Evaluated articles

A list by ScreenIT

Articles that have been evaluated by ScreenIT.

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  7. SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets

    1. Palur V Raghuvamsi
    2. Nikhil K Tulsian
    3. Firdaus Samsudin
    4. Xinlei Qian
    5. Kiren Purushotorman
    6. Gu Yue
    7. Mary M Kozma
    8. Wong Y Hwa
    9. Julien Lescar
    10. Peter J Bond
    11. Paul A MacAry
    12. Ganesh S Anand

    • Curated by eLife

      Summary: This is a timely and interesting exploration of the interaction between the Spike protein of SARS-CoV-2, the virus responsible for the COVID-19 pandemic, and the ACE2 receptor using hydrogen deuterium exchange mass spectrometry and molecular dynamics simulations. The Spike protein consists of two sub-domains S1 and S2 with the S1 needing to be cleaved-off so the S2 can become the fusion protein responsible for getting the SARS-CoV-2 into the cell. Structures are available but they do not shed light on how the protease furin can access the cleavage site between S1 and S2 in order to begin the process of fusion. The results suggest that the Spike-ACE2 interaction induces extremely long-range allosteric effects on the Spike protein that could trigger proteolysis of the Spike protein. Specifically, when ACE2 binds to the Spike protein, a conformational change occurs near the S1/S2 cleavage site, exposing it and likely making it more susceptible to furin cleavage. The binding also dampens exchange in the stalk region of the Spike protein. The authors refer to these regions as "dynamic hotspots in the pre-fusion state". The results of this work have implications for the development of small molecule inhibitors.

      In general, the work is timely, and the results will be of interest to many in the field. The major conclusions of the work are generally supported by the results.

    Reviewed by eLife, ScreenIT

    5 evaluationsAppears in 2 listsLatest version Latest activity

  9. Forecasting PPE Consumption during a Pandemic: The Case of Covid-19

    1. Kristian Lum
    2. James Johndrow
    3. April Cardone
    4. Barry Fuchs
    5. Cody E. Cotner
    6. Olivia Jew
    7. Ravi B. Parikh
    8. Michael Draugelis
    9. ThaiBinh Luong
    10. Asaf Hanish
    11. Gary E. Weissman
    12. Christian Terwiesch
    13. Kevin G. Volpp

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  20. SARS-CoV-2 Infection and Stroke: Coincident or Causal?

    1. Melanie Walker
    2. Christopher C. Young
    3. Malveeka Sharma
    4. Michael R. Levitt
    5. David L. Tirschwell
    6. the WWAMI Stroke Investigators

    Reviewed by ScreenIT

    3 evaluationsAppears in 1 listLatest version Latest activity
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