@LaraUrban42's saved articles

Loss of N1-methylation of G37 in tRNA induces ribosome stalling and reprograms gene expression

1. Isao Masuda
2. Jae-Yeon Hwang
3. Thomas Christian
4. Sunita Maharjan
5. Fuad Mohammad
6. Howard Gamper
7. Allen R Buskirk
8. Ya-Ming Hou

• Curated by eLife

  Evaluation Summary:

  This manuscript provides evidence that loss of N1-methylation of G37 of tRNAs in bacteria on depletion of TrmD results in defects in aminoacylation and peptidyl-transfer, leading to ribosome stalling and phenotypes indicating activation of the stringent response.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife