Reviewed by eLife

Effects of Early Life Stress on Bone Homeostasis in Mice and Humans

1. Karin Wuertz-Kozak
2. Martin Roszkowski
3. Elena Cambria
4. Andrea Block
5. Gisela A. Kuhn
6. Thea Abele
7. Wolfgang Hitzl
8. David Drießlein
9. Ralph Müller
10. Michael A. Rapp
11. Isabelle M. Mansuy
12. Eva M. J. Peters
13. Pia M. Wippert

Reviewed by eLife

Predicting the retinotopic organization of human visual cortex from anatomy using geometric deep learning

1. Fernanda L. Ribeiro
2. Steffen Bollmann
3. Alexander M. Puckett

Reviewed by eLife

Arrayed CRISPRi and quantitative imaging describe the morphotypic landscape of essential mycobacterial genes

1. Timothy J de Wet
2. Kristy R Winkler
3. Musa Mhlanga
4. Valerie Mizrahi
5. Digby F Warner

Reviewed by eLife

Vascular control of the CO2/H+-dependent drive to breathe

1. Colin M Cleary
2. Thiago S Moreira
3. Ana C Takakura
4. Mark T Nelson
5. Thomas A Longden
6. Daniel K Mulkey

Reviewed by eLife

Anatomical correlates of face patches in macaque inferotemporal cortex

1. Michael J. Arcaro
2. Theodora Mautz
3. Vladimir K. Berezovskii
4. Margaret S. Livingstone

Reviewed by eLife

Landscape of oncoviral genotype and co-infection via human papilloma and hepatitis B viral tumor in situ profiling

1. Adrian Bubie
2. Fabien Zoulim
3. Barbara Testoni
4. Brett Miles
5. Marshall Posner
6. Augusto Villanueva
7. Bojan Losic

Reviewed by eLife

Increasing heart vascularisation after myocardial infarction using brain natriuretic peptide stimulation of endothelial and WT1+ epicardial cells

1. Na Li
2. Stephanie Rignault-Clerc
3. Christelle Bielmann
4. Anne-Charlotte Bon-Mathier
5. Tamara Déglise
6. Alexia Carboni
7. Mégane Ducrest
8. Nathalie Rosenblatt-Velin

Reviewed by eLife

Removing unwanted variation with CytofRUV to integrate multiple CyTOF datasets

1. Marie Trussart
2. Charis E Teh
3. Tania Tan
4. Lawrence Leong
5. Daniel HD Gray
6. Terence P Speed

Reviewed by eLife