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  1. Innate lymphoid cells and COVID-19 severity in SARS-CoV-2 infection

    This article has 18 authors:
    1. Noah J Silverstein
    2. Yetao Wang
    3. Zachary Manickas-Hill
    4. Claudia Carbone
    5. Ann Dauphin
    6. Brittany P Boribong
    7. Maggie Loiselle
    8. Jameson Davis
    9. Maureen M Leonard
    10. Leticia Kuri-Cervantes
    11. MGH COVID-19 Collection & Processing Team
    12. Nuala J Meyer
    13. Michael R Betts
    14. Jonathan Z Li
    15. Bruce D Walker
    16. Xu G Yu
    17. Lael M Yonker
    18. Jeremy Luban
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      The authors present an interesting approach of COVID-19 pathogenesis with emphasis on the role of innate lymphoid cells as a major correlate of the severity of COVID-19 and of the levels of inflammatory markers. The main strength of the manuscript is the novelty of approach, and the fact that the authors are the first to find this potentially interesting correlation, which brings up a number of both translational and mechanistic possibilities of significance. The limitation, of course, is the difficulty in showing a cause-and-effect relationship between the reduction in of innate lymphoid cells and the severity of COVID-19 inflammation.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

    Reviewed by eLife, ScreenIT

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity
  2. Risk Factors of COVID-19 Patients

    This article has 2 authors:
    1. Ouail Ouchetto
    2. Asmaa Drissi Bourhanbour

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  3. Ct threshold values, a proxy for viral load in community SARS-CoV-2 cases, demonstrate wide variation across populations and over time

    This article has 19 authors:
    1. A Sarah Walker
    2. Emma Pritchard
    3. Thomas House
    4. Julie V Robotham
    5. Paul J Birrell
    6. Iain Bell
    7. John I Bell
    8. John N Newton
    9. Jeremy Farrar
    10. Ian Diamond
    11. Ruth Studley
    12. Jodie Hay
    13. Karina-Doris Vihta
    14. Timothy EA Peto
    15. Nicole Stoesser
    16. Philippa C Matthews
    17. David W Eyre
    18. Koen B Pouwels
    19. COVID-19 Infection Survey team
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      The authors present a systematic and complete study of Ct (cycle threshold) values in RT-PCR tests and gene-specific positivity for the UK ONS infection survey. There are very few datasets like this for any viral pathogen, regardless of pandemics. The patterns are fascinating and thought-provoking.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife, ScreenIT

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  4. Estimation of the severeness rate, death rate, household attack rate and the total number of COVID-19 cases based on 16 115 Polish surveillance records

    This article has 17 authors:
    1. The MOCOS International Research Group
    2. Barbara Adamik
    3. Marek Bawiec
    4. Viktor Bezborodov
    5. Przemyslaw Biecek
    6. Wolfgang Bock
    7. Marcin Bodych
    8. Jan Pablo Burgard
    9. Tyll Krueger
    10. Agata Migalska
    11. MOCOS
    12. Tomasz Ożański
    13. Barbara Pabjan
    14. Magdalena Rosińska
    15. Malgorzata Sadkowska-Todys
    16. Piotr Sobczyk
    17. Ewa Szczurek

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity