Reading List

A list by Biophysics Colab

Articles that are being read by Biophysics Colab.

1340 articlesLast updated

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  4. Novel sterol binding domains in bacteria

    1. Liting Zhai
    2. Amber C Bonds
    3. Clyde A Smith
    4. Hannah Oo
    5. Jonathan Chiu-Chun Chou
    6. Paula V Welander
    7. Laura MK Dassama

    • Curated by eLife

      eLife assessment

      This is a valuable contribution to our understanding of how some bacteria can transport sterols from the cytoplasm to the outer membrane. Though much remains to be tested and explored, the data and analyses presented here provide solid evidence for the genetic and physical interaction of BstA/B/C with bacterially-produced sterols. The manuscript will be of interest to scientists focusing on the characterization of novel bacterial proteins and those studying lipid transport and acquisition in bacterial pathogens.

    Reviewed by eLife

    9 evaluationsAppears in 2 listsLatest version Latest activity

  7. Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel

    1. Peter R Strege
    2. Luke M Cowan
    3. Constanza Alcaino
    4. Amelia Mazzone
    5. Christopher A Ahern
    6. Lorin S Milescu
    7. Gianrico Farrugia
    8. Arthur Beyder

    • Curated by eLife

      eLife Assessment:

      This manuscript presents a biophysical study of the nature of the mechanosensitivity of voltage-gated sodium channels. The identification of a voltage-independent mechanosensitive step is well founded, the proposal that this step is the intracellular gate is plausible speculation. It is expected to be of interest to scientists studying the physical basis of mechanosensitivity in electrophysiology.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 2 listsLatest version Latest activity

  11. Aminomethanesulfonic acid illuminates the boundary between full and partial agonists of the pentameric glycine receptor

    1. Josip Ivica
    2. Hongtao Zhu
    3. Remigijus Lape
    4. Eric Gouaux
    5. Lucia G Sivilotti

    • Curated by eLife

      Evaluation Summary:

      Ivica et al. provide both functional and structural characterization of a relatively unstudied glycine receptor agonist that is structurally in between a full and partial agonist. The combination of cryogenic electron microscopy and electrophysiological approaches allows for complementary structural and functional investigations into the criteria that determine ligand efficacy at the glycine receptor. This manuscript will be of interest to both biophysical and pharmacological investigations of ligand-gated ion channels.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 2 listsLatest version Latest activity

  15. Structure of V-ATPase from citrus fruit

    1. Yong Zi Tan
    2. Kristine A. Keon
    3. Rana Abdelaziz
    4. Peter Imming
    5. Waltraud Schulze
    6. Karin Schumacher
    7. John L. Rubinstein
    Appears in 1 listLatest version

  16. Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter

    1. Colin D. Kinz-Thompson
    2. Maria Louisa Lopez-Redondo
    3. Christopher Mulligan
    4. David B. Sauer
    5. Jennifer J. Marden
    6. Jinmei Song
    7. Emad Tajkhorshid
    8. John F. Hunt
    9. David L. Stokes
    10. Joseph A. Mindell
    11. Da-Neng Wang
    12. Ruben L. Gonzalez
    Appears in 1 listLatest version

  18. Tracing the substrate translocation mechanism in P-glycoprotein

    1. Theresa Gewering
    2. Deepali Waghray
    3. Kristian Parey
    4. Hendrik Jung
    5. Nghi NB Tran
    6. Joel Zapata
    7. Pengyi Zhao
    8. Hao Chen
    9. Dovile Januliene
    10. Gerhard Hummer
    11. Ina Urbatsch
    12. Arne Moeller
    13. Qinghai Zhang

    • Curated by eLife

      eLife assessment

      P-glycoprotein is a major ABC-transporter that exports drugs used in chemotherpay and effects the pharmacokinetics of other drugs. Here the authors have determined cryo-EM structures of drug complexes in previously unforeseen outward-facing conformations. These convincing findings are mechanistically important and reveal potential regions to be exploited by rational-based drug design.

    Reviewed by eLife

    9 evaluationsAppears in 2 listsLatest version Latest activity

  19. Conformational fingerprinting of allosteric modulators in metabotropic glutamate receptor 2

    1. Brandon Wey-Hung Liauw
    2. Arash Foroutan
    3. Michael R Schamber
    4. Weifeng Lu
    5. Hamid Samareh Afsari
    6. Reza Vafabakhsh

    • Curated by eLife

      Evaluation Summary:

      The authors advance our understanding of the molecular underpinnings of allostery in GPCRs by showing the effects of allosteric modulators of mGluR2 on receptor conformation at distinct sites in the presence and absence of orthosteric modulators. This is important as drugs and drug candidates acting outside the site where the orthosteric or endogenous ligands bind are harder to identify. This work provides insights into allosteric changes at the level of individual receptors and provides a new path for drug discovery and is this of interest to colleagues studying GPCRs in health and disease.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer 2 and Reviewer #3 agreed to share their name with the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 2 listsLatest version Latest activity
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