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  1. Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific manner

    This article has 9 authors:
    1. Anika Shimonty
    2. Fabrizio Pin
    3. Matt Prideaux
    4. Gang Peng
    5. Joshua R Huot
    6. Hyeonwoo Kim
    7. Clifford J Rosen
    8. Bruce M Spiegelman
    9. Lynda F Bonewald
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The study presents a valuable finding on sexually-dimorphic patterns of osteocyte transcriptomics and low calcium diet-induce bone loss. The evidence supporting the claims of the authors regarding the protective role of Irisin/FNDC5-deficiency in lactation and low-calcium diet in female mice is incomplete, due to the relatively modest phenotypes observed and the insufficient link between Irisin/FNDC5 and calcium homeostasis or milk production.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 3 listsLatest version Latest activity