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  1. Scent dog identification of SARS-CoV-2 infections, similar across different body fluids

    This article has 22 authors:
    1. Paula Jendrny
    2. Friederike Twele
    3. Sebastian Meller
    4. Claudia Schulz
    5. Maren von Köckritz-Blickwede
    6. Ab Osterhaus
    7. Hans Ebbers
    8. Janek Ebbers
    9. Veronika Pilchová
    10. Isabell Pink
    11. Tobias Welte
    12. Michael Peter Manns
    13. Anahita Fathi
    14. Marylyn Martina Addo
    15. Christiane Ernst
    16. Wencke Schäfer
    17. Michael Engels
    18. Anja Petrov
    19. Katharina Marquart
    20. Ulrich Schotte
    21. Esther Schalke
    22. Holger Andreas Volk

    Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  2. Day-by-day symptoms following positive and negative PCR tests for SARS-CoV-2 in non-hospitalized healthcare workers: A 90-day follow-up study

    This article has 20 authors:
    1. Kent J. Nielsen
    2. Jesper Medom Vestergaard
    3. Vivi Schlünssen
    4. Jens Peter Bonde
    5. Kathrine Agergård Kaspersen
    6. Karin Biering
    7. Ole Carstensen
    8. Thomas Greve
    9. Karoline Kærgaard Hansen
    10. Annett Dalbøge
    11. Esben Meulengracht Flachs
    12. Sanne Jespersen
    13. Mette Lausten Hansen
    14. Susan Mikkelsen
    15. Marianne Kragh Thomsen
    16. Jacob Dvinge Redder
    17. Else Toft Würtz
    18. Lars Østergaard
    19. Christian Erikstrup
    20. Henrik Albert Kolstad

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  3. Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19

    This article has 46 authors:
    1. Monique G.P. van der Wijst
    2. Sara E. Vazquez
    3. George C. Hartoularos
    4. Paul Bastard
    5. Tianna Grant
    6. Raymund Bueno
    7. David S. Lee
    8. John R. Greenland
    9. Yang Sun
    10. Richard Perez
    11. Anton Ogorodnikov
    12. Alyssa Ward
    13. Sabrina A. Mann
    14. Kara L. Lynch
    15. Cassandra Yun
    16. Diane V. Havlir
    17. Gabriel Chamie
    18. Carina Marquez
    19. Bryan Greenhouse
    20. Michail S. Lionakis
    21. Philip J. Norris
    22. Larry J. Dumont
    23. Kathleen Kelly
    24. Peng Zhang
    25. Qian Zhang
    26. Adrian Gervais
    27. Tom Le Voyer
    28. Alexander Whatley
    29. Yichen Si
    30. Ashley Byrne
    31. Alexis J. Combes
    32. Arjun Arkal Rao
    33. Yun S. Song
    34. UCSF COMET consortium
    35. Gabriela K. Fragiadakis
    36. Kirsten Kangelaris
    37. Carolyn S. Calfee
    38. David J. Erle
    39. Carolyn Hendrickson
    40. Matthew F. Krummel
    41. Prescott G. Woodruff
    42. Charles R. Langelier
    43. Jean-Laurent Casanova
    44. Joseph L. Derisi
    45. Mark S. Anderson
    46. Chun Jimmie Ye

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  4. Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality

    This article has 20 authors:
    1. Mohamed A Badawy
    2. Basma A Yasseen
    3. Riem M El-Messiery
    4. Engy A Abdel-Rahman
    5. Aya A Elkhodiry
    6. Azza G Kamel
    7. Hajar El-sayed
    8. Asmaa M Shedra
    9. Rehab Hamdy
    10. Mona Zidan
    11. Diaa Al-Raawi
    12. Mahmoud Hammad
    13. Nahla Elsharkawy
    14. Mohamed El Ansary
    15. Ahmed Al-Halfawy
    16. Alaa Elhadad
    17. Ashraf Hatem
    18. Sherif Abouelnaga
    19. Laura L Dugan
    20. Sameh Saad Ali
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      Severe COVID-19 is characterised by a high neutrophil to lymphocyte ratio and an underlying state of oxidative stress in blood has also been hypothesized. In the study presented here for the first time provide evidence that hydrogen peroxide generated by the neutrophil specific enzyme myeloperoxidase is not only accumulated in plasma but also perpetrates structural damage to the strong and weak lipid binding sites on albumin, a key antioxidant in blood plasma, using SLFAs and EPR spectroscopy. This study is timely and relevant in deciding treatment of severe COVID-19 patients with human serum albumin and possibly supplementation of FDA approved antioxidants like glutathione. The main strengths of the manuscript are the novelty. The main weak point is the need to study more patients.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife, ScreenIT

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity