Showing page 148 of 366 pages of list content

  1. The information bottleneck as a principle underlying multi-area cortical representations during decision-making

    This article has 10 authors:
    1. Michael Kleinman
    2. Tian Wang
    3. Derek Xiao
    4. Ebrahim Feghhi
    5. Kenji Lee
    6. Nicole Carr
    7. Yuke Li
    8. Nima Hadidi
    9. Chandramouli Chandrasekaran
    10. Jonathan Kao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript reports a useful computational study of information encoding across the monkey prefrontal and pre-motor cortices during decision making. While many of the conclusions are supported with solid analyses, the evidence for the main claim, the role of an information bottleneck across areas, is incomplete. Refocusing the paper as an RNN modeling study would increase its appeal to a systems and computational neuroscience audience.

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    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  2. Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics

    This article has 13 authors:
    1. Timothy J Walker
    2. Eduardo Reyes-Alvarez
    3. Brandy D Hyndman
    4. Michael G Sugiyama
    5. Larissa CB Oliveira
    6. Aisha N Rekab
    7. Mathieu JF Crupi
    8. Rebecca Cabral-Dias
    9. Qianjin Guo
    10. Patricia LM Dahia
    11. Douglas S Richardson
    12. Costin N Antonescu
    13. Lois M Mulligan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable paper provides convincing evidence that loss of the tumor suppressor TMEM127 causes disorganization of plasma membrane lipid domains, alters clathrin assembly, and inhibits endocytosis of a variety of cell surface receptors, leading to increased cell surface levels of signaling proteins including RET and other transmembrane receptor tyrosine kinases. The results are significant for understanding how RET127 loss contributes to pheochromocytoma, although the evidence is indirect owing to the lack of human pheochromocytoma cell lines. The results will be of interest for researchers studying pheochromocytoma and endocytosis mechanisms.

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    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  3. The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults

    This article has 11 authors:
    1. Arya Y Nakhe
    2. Prasanna K Dadi
    3. Jinsun Kim
    4. Matthew T Dickerson
    5. Soma Behera
    6. Jordyn R Dobson
    7. Shristi Shrestha
    8. Jean-Philippe Cartailler
    9. Leesa Sampson
    10. Mark A Magnuson
    11. David A Jacobson
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study characterizes how a point mutation in the TALK-1 potassium channel, encoded by the KCNK16 gene, causes MODY diabetes. The mutation, L114P, causes a gain-of-function to increase K+ currents and inhibit glucose-stimulated insulin secretion. Increased glucagon likely results from paracrine effects in the islets. The data are convincing and the work will be valuable for understanding islet function.

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    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  4. Dual-color optical activation and suppression of neurons with high temporal precision

    This article has 12 authors:
    1. Noëmie Mermet-Joret
    2. Andrea Moreno
    3. Agnieszka Zbela
    4. Milad Nazari
    5. Bárður Eyjólfsson Ellendersen
    6. Raquel Comaposada-Baro
    7. Nathalie Krauth
    8. Anne von Philipsborn
    9. Andreas Toft Sørensen
    10. Joaquin Piriz
    11. John Y Lin
    12. Sadegh Nabavi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study develops useful tools for distinct optogenetic control of neuronal activity by red or blue light. The basic characterization of the activation of a red-shifted channelrhodopsin paired with a blue-light sensitive anion channel engineered to obtain desired inhibitory current kinetics is solid. However, evidence for their practical use under simultaneous multi-color or high frequency stimulation in cells are missing.

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    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  5. A maximum of two readily releasable vesicles per docking site at a cerebellar single active zone synapse

    This article has 3 authors:
    1. Melissa Silva
    2. Van Tran
    3. Alain Marty
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The study used slice physiology and modeling to investigate neurotransmitter release at the cerebellar parallel fiber-to-molecular layer interneuron synapse, revealing that each docking site can accommodate up to two synaptic vesicles simultaneously. The evidence presented is convincing. These important findings validate a two-step docking model and shed light on the mechanisms underlying short-term synaptic plasticity and strategies for achieving synaptic reliability, which plays a critical role in information processing in the brain.

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    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  6. Distinctive whole-brain cell types predict tissue damage patterns in thirteen neurodegenerative conditions

    This article has 6 authors:
    1. Veronika Pak
    2. Quadri Adewale
    3. Danilo Bzdok
    4. Mahsa Dadar
    5. Yashar Zeighami
    6. Yasser Iturria-Medina
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Pak et al. examined the relationship between the most common spatial patterns of neurodegeneration and transcriptional markers of the density of different cell types in the cerebral cortex. This valuable study uses innovative methods to provide convincing evidence that patterns of grey matter loss in various forms of dementia are correlated with the anatomical distribution of non-neuronal cell types.

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    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  7. Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings

    This article has 27 authors:
    1. Shek Man Chim
    2. Kristen Howell
    3. John Dronzek
    4. Weizhen Wu
    5. Cristopher Van Hout
    6. Manuel AR Ferreira
    7. Bin Ye
    8. Alexander Li
    9. Susannah Brydges
    10. Vinayagam Arunachalam
    11. Anthony Marcketta
    12. Adam E Locke
    13. Jonas Bovijn
    14. Niek Verweij
    15. Tanima De
    16. Luca Lotta
    17. Lyndon Mitnaul
    18. Michelle LeBlanc
    19. Regeneron Genetics Center
    20. David J Carey
    21. Olle Melander
    22. Alan Shuldiner
    23. Katia Karalis
    24. Aris N Economides
    25. Harikiran Nistala
    26. DiscovEHR collaboration
    27. Regeneron Genetics Center
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This fundamental study substantially advances our understanding of the role of zinc in metabolism, specifically a newly established clinical link between mutations in the zinc transporter SLC39A5, elevated serum zinc levels, and a reduction in the risk of Type 2 Diabetes. The provided evidence is solid with state-of-the-art genetic analysis of large human cohorts followed by a comprehensive analysis of a mouse SLC39A5 knockout mutant, establishing that SLC39A5 plays a role in hepatic lipid handling through AMPK signaling, although the limited analysis of a pancreatic phenotype that has previously been described constitutes a weakness. This study will be of relevance to researchers interested in metabolism, fatty liver disease, and the biology of trace elements.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  8. An observational treatment study of metacognition in anxious-depression

    This article has 11 authors:
    1. Celine Ann Fox
    2. Chi Tak Lee
    3. Anna Kathleen Hanlon
    4. Tricia XF Seow
    5. Kevin Lynch
    6. Siobhán Harty
    7. Derek Richards
    8. Jorge Palacios
    9. Veronica O'Keane
    10. Klaas Enno Stephan
    11. Claire M Gillan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study advances our knowledge of the effects of anxiety/depression treatment on metacognition, demonstrating that treatment increases metacognitive confidence alongside improving symptoms. The authors provide convincing evidence for the state-dependency of metacognitive confidence, based on a large longitudinal treatment dataset. However, it is unclear to what extent this effect is truly specific to treatment, as changes in metacognitive confidence in the group receiving online therapy were not statistically different from those in the control group.

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    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  9. Neural correlates of perceptual similarity masking in primate V1

    This article has 4 authors:
    1. Spencer Chin-Yu Chen
    2. Yuzhi Chen
    3. Wilson S Geisler
    4. Eyal Seidemann
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study used Voltage Sensitive Dye Imaging (VSDI) to measure neural activity in the primary visual cortex of monkeys trained to detect an oriented grating target that was presented either alone or against an oriented mask. The authors show convincingly that the initial effect of the mask ran counter to the behavioral effects of the mask, a pattern that reversed in the latter phase of the response. They interpret these results in terms of influences from the receptive field center, and although an alternative view that emphasizes the role of the receptive field surround also seems reasonable, this study stands as an interesting contribution to our understanding of mechanisms of visual perception.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  10. Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer’s disease

    This article has 10 authors:
    1. Elissavet Chartampila
    2. Karim S Elayouby
    3. Paige Leary
    4. John J LaFrancois
    5. David Alcantara-Gonzalez
    6. Swati Jain
    7. Kasey Gerencer
    8. Justin J Botterill
    9. Stephen D Ginsberg
    10. Helen E Scharfman
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this fundamental work, the authors demonstrated that maternal choline supplementation improved spatial memory, reduced hyperexcitability, and restored NeuN expression in a familial Alzheimer's disease mouse model. Interestingly, choline deficiency increased mortality, while paradoxically reduced hyperexcitability. Through behavioral, electrophysiological, and histological measures, the authors present convincing evidence supporting the significant role of maternal choline supplementation in protecting hippocampal functions vulnerable to Alzheimer's disease.

    Reviewed by eLife

    This article has 12 evaluationsAppears in 1 listLatest version Latest activity
  11. Measures of genetic diversification in somatic tissues at bulk and single-cell resolution

    This article has 4 authors:
    1. Marius E Moeller
    2. Nathaniel V Mon Père
    3. Benjamin Werner
    4. Weini Huang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this paper, the authors introduce fundamental work on mathematical methods for inferring evolutionary parameters of interest from RNA data in healthy tissue and during hematopoiesis. By combining single cell and bulk sequencing analyses, the authors use a stochastic process to inform different aspects of genetic heterogeneity; the strength of evidence in support of the authors' claim is exceptional. The work will be of broad interest to cell biologists and theoretical biologists.

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    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  12. Glutamatergic supramammillary nucleus neurons respond to threatening stressors and promote active coping

    This article has 11 authors:
    1. Abraham Escobedo
    2. Salli-Ann Holloway
    3. Megan Votoupal
    4. Aaron L Cone
    5. Hannah Skelton
    6. Alex A Legaria
    7. Imeh Ndiokho
    8. Tasheia Floyd
    9. Alexxai V Kravitz
    10. Michael R Bruchas
    11. Aaron J Norris
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important manuscript investigates the role of a subpopulation of glutamatergic neurons in the suprammamillary nucleus that projects to the pre-optic hypothalamus area in active coping but not locomotor activity. They provide solid evidence from experiments using fibre photometry or photostimulation during threatening tasks that these neurons allow animals to produce flexible behaviours in response to stress. This work will be of interest to behavioural and systems neuroscientists.

    Reviewed by eLife

    This article has 11 evaluationsAppears in 1 listLatest version Latest activity
  13. Get the gist of the story: Neural map of topic keywords in multi-speaker environment

    This article has 2 authors:
    1. Hyojin Park
    2. Joachim Gross
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study advances our understanding of how listeners understand speech when there are multiple talkers by showing that the content of the speech affects acoustic processing. The evidence is generally solid, although additional details on the methods to allow replication would strengthen the study. The work will be of use to researchers interested in the neuroscience of speech and language processing.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  14. Towards a Neurometric-based Construct Validity of Trust

    This article has 5 authors:
    1. Pin-Hao A. Chen
    2. Dominic Fareri
    3. Berna Güroğlu
    4. Mauricio R. Delgado
    5. Luke J. Chang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study identifies a spatial pattern of neural activity that corresponds to trust in an investment game. It provides a compelling assessment of the validity of this pattern by assessing its expression, or lack thereof, in a variety of datasets. This work, and the "neurometrics" approach it proposes, will be of broad interest to psychology researchers more generally.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  15. Truncated radial glia as a common precursor in the late corticogenesis of gyrencephalic mammals

    This article has 11 authors:
    1. Merve Bilgic
    2. Quan Wu
    3. Taeko Suetsugu
    4. Atsunori Shitamukai
    5. Yuji Tsunekawa
    6. Tomomi Shimogori
    7. Mitsutaka Kadota
    8. Osamu Nishimura
    9. Shigehiro Kuraku
    10. Hiroshi Kiyonari
    11. Fumio Matsuzaki
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is an important study that improves gene models for the ferret genome and identifies neural progenitors that are comparable to those found in developing human brains. The data are convincing and clearly presented. Of particular interest to the field, the work identifies enriched expression of FOXJ1 in late truncated radial glia, strongly indicating that towards the end of neurogenesis, these cells likely give rise to ependymal cells. The work is of interest to anyone studying the development of the nervous system, especially colleagues studying the evolution of development.

    Reviewed by eLife, Review Commons

    This article has 11 evaluationsAppears in 2 listsLatest version Latest activity
  16. An in silico testbed for fast and accurate MR labeling of orthopedic implants

    This article has 10 authors:
    1. Gregory M Noetscher
    2. Peter J Serano
    3. Marc Horner
    4. Alexander Prokop
    5. Jonathan Hanson
    6. Kyoko Fujimoto
    7. James Brown
    8. Ara Nazarian
    9. Jerome Ackerman
    10. Sergey N Makaroff
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript will provide a valuable method to evaluate the safety of MR in patients with orthopaedic implants, which is required in clinics. A strength of the work is that the in-silicon testbed is solid, based on the widely available human project, and validated. In addition, the toolbox will be open for clinical practice.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  17. Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model

    This article has 3 authors:
    1. Yunlu Xue
    2. Yimin Zhou
    3. Constance L Cepko
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This fundamental study advances our understanding of the cell specific treatment of cone photoreceptor degeneration by Txnip. The evidence supporting the conclusions is compelling with rigorous genetic manipulation of Txnip mutations. The work will be of broad interest to vision researchers, cell biologists and biochemists.

    Reviewed by eLife

    This article has 13 evaluationsAppears in 1 listLatest version Latest activity
  18. BRAIDing receptors for cell-specific targeting

    This article has 12 authors:
    1. Hui Chen
    2. Sung-Jin Lee
    3. Ryan Li
    4. Asmiti Sura
    5. Nicholas Suen
    6. Archana Dilip
    7. Yan Pomogov
    8. Meghah Vuppalapaty
    9. Timothy T Suen
    10. Chenggang Lu
    11. Yorick Post
    12. Yang Li
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study presents a new way to selectively activate a cell signaling pathway in a specific cell type by designer ligands that link signaling co-receptors to a marker specific to the target cells. Convincing experimental results demonstrate that the agonist molecules activate Wnt signaling in target cells expressing the marker as intended. More broadly, this concept could be used to induce Wnt signaling or another pathway initiated by co-receptor association in a cell type-specific manner. In vitro results in this study could be further strengthened by assessing the biological consequences of Wnt activation in target cells.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  19. Baited reconstruction with 2D template matching for high-resolution structure determination in vitro and in vivo without template bias

    This article has 3 authors:
    1. Bronwyn A Lucas
    2. Benjamin A Himes
    3. Nikolaus Grigorieff
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is an important demonstration of how the false-positive rate of high-resolution 2D template matching to find particles of a given target structure in 2D cryo-EM images (2DTM) relates to overfitting the data towards the template. The authors present new methods to measure the amount of model bias that gets introduced in high-resolution features of such maps, with compelling evidence that high-resolution features that are not present in the template can still be reconstructed in 3D from images obtained by 2DTM.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  20. Homeostatic Synaptic Plasticity of Miniature Excitatory Postsynaptic Currents in Mouse Cortical Cultures Requires Neuronal Rab3A

    This article has 3 authors:
    1. Andrew G. Koesters
    2. Mark M. Rich
    3. Kathrin L. Engisch
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents valuable findings on the role of the small GTPase Rab3A in homeostatic plasticity. While the study demonstrates that Rab3A is required for homeostatic scaling, the evidence supporting the model put forward by the authors is incomplete. The work will be of interest to researchers in the field of synaptic transmission and plasticity.

    Reviewed by eLife

    This article has 15 evaluationsAppears in 1 listLatest version Latest activity