@drpeterrodgers's saved articles

Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection

1. Nicholas Rinkenberger
2. Michael E Abrams
3. Sumit K Matta
4. John W Schoggins
5. Neal M Alto
6. L David Sibley

• Curated by eLife

  Evaluation Summary:

  Toxoplasma gondii is a widespread parasite of warm blooded animals, with estimates suggesting 2 billion people are currently and chronically infected with this pathogen. Many questions remain as to how humans control and eliminate T. gondii following infection. In this manuscript, Rinkenberger et al. reveal a previously unidentified and understudied host factor, RARRES3 that promotes cell autonomous control of T. gondii in human cells. The precise mechanism of control and its in vivo relevance remain areas for additional work.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Genetic basis and dual adaptive role of floral pigmentation in sunflowers

1. Marco Todesco
2. Natalia Bercovich
3. Amy Kim
4. Ivana Imerovski
5. Gregory L Owens
6. Óscar Dorado Ruiz
7. Srinidhi V Holalu
8. Lufiani L Madilao
9. Mojtaba Jahani
10. Jean-Sébastien Légaré
11. Benjamin K Blackman
12. Loren H Rieseberg

• Curated by eLife

  Evaluation Summary:

  This work identifies the primary genetic mechanism underlying UV-absorbance variation across the geographic range of sunflower (Helianthus annuus) and provides evidence that suggests that abiotic variables, rather than pollinators, may maintain this variation in H. annuus and perhaps Helianthus broadly. While claims about direct links to fitness in natural population remain untested, the authors synthesize an ambitious amount of work from an impressive breadth of methods (from transgenics to ecology) that will be of high interest to ecologists and evolutionary biologists.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Bidirectional synaptic plasticity rapidly modifies hippocampal representations

1. Aaron D Milstein
2. Yiding Li
3. Katie C Bittner
4. Christine Grienberger
5. Ivan Soltesz
6. Jeffrey C Magee
7. Sandro Romani

• Curated by eLife

  Evaluation Summary:

  This manuscript uses a combination of high-quality in vivo electrophysiology and modelling to demonstrate that Behavioural Time Scale Plasticity (BTSP) is bidirectional, and the amplitude and direction of this plasticity are dictated by the current weight of the inputs and not by the correlated activity of pairs of neurons. These findings challenge our current views on synaptic plasticity, which are primarily based on Hebb's concept. In addition, the network model used in this study demonstrates that this type of plasticity can rapidly reshape population activity to respond to environmental clues. This study will be of interest to the broad neuroscience audience and foster new ideas on biological and artificial learning.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

Reviewed by eLife

SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway

1. Shahanshah Khan
2. Mahnoush S Shafiei
3. Christopher Longoria
4. John W Schoggins
5. Rashmin C Savani
6. Hasan Zaki

• Curated by eLife

  Evaluation Summary:

  The identification of a novel role of the spike protein expressed on SARS-CoV-2 in directly evoking the host inflammatory responses has a substantial impact in understanding the molecular mechanism of COVID-19 pathogenesis, which may have implication for development of new therapeutics. The elegant analytic approach conducted herein justifies the major conclusions of this work though several additional steps can be made to validate these claims.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife, ScreenIT

Nanoscape, a data-driven 3D real-time interactive virtual cell environment

1. Shereen R Kadir
2. Andrew Lilja
3. Nick Gunn
4. Campbell Strong
5. Rowan T Hughes
6. Benjamin J Bailey
7. James Rae
8. Robert G Parton
9. John McGhee

Author-sourced capture of pathway knowledge in computable form using Biofactoid

1. Jeffrey V Wong
2. Max Franz
3. Metin Can Siper
4. Dylan Fong
5. Funda Durupinar
6. Christian Dallago
7. Augustin Luna
8. John Giorgi
9. Igor Rodchenkov
10. Özgün Babur
11. John A Bachman
12. Benjamin M Gyori
13. Emek Demir
14. Gary D Bader
15. Chris Sander

Drosophila mechanical nociceptors preferentially sense localized poking

1. Zhen Liu
2. Meng-Hua Wu
3. Qi-Xuan Wang
4. Shao-Zhen Lin
5. Xi-Qiao Feng
6. Bo Li
7. Xin Liang

• Curated by eLife

  Evaluation Summary:

  Liu et al present fascinating findings that significantly extend the understanding of molecular and cellular pathways of mechanical nociception in Drosophila larvae. This work is of very high interest to neuroscientists studying sensory function and its molecular underpinnings with implications for our understanding of acute sensation of painful stimuli. The approach and data are of very high quality and provide unprecedented insight into mechanosensory functions in an intact tissue environment.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Malaria parasites utilize pyrophosphate to fuel an essential proton pump in the ring stage and the transition to trophozoite stage

1. Omobukola Solebo
2. Liqin Ling
3. Jing Zhou
4. Tian-Min Fu
5. Hangjun Ke

• Curated by eLife

  Evaluation Summary:

  This work will be of interest to researchers seeking new ways to target malaria parasites. The work provides insight into the energy requirements of parasites during the first day of their two-day life cycle, a period during which they are significantly resistant to a wide variety of antimalarial drugs, and identifies an essential enzyme that could be targeted in early-stage parasites. The study shows this protein is necessary for normal development and growth of parasites in red blood cells.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Risk of heart disease following treatment for breast cancer – results from a population-based cohort study

1. Haomin Yang
2. Nirmala Bhoo-Pathy
3. Judith S Brand
4. Elham Hedayati
5. Felix Grassmann
6. Erwei Zeng
7. Jonas Bergh
8. Weiwei Bian
9. Jonas F Ludvigsson
10. Per Hall
11. Kamila Czene

• Curated by eLife

  Evaluation Summary:

  This manuscript will be of interest to oncologists, cardiologists, cardio-oncologists, and primary care providers who treat patients with breast cancer and adds to the growing body of literature that identifies the increased risk for cardiotoxicity associated with breast cancer treatment and does so at the general population level. The results of this study are interesting and supported by the data provided, however they must be interpreted with caution as the database utilized includes intended treatment regimens (chemotherapy, radiotherapy) rather than the confirmed treatments patients received.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Reorganization of postmitotic neuronal chromatin accessibility for maturation of serotonergic identity

1. Xinrui L Zhang
2. William C Spencer
3. Nobuko Tabuchi
4. Meagan M Kitt
5. Evan S Deneris

• Curated by eLife

  Evaluation Summary:

  This paper will be of interest to developmental biologists who study the gene regulatory mechanisms necessary for induction and maintenance of postmitotic neuronal identity. The study generated a useful resource of genomic data and provided new insights into the dynamic regulation of accessible chromatin regions in post-mitotic serotonin (5-HT) neurons of the mouse hindbrain. This work proposes two transcription factors (Pet1, Lmx1b) as necessary for establishment and maintenance of accessible chromatin regions in serotonin (5-HT) neurons. The study is a major technical achievement but some of the central claims are not yet fully demonstrated.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Recurrent neural networks enable design of multifunctional synthetic human gut microbiome dynamics

1. Mayank Baranwal
2. Ryan L Clark
3. Jaron Thompson
4. Zeyu Sun
5. Alfred O Hero
6. Ophelia S Venturelli

• Curated by eLife

  Evaluation Summary:

  The ultimate goal of this work is to apply machine learning to learn from experimental data on temporal dynamics and functions of microbial communities to predict their future behavior and design new communities with desired functions. Using a significant amount of experimental data, the authors suggest that their method outperforms a commonly used approach. Overall, the work is potentially of broad interest to those working on microbiome prediction and design.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

A-type FHFs mediate resurgent currents through TTX-resistant voltage-gated sodium channels

1. Yucheng Xiao
2. Jonathan W Theile
3. Agnes Zybura
4. Yanling Pan
5. Zhixin Lin
6. Theodore R Cummins

• Curated by eLife

  eLife assessment

  This is an exciting and important study that constitutes a major advance in the molecular understanding of resurgent Na current. Reproducing resurgent current by expression of two proteins has never been done. Here, the authors have for the first time molecularly reconstituted Na channels that produce resurgent Na current. Not only do these experiments satisfactorily and convincingly address a long-standing question in the field, but they also open the door to molecular manipulation of this current, potentially of significant practical use given the proposed role of the current in several disorders and disease states, including pain. The work will be of interest to many neuroscientists.

Reviewed by eLife