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  1. Loss of N1-methylation of G37 in tRNA induces ribosome stalling and reprograms gene expression

    This article has 8 authors:
    1. Isao Masuda
    2. Jae-Yeon Hwang
    3. Thomas Christian
    4. Sunita Maharjan
    5. Fuad Mohammad
    6. Howard Gamper
    7. Allen R Buskirk
    8. Ya-Ming Hou
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      This manuscript provides evidence that loss of N1-methylation of G37 of tRNAs in bacteria on depletion of TrmD results in defects in aminoacylation and peptidyl-transfer, leading to ribosome stalling and phenotypes indicating activation of the stringent response.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

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