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  1. Enhancing Bone Regeneration and Osseointegration using rhPTH(1-34) and Dimeric R25CPTH(1-34) in an Osteoporotic Beagle Model

    This article has 4 authors:
    1. Jeong-Oh Shin
    2. Jong-Bin Lee
    3. Sihoon Lee
    4. Jin-Woo Kim
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This work by Shin et al. demonstrated that a different form of PTH (R25C PTH) generated a comparable anabolic signal to rhPTH 1-34 using a large animal model. This valuable finding may have therapeutic potential in promoting bone formation or the healing process, and the methods seem solid.

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    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  2. Population clustering of structural brain aging and its association with brain development

    This article has 31 authors:
    1. Haojing Duan
    2. Runye Shi
    3. Jujiao Kang
    4. Tobias Banaschewski
    5. Arun L. W. Bokde
    6. Christian B√ľchel
    7. Sylvane Desrivières
    8. Herta Flor
    9. Antoine Grigis
    10. Hugh Garavan
    11. Penny A. Gowland
    12. Andreas Heinz
    13. R√ľdiger Br√ľhl
    14. Jean-Luc Martinot
    15. Marie-Laure Paillère Martinot
    16. Eric Artiges
    17. Frauke Nees
    18. Dimitri Papadopoulos Orfanos
    19. Tom√°Ň° Paus
    20. Luise Poustka
    21. Sarah Hohmann
    22. Nathalie Holz
    23. Juliane H. Fröhner
    24. Michael N. Smolka
    25. Nilakshi Vaidya
    26. Henrik Walter
    27. Robert Whelan
    28. Gunter Schumann
    29. Xiaolei Lin
    30. Jianfeng Feng
    31. IMAGEN consortium
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study divided structural brain aging into two groups, revealing that one group is more vulnerable to aging and brain-related diseases compared to the other group. This study is valuable as such subtyping could be utilized in predicting and diagnosing cognitive decline and neurodegenerative brain disorders in the future. However, the authors' claims remain incomplete, as there appears to be a lack of connection between this and the authors' claims.

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    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  3. Quantity of SARS-CoV-2 RNA copies exhaled per minute during natural breathing over the course of COVID-19 infection

    This article has 21 authors:
    1. Gregory Lane
    2. Guangyu Zhou
    3. Judd F. Hultquist
    4. Lacy M. Simons
    5. Ramon Lorenzo- Redondo
    6. Egon A. Ozer
    7. Danielle M. McCarthy
    8. Michael G. Ison
    9. Chad J. Achenbach
    10. Xinkun Wang
    11. Ching Man Wai
    12. Eugene Wyatt
    13. Alan Aalsburg
    14. Qiaohan Yang
    15. Torben Noto
    16. Arghavan Alisoltani
    17. Daniel Ysselstein
    18. Rajeshwar Awatramani
    19. Robert Murphy
    20. Grant Theron
    21. Christina Zelano
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable manuscript by Lane introduces an exciting way to measure SARS-CoV-2 aerosolized shedding using a disposable exhaled breath condensate collection device (EBCD). The paper draws the conclusion that the contagious shedding of the virus via the aerosol route persists at a high level until 8 days after symptoms. While the methodology is potentially of high importance and the paper is clearly written, the conclusions are incomplete and only partially supported by the data.

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    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  4. Novel risk loci for COVID-19 hospitalization among admixed American populations

    This article has 122 authors:
    1. Silvia Diz-de Almeida
    2. Raquel Cruz
    3. Andre D. Luchessi
    4. José M. Lorenzo-Salazar
    5. Miguel López de Heredia
    6. Inés Quintela
    7. Rafaela Gonz√°lez-Montelongo
    8. Vivian N. Silbiger
    9. Marta Sevilla Porras
    10. Jair Antonio Tenorio Casta√Īo
    11. Julian Nevado
    12. Jose María Aguado
    13. Carlos Aguilar
    14. Sergio Aguilera-Albesa
    15. Virginia Almadana
    16. Berta Almoguera
    17. Nuria Alvarez
    18. √Ālvaro Andreu-Bernabeu
    19. Eunate Arana-Arri
    20. Celso Arango
    21. María J. Arranz
    22. Maria-Jesus Artiga
    23. Ra√ļl C. Baptista-Rosas
    24. María Barreda- Sánchez
    25. Moncef Belhassen-Garcia
    26. Joao F. Bezerra
    27. Marcos A.C. Bezerra
    28. Lucía Boix-Palop
    29. María Brion
    30. Ramón Brugada
    31. Matilde Bustos
    32. Enrique J. Calderón
    33. Cristina Carbonell
    34. Luis Castano
    35. Jose E. Castelao
    36. Rosa Conde- Vicente
    37. M. Lourdes Cordero-Lorenzana
    38. Jose L. Cortes-Sanchez
    39. Marta Corton
    40. M. Teresa Darnaude
    41. Alba De Martino-Rodríguez
    42. Victor del Campo-Pérez
    43. Aranzazu Diaz de Bustamante
    44. Elena Domínguez-Garrido
    45. Rocío Eirós
    46. Mar√≠a Carmen Fari√Īas
    47. María J. Fernandez-Nestosa
    48. Uxía Fernández-Robelo
    49. Amanda Fernández-Rodríguez
    50. Tania Fern√°ndez-Villa
    51. Manuela Gago-Domínguez
    52. Belén Gil-Fournier
    53. Javier Gómez- Arrue
    54. Beatriz Gonz√°lez √Ālvarez
    55. Fernan Gonzalez Bernaldo de Quirós
    56. Anna Gonz√°lez-Neira
    57. Javier Gonz√°lez-Pe√Īas
    58. Juan F. Gutiérrez-Bautista
    59. María José Herrero
    60. Antonio Herrero-Gonzalez
    61. María A. Jimenez-Sousa
    62. María Claudia Lattig
    63. Anabel Liger Borja
    64. Rosario Lopez-Rodriguez
    65. Esther Mancebo
    66. Caridad Martín- López
    67. Vicente Martín
    68. Oscar Martinez-Nieto
    69. Iciar Martinez-Lopez
    70. Michel F. Martinez-Resendez
    71. √Āngel Martinez-Perez
    72. Juliana F. Mazzeu
    73. Eleuterio Merayo Macías
    74. Pablo Minguez
    75. Victor Moreno Cuerda
    76. Silviene F. Oliveira
    77. Eva Ortega-Paino
    78. Mara Parellada
    79. Estela Paz-Artal
    80. Ney P.C. Santos
    81. Patricia Pérez- Matute
    82. Patricia Perez
    83. M. Elena Pérez-Tomás
    84. Teresa Perucho
    85. Mel·lina Pinsach- Abuin
    86. Guillermo Pita
    87. Ericka N. Pompa-Mera
    88. Gloria L. Porras-Hurtado
    89. Aurora Pujol
    90. Soraya Ramiro León
    91. Salvador Resino
    92. Marianne R. Fernandes
    93. Emilio Rodríguez-Ruiz
    94. Fernando Rodriguez-Artalejo
    95. José A. Rodriguez-Garcia
    96. Francisco Ruiz-Cabello
    97. Javier Ruiz-Hornillos
    98. Pablo Ryan
    99. José Manuel Soria
    100. Juan Carlos Souto
    101. Eduardo Tamayo
    102. Alvaro Tamayo-Velasco
    103. Juan Carlos Taracido-Fernandez
    104. Alejandro Teper
    105. Lilian Torres-Tobar
    106. Miguel Urioste
    107. Juan Valencia-Ramos
    108. Zuleima Y√°√Īez
    109. Ruth Zarate
    110. Itziar de Rojas
    111. Agustín Ruiz
    112. Pascual S√°nchez
    113. Luis Miguel Real
    114. SCOURGE Cohort Group
    115. Encarna Guillen-Navarro
    116. Carmen Ayuso
    117. Esteban Parra
    118. José A. Riancho
    119. Augusto Rojas-Martinez
    120. Carlos Flores
    121. Pablo Lapunzina
    122. √Āngel Carracedo
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The authors conduct a valuable GWAS meta-analysis for COVID-19 hospitalization in admixed American populations and prioritized risk variants and genes. The evidence supporting the claims of the authors is incomplete. The work will be of interest to scientists studying the genetic basis of COVID pathogenesis.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  5. Relationship between circulating FSH levels and body composition and bone health in patients with prostate cancer who undergo androgen deprivation therapy. The BLADE study

    This article has 19 authors:
    1. M Bergamini
    2. A Dalla Volta
    3. C Palumbo
    4. S Zamboni
    5. L Triggiani
    6. M Zamparini
    7. M Laganà
    8. L Rinaudo
    9. N Di Meo
    10. I Caramella
    11. R Bresciani
    12. F Valcamonico
    13. P Borghetti
    14. A Guerini
    15. D Farina
    16. A Antonelli
    17. C Simeone
    18. G Mazziotti
    19. A Berruti
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The authors observed a positive correlation between FSH and fat mass, as well as a negative association with the appendicular lean mass/fat mass ratio. These valuable findings in male subjects within a hypogonadal setting following Degarelix treatment imply that FSH might function as a predictor, similar to observations in women. However, it's important to note that the analysis is incomplete, as other major confounding factors such as testosterone were not included.

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    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  6. PCBP2 as an intrinsic aging factor regulates the senescence of hBMSCs through the ROS-FGF2 signaling axis

    This article has 8 authors:
    1. Pengbo Chen
    2. Bo Li
    3. Zeyu Lu
    4. Qingyin Xu
    5. Huoliang Zheng
    6. Shengdan Jiang
    7. Leisheng Jiang
    8. Xinfeng Zheng
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this valuable study, the authors aimed to identify and characterize intrinsic factors that govern the aging process of bone marrow mesenchymal stromal cells (BMSCs), which are believed to be related to osteoporosis. The authors conclude that PCBP2 is an intrinsic aging factor, the decrease of its expression during aging results in cell proliferation activity decrease and cell senescence. The study provides convincing evidence in support of its conclusions.

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    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  7. Tumor Purity-Related Genes for Predicting the Prognosis and Drug Sensitivity of DLBCL Patients

    This article has 5 authors:
    1. Zhenbang Ye
    2. Ning Huang
    3. Yongliang Fu
    4. Rongle Tian
    5. Wenting Huang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The findings in this study are useful and may have practical implications for predicting DLBCL risk subject to further validating the bioinformatics outcomes. We found the approach and data analysis solid. However, some concerns regarding the drug sensitivity prediction and the links between the selected genes for the risk scores have been raised that need to be addressed by further functional works.

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    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  8. Hyperglycemia-induced cathepsin L maturation: Implications for diabetic comorbidities and COVID-19 susceptibility

    This article has 10 authors:
    1. Qiong He
    2. Miao-Miao Zhao
    3. Ming-Jia Li
    4. Xiao-Ya Li
    5. Jian-Min Jin
    6. Ying-Mei Feng
    7. Li Zhang
    8. Wei-Jin Huang
    9. Fang-Yuan Yang
    10. Jin-Kui Yang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study advances our understanding of why diabetes is a risk factor for more severe Covid-19 disease. The authors offer solid evidence that cathepsin L is more active in diabetic individuals, that this higher activity is recapitulated at the cellular level in the presence of high glucose, and that high glucose leads to higher cathepsin L maturation. While not all aspects of the relationship between diabetes and cathepsin L (e.g., effects of metabolic acidosis) have been investigated, the work should be of interest to researchers in diabetes, virology, and immunology.

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    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  9. Dengue Viremia Kinetics and Effects on Platelet Count and Clinical Outcomes: An Analysis of 2340 Patients from Vietnam

    This article has 13 authors:
    1. Nguyen Lam Vuong
    2. Nguyen Than Ha Quyen
    3. Nguyen Thi Hanh Tien
    4. Duong Thi Hue Kien
    5. Huynh Thi Le Duyen
    6. Phung Khanh Lam
    7. Dong Thi Hoai Tam
    8. Tran Van Ngoc
    9. Thomas Jaenisch
    10. Cameron P. Simmons
    11. Sophie Yacoub
    12. Bridget A. Wills
    13. Ronald B. Geskus
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This very interesting study by Vuond and colleagues reports on the kinetics of viremia in a large set of individuals from Vietnam. In the large cohort, all 4 dengue serotypes are represented and the authors try to correlate viraemia measured at various days from illness onset with thrombocytopaenia and severe dengue, according to the WHO 2009 classification scheme. These are fundamental findings and provide compelling evidence of the importance of measuring viremia early in the phase of the disease. These data will help to inform the design of studies of antiviral drugs against dengue.

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    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  10. The effect of combining antibiotics on resistance: A systematic review and meta-analysis

    This article has 6 authors:
    1. Berit Siedentop
    2. Viacheslav N. Kachalov
    3. Christopher Witzany
    4. Matthias Egger
    5. Roger D. Kouyos
    6. Sebastian Bonhoeffer
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is a methodologically state-of-the-art systematic review and meta-analysis of studies that addressed the question of whether the administration of multiple antibiotics simultaneously prevents antibiotic resistance development in individuals. The findings are solid. Rather than providing a precise answer, the synthesis of studies eligible for analysis leads to the conclusion that "our analysis could not identify any benefit or harm of using a higher or a lower number of antibiotics regarding within-patient resistance development." This article is important as it articulates the existing knowledge gap, but also serves as an example to careful future use of the meta-analysis methodology, when existing data just don't allow conclusions.

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    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  11. Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry

    This article has 17 authors:
    1. Wei Q. Deng
    2. Nathan Cawte
    3. Natalie Campbell
    4. Sandi M. Azab
    5. Russell J de Souza
    6. Amel Lamri
    7. Katherine M. Morrison
    8. Stephanie A. Atkinson
    9. Padmaja Subbarao
    10. Stuart E. Turvey
    11. Theo J. Moraes
    12. Koon K. Teo
    13. Piush Mandhane
    14. Meghan B. Azad
    15. Elinor Simons
    16. Guillaume Pare
    17. Sonia S. Anand
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study offers a useful advance by introducing a cord blood DNA methylation score for maternal smoking effects, with the inclusion of diverse cohorts. However, the overall strength of evidence is deemed incomplete, due to concerns regarding low exposure levels, low statistical power, potential overfitting, and the need for clearer descriptions of statistical methods. Building more directly from the existing evidence base, exploring differences between ancestries, and considering additional health outcomes would help to enhance the study.

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    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  12. Measuring changes in Plasmodium falciparum census population size in response to sequential malaria control interventions

    This article has 14 authors:
    1. Kathryn E. Tiedje
    2. Qi Zhan
    3. Shazia Ruybal-Pésantez
    4. Gerry Tonkin-Hill
    5. Qixin He
    6. Mun Hua Tan
    7. Dionne C. Argyropoulos
    8. Samantha L. Deed
    9. Anita Ghansah
    10. Oscar Bangre
    11. Abraham R. Oduro
    12. Kwadwo A. Koram
    13. Mercedes Pascual
    14. Karen P. Day
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study highlights how the diversity of the malaria parasite population diminishes following the initiation of effective control interventions but quickly rebounds as control wanes. The data presented is solid and the work shows how genetic studies could be used to monitor changes in disease transmission.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity
  13. High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection

    This article has 17 authors:
    1. Nguyen Thi Khanh Nhu
    2. Minh-Duy Phan
    3. Steven J. Hancock
    4. Kate M. Peters
    5. Laura Alvarez-Fraga
    6. Brian M. Forde
    7. Stacey B. Andersen
    8. Thyl Miliya
    9. Patrick N.A. Harris
    10. Scott A. Beatson
    11. Sanmarie Schlebusch
    12. Haakon Bergh
    13. Paul Turner
    14. Annelie Brauner
    15. Benita Westerlund-Wikström
    16. Adam D. Irwin
    17. Mark A. Schembri
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents valuable findings characterising the genomic features of E. coli isolated from neonatal meningitis from seven countries, and documents bacterial persistence and reinfection in two case studies. The genomic analyses are solid, although the inclusion of a larger number of isolates from more diverse geographies would have strengthened the generalisability of findings. The work will be of interest to people involved in the management of neonatal meningitis patients, and those studying E. coli epidemiology, diversity, and pathogenesis.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity
  14. The intricate relationship of G-Quadruplexes and bacterial pathogenicity islands

    This article has 2 authors:
    1. Bo Lyu
    2. Qisheng Song
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This fundamental study explores the relationship between guanine-quadruplex structures and pathogenicity islands in 89 bacterial strains representing a range of pathogens. Guanine-quadruplex structures were found to be non-randomly distributed within pathogenicity islands and conserved within the same strains. These compelling findings shed light on the molecular mechanisms of Guanine-quadruplex structure-pathogenicity island interactions and will be of interest to all microbiologists.

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    This article has 8 evaluationsAppears in 2 listsLatest version Latest activity
  15. Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology

    This article has 7 authors:
    1. Won Yeong Park
    2. Jieun Yun
    3. Jinho Shin
    4. Byung Ho Oh
    5. Gilsuk Yoon
    6. Seung-Mo Hong
    7. Ki Hean Kim
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important work by Park et al. demonstrates an open-top two-photon light sheet microscopy (OT-TP-LSM) for lesser invasive evaluation of intraoperative 3D pathology. The authors provide convincing evidence for the effectiveness of this technique investigating various human cancer cells. This article will be of broad interest to biologists and, specifically, pathologists utilizing 3D optical microscopy.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 2 listsLatest version Latest activity
  16. Genetic associations between circulating immune cells and periodontitis highlight the prospect of systemic immunoregulation in periodontal care

    This article has 12 authors:
    1. Xinjian Ye
    2. Yijing Bai
    3. Mengjun Li
    4. Yuhang Ye
    5. Yitong Chen
    6. Bin Liu
    7. Yuwei Dai
    8. Shan Wang
    9. Weiyi Pan
    10. Zhiyong Wang
    11. Yingying Mao
    12. Qianming Chen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The authors analyzed the causative association between circulating immune cells and periodontitis, and reported three risk immune cells related to periodontitis. The significance of the findings is fundamental, which substantially advances our understanding of periodontitis. The strength of evidence is convincing.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  17. Concerted changes in the pediatric single-cell intestinal ecosystem before and after anti-TNF blockade

    This article has 46 authors:
    1. Hengqi Betty Zheng
    2. Benjamin A. Doran
    3. Kyle Kimler
    4. Alison Yu
    5. Victor Tkachev
    6. Veronika Niederlova
    7. Kayla Cribbin
    8. Ryan Fleming
    9. Brandi Bratrude
    10. Kayla Betz
    11. Lorenzo Cagnin
    12. Connor McGuckin
    13. Paula Keskula
    14. Alexandre Albanese
    15. Maria Sacta
    16. Joshua de Sousa Casal
    17. Ruben van Esch
    18. Andrew C. Kwong
    19. Conner Kummerlowe
    20. Faith Taliaferro
    21. Nathalie Fiaschi
    22. Baijun Kou
    23. Sandra Coetzee
    24. Sumreen Jalal
    25. Yoko Yabe
    26. Michael Dobosz
    27. Matthew F. Wipperman
    28. Sara Hamon
    29. George D. Kalliolias
    30. Andrea Hooper
    31. Wei Keat Lim
    32. Sokol Haxhinasto
    33. Yi Wei
    34. Madeline Ford
    35. Lusine Ambartsumyan
    36. David L. Suskind
    37. Dale Lee
    38. Gail Deutsch
    39. Xuemei Deng
    40. Lauren V. Collen
    41. Vanessa Mitsialis
    42. Scott B. Snapper
    43. Ghassan Wahbeh
    44. Alex K. Shalek
    45. Jose Ordovas-Montanes
    46. Leslie S. Kean
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study substantially advances our understanding of pediatric Crohn's disease, mapping the cellular make-up of this disease and how patients respond to treatment. The evidence supporting the conclusions is compelling, with thorough bioinformatic analyses, underpinned by rigorous methodology and data integration. The work will be of broad interest to pediatric clinicians, immunologists and bioinformaticians.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  18. Immune response to the mRNA COVID-19 vaccine in hemodialysis patients: cohort study

    This article has 25 authors:
    1. Yi-Shin Chang
    2. Kai Huang
    3. Jessica M Lee
    4. Christen L Vagts
    5. Christian Ascoli
    6. Md-Ruhul Amin
    7. Mahmood Ghassemi
    8. Claudia M Lora
    9. Russell Edafetanure-Ibeh
    10. Yue Huang
    11. Ruth A Cherian
    12. Nandini Sarup
    13. Samantha R Warpecha
    14. Sunghyun Hwang
    15. Rhea Goel
    16. Benjamin A Turturice
    17. Cody Schott
    18. Montserrat Hernandez
    19. Yang Chen
    20. Julianne Joregensen
    21. Wangfei Wang
    22. Mladen Rasic
    23. Richard M Novak
    24. Patricia W Finn
    25. David L Perkins
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable inventory of immune responses to the BTN162b2 mRNA COVID-19 vaccination in 20 hemodialyses (HD) patients and controls at different time courses. The transcriptomic sequencing data were collected and analyzed using a solid and validated methodology. The data analysis and clinical predictors to predict anti-Spike IgG titers in HD can be a starting point for further studies characterizing the immune dysregulation seen in ESRD.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  19. Activin A marks a novel progenitor cell population during fracture healing and reveals a therapeutic strategy

    This article has 12 authors:
    1. Lutian Yao
    2. Jiawei Lu
    3. Leilei Zhong
    4. Yulong Wei
    5. Tao Gui
    6. Luqiang Wang
    7. Jaimo Ahn
    8. Joel D Boerckel
    9. Danielle Rux
    10. Christina Mundy
    11. Ling Qin
    12. Maurizio Pacifici
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This work is a valuable presentation of sharp-wave-ripple reactivation of hippocampal neural ensemble activity recorded as animals explored two different environments. It attempts to use the fact that the ensemble code remaps between the two mazes to identify the best replay-detection procedures for analyzing this type of data. The reviewers found the evidence for a prescriptive conclusion inadequate, while still appreciating the concept of comparing maze-identity discrimination with replay.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  20. Strong isolation by distance and evidence of population microstructure reflect ongoing Plasmodium falciparum transmission in Zanzibar

    This article has 23 authors:
    1. Sean V. Connelly
    2. Nicholas F. Brazeau
    3. Mwinyi Msellem
    4. Billy E. Ngasala
    5. √Ėzkan Aydemir
    6. Varun Goel
    7. Karamoko Niaré
    8. David J. Giesbrecht
    9. Zachary R. Popkin-Hall
    10. Christopher M. Hennelly
    11. Zackary Park
    12. Ann M. Moormann
    13. John Michael Ong’echa
    14. Robert Verity
    15. Safia Mohammed
    16. Shija J. Shija
    17. Lwidiko E. Mhamilawa
    18. Ulrika Morris
    19. Andreas Mårtensson
    20. Jessica T. Lin
    21. Anders Björkman
    22. Jonathan J. Juliano
    23. Jeffrey A. Bailey
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Connelly and colleagues provide convincing genetic evidence that importation from mainland Tanzania is a major source of Plasmodium falciparum lineages currently circulating in Zanzibar. This study also reveals ongoing local malaria transmission and occasional near-clonal outbreaks in Zanzibar. Overall, this research highlights the role of human movements in maintaining residual malaria transmission in an area targeted for intensive control interventions over the past decades and provides valuable information for epidemiologists and public health professionals.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity