Evaluated articles

Targeting of the NLRP3 Inflammasome for early COVID-19

1. Carlo Marchetti
2. Kara Mould
3. Isak W. Tengesdal
4. William J Janssen
5. Charles A. Dinarello

Reviewed by ScreenIT

N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2

1. Fang Tian
2. Bei Tong
3. Liang Sun
4. Shengchao Shi
5. Bin Zheng
6. Zibin Wang
7. Xianchi Dong
8. Peng Zheng

• Curated by eLife

  Evaluation Summary:

  Tian et al. used a battery of biophysical techniques to compare wild-type SARS-CoV-2 with two variants (B.1.1.7 and B.1.351). The authors obtained evidence consistent with the receptor-binding domain (RBD) of the variants exhibiting higher affinity ACE2, providing a possible explanation for their higher transmission. However, the effects are modest, and further work will be needed to confirm that this difference explains the increased transmission of the variants. Despite the need for follow-up studies, the paper is among the first to show definitively that the N501Y mutation confers enhanced binding to ACE2.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife, ScreenIT

Antibody and T cell responses to a single dose of the AZD1222/Covishield vaccine in previously SARS-CoV-2 infected and naïve health care workers in Sri Lanka

1. Chandima Jeewandara
2. Achala Kamaladasa
3. Pradeep Darshana Pushpakumara
4. Deshni Jayathilaka
5. Inoka Sepali Abayrathna
6. Saubhagya Danasekara
7. Dinuka Guruge
8. Thushali Ranasinghe
9. Shashika Dayarathne
10. Thilagaraj Pathmanathan
11. Gayasha Somathilaka
12. Deshan Madhusanka
13. Shyrar Tanussiya
14. Tibutius TPJ
15. Heshan Kuruppu
16. Ayesha Wijesinghe
17. Nimasha Thashmi
18. Dushantha Milroy
19. Achini Nandasena
20. Nilanka Sanjeewani
21. Ruwan Wijayamuni
22. Sudath Samaraweera
23. Lisa Schimanski
24. T.K. Tan
25. Tao Dong
26. Graham S. Ogg
27. Alain Townsend
28. Gathsaurie Neelika Malavige

Reviewed by ScreenIT

Analysis of the Number of Tests, the Positivity Rate, and Their Dependency Structure during COVID-19 Pandemic

1. Babak Jamshidi
2. Hakim Bekrizadeh
3. Shahriar Jamshidi Zargaran
4. Mansour Rezaei

Reviewed by ScreenIT

A spike-ferritin nanoparticle vaccine induces robust innate immune activity and drives polyfunctional SARS-CoV-2-specific T cells

1. Joshua M. Carmen
2. Shikha Shrivastava
3. Zhongyan Lu
4. Alexander Anderson
5. Elaine B. Morrison
6. Rajeshwer S. Sankhala
7. Wei-Hung Chen
8. William C. Chang
9. Jessica S. Bolton
10. Gary R. Matyas
11. Nelson L. Michael
12. M. Gordon Joyce
13. Kayvon Modjarrad
14. Jeffrey R. Currier
15. Elke Bergmann-Leitner
16. Allison M.W. Malloy
17. Mangala Rao

Reviewed by ScreenIT

More than a year after the onset of the CoVid-19 pandemic in the UK: lessons learned from a minimalistic model capturing essential features including social awareness and policy making

1. Miguel A. Durán-Olivencia
2. Serafim Kalliadasis

Reviewed by ScreenIT

Interactions of SARS-CoV-2 infection with chronic obesity inflammation: a complex network phenomenon

1. Giovani Marino Favero
2. Luis Paulo Gomes Mascarenhas
3. Meirielly Furmann
4. Juliana Berton
5. Pedro Jeferson Miranda

Reviewed by ScreenIT

Increased transmissibility of the alpha SARS-CoV-2 variant: evidence from contact tracing data in Oslo, January to February 2021

1. Jonas Christoffer Lindstrøm
2. Solveig Engebretsen
3. Anja Bråthen Kristoffersen
4. Gunnar Øyvind Isaksson Rø
5. Alfonso Diz-Lois Palomares
6. Kenth Engø-Monsen
7. Elisabeth Henie Madslien
8. Frode Forland
9. Karin Maria Nygård
10. Frode Hagen
11. Gunnar Gantzel
12. Ottar Wiklund
13. Arnoldo Frigessi
14. Birgitte Freiesleben de Blasio

Reviewed by NCRC, ScreenIT

In vitro rapid inactivation of SARS-CoV-2 by visible light photocatalysis using boron-doped bismuth oxybromide

1. Li Ling
2. Tea Carletti
3. Zihang Cheng
4. Ruixuan Wang
5. Yanxiao Ren
6. Paul Westerhoff
7. Chii Shang
8. Alessandro Marcello
9. Shuyu Chen

Reviewed by ScreenIT

Forecast of the covid19 epidemic in France

1. Loïc Pottier

Reviewed by ScreenIT

Neutralization heterogeneity of United Kingdom and South-African SARS-CoV-2 variants in BNT162b2-vaccinated or convalescent COVID-19 healthcare workers

1. Stéphane Marot
2. Isabelle Malet
3. Aude Jary
4. Valentin Leducq
5. Basma Abdi
6. Elisa Teyssou
7. Cathia Soulie
8. Marc Wirden
9. Christophe Rodriguez
10. Slim Fourati
11. Jean-Michel Pawlotsky
12. David Boutolleau
13. Sonia Burrel
14. Vincent Calvez
15. Anne-Geneviève Marcelin

Reviewed by ScreenIT

Zoonotic spillover of SARS-CoV-2: mink-adapted virus in humans

1. Lukasz Rabalski
2. Maciej Kosinski
3. Natalia Mazur-Panasiuk
4. Boguslaw Szewczyk
5. Krystyna Bienkowska-Szewczyk
6. Ravi Kant
7. Tarja Sironen
8. Krysztof Pyrć
9. Maciej Grzybek

Reviewed by ScreenIT

Antiplatelet drugs block platelet activation by VITT patient serum

1. Christopher W. Smith
2. Samantha J. Montague
3. Caroline Kardeby
4. Ying Di
5. Gillian C. Lowe
6. William A. Lester
7. Steve P. Watson
8. Phillip L. R. Nicolson

Reviewed by ScreenIT

Evidence for adaptive evolution in the receptor-binding domain of seasonal coronaviruses OC43 and 229E

1. Kathryn E. Kistler
2. Trevor Bedford

Reviewed by ScreenIT

Targeted Hybridization Capture of SARS-CoV-2 and Metagenomics Enables Genetic Variant Discovery and Nasal Microbiome Insights

1. Dorottya Nagy-Szakal
2. Mara Couto-Rodriguez
3. Heather L. Wells
4. Joseph E. Barrows
5. Marilyne Debieu
6. Kristin Butcher
7. Siyuan Chen
8. Agnes Berki
9. Courteny Hager
10. Robert J. Boorstein
11. Mariah K. Taylor
12. Colleen B. Jonsson
13. Christopher E. Mason
14. Niamh B. O’Hara

Reviewed by ScreenIT

Behavioural nudges increase COVID-19 vaccinations

1. Hengchen Dai
2. Silvia Saccardo
3. Maria A. Han
4. Lily Roh
5. Naveen Raja
6. Sitaram Vangala
7. Hardikkumar Modi
8. Shital Pandya
9. Michael Sloyan
10. Daniel M. Croymans

Reviewed by ScreenIT

The SARS-CoV-2 mRNA-1273 vaccine elicits more RBD-focused neutralization, but with broader antibody binding within the RBD

1. Allison J. Greaney
2. Andrea N. Loes
3. Lauren E. Gentles
4. Katharine H.D. Crawford
5. Tyler N. Starr
6. Keara D. Malone
7. Helen Y. Chu
8. Jesse D. Bloom

Reviewed by ScreenIT

Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies

1. Allison J. Greaney
2. Andrea N. Loes
3. Katharine H.D. Crawford
4. Tyler N. Starr
5. Keara D. Malone
6. Helen Y. Chu
7. Jesse D. Bloom

Reviewed by ScreenIT

Knowledge and Awareness of coronavirus disease 2019 (COVID-19) among Chinese dental students——a comparison study

1. Chengdan Deng
2. Huangshui Ma
3. Yuke Shou
4. Yuxuan Zhao
5. Yang Li
6. Bing Shi

Reviewed by ScreenIT

Acriflavine, a clinically aproved drug, inhibits SARS-CoV-2 and other betacoronaviruses

1. Valeria Napolitano
2. Agnieszka Dabrowska
3. Kenji Schorpp
4. André Mourão
5. Emilia Barreto-Duran
6. Malgorzata Benedyk
7. Pawel Botwina
8. Stefanie Brandner
9. Mark Bostock
10. Yuliya Chykunova
11. Anna Czarna
12. Grzegorz Dubin
13. Tony Fröhlich
14. Michael Hoelscher
15. Malwina Jedrysik
16. Alex Matsuda
17. Katarzyna Owczarek
18. Magdalena Pachota
19. Oliver Plettenburg
20. Jan Potempa
21. Ina Rothenaigner
22. Florian Schlauderer
23. Artur Szczepanski
24. Kristin Greve-Isdahl Mohn
25. Bjorn Blomberg
26. Michael Sattler
27. Kamyar Hadian
28. Grzegorz Maria Popowicz
29. Krzysztof Pyrc

Reviewed by ScreenIT