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  1. High-resolution mapping of the period landscape reveals polymorphism in cell cycle frequency tuning

    This article has 6 authors:
    1. Zhengda Li
    2. Shiyuan Wang
    3. Meng Sun
    4. Minjun Jin
    5. Daniel Khain
    6. Qiong Yang
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      This paper uses microfluidics and Xenopus extracts to investigate the effects of mitotic feedbacks on the cell cycle period. It is shown that the inhibition of G2 regulatory positive feedback loops does not reduce the tunability of the cell cycle oscillations, while interference with PP2A phosphatase can completely block of the cell cycle. The experiments are well-conducted and the results should be of interest to researchers interested in the cell cycle, specifically in the regulation of mitosis.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife

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