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  1. ATP burst is the dominant driver of antibiotic lethality in Mycobacteria

    This article has 6 authors:
    1. Tejan Lodhiya
    2. Aseem Palande
    3. Anjali Veeram
    4. Gerald Larrouy-Maumus
    5. Dany JV Beste
    6. Raju Mukherjee
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this valuable work, Lodhiya et al. provide evidence that excessive ATP underlies the killing of the model organism Mycobacterium smegmatis by two mechanistically-distinct antibiotics. Clarification of the role(s) of reactive oxygen species and ADP, as well as discrepancies with existing literature, would strengthen the model proposed. The data are generally solid as the authors deploy multiple, orthogonal readouts and methods for manipulating reactive oxygen species and ATP. The work will be of interest to those studying antibiotic mechanisms of action.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity