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A list by Biophysics Colab

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  1. ULTRAFAST STRUCTURAL CHANGES DIRECT THE FIRST MOLECULAR EVENTS OF VISION

    1. Thomas Gruhl
    2. Tobias Weinert
    3. Matthew Rodrigues
    4. Christopher J Milne
    5. Giorgia Ortolani
    6. Karol Nass
    7. Eriko Nango
    8. Saumik Sen
    9. Philip J M Johnson
    10. Claudio Cirelli
    11. Antonia Furrer
    12. Sandra Mous
    13. Petr Skopintsev
    14. Daniel James
    15. Florian Dworkowski
    16. Petra BĂĄth
    17. Demet Kekilli
    18. Dmitry Ozerov
    19. Rie Tanaka
    20. Hannah Glover
    21. Camila Bacellar
    22. Steffen BrĂĽnle
    23. Cecilia M Casadei
    24. Azeglio D Diethelm
    25. Dardan Gashi
    26. Guillaume Gotthard
    27. Ramon Guixà-González
    28. Yasumasa Joti
    29. Victoria Kabanova
    30. Gregor Knopp
    31. Elena Lesca
    32. Pikyee Ma
    33. Isabelle Martiel
    34. Jonas MĂĽhle
    35. Shigeki Owada
    36. Filip Pamula
    37. Daniel Sarabi
    38. Oliver Tejero
    39. Ching-Ju Tsai
    40. Niranjan Varma
    41. Anna Wach
    42. SĂ©bastien Boutet
    43. Kensuke Tono
    44. Przemyslaw Nogly
    45. Xavier Deupi
    46. So Iwata
    47. Richard Neutze
    48. Jörg Standfuss
    49. Gebhard FX Schertler
    50. Valerie Panneels
    Appears in 1 listLatest version

  6. Mechanism of dual pharmacological correction and potentiation of human CFTR

    1. Chi Wang
    2. Zhengrong Yang
    3. Blaine J. Loughlin
    4. Haijin Xu
    5. Guido Veit
    6. Sergey Vorobiev
    7. Oliver B. Clarke
    8. Fan Jiang
    9. Yaohui Li
    10. Shikha Singh
    11. Zachary Rich
    12. Elizabeth R. Menten
    13. Robert A. Grassucci
    14. Wei Wang
    15. Allison Mezzell
    16. Ziao Fu
    17. Kam-Ho Wong
    18. Jing Wang
    19. Diana R. Wetmore
    20. R. Bryan Sutton
    21. Christie G. Brouillette
    22. Ina L. Urbatsch
    23. John C. Kappes
    24. Gergely L. Lukacs
    25. Joachim Frank
    26. John F. Hunt
    Appears in 1 listLatest version

  8. Structural genomics of the human dopamine receptor system

    1. Peiyu Xu
    2. Sijie Huang
    3. Brian E. Krumm
    4. Youwen Zhuang
    5. Chunyou Mao
    6. Yumu Zhang
    7. Yue Wang
    8. Xi-Ping Huang
    9. Yong-Feng Liu
    10. Xinheng He
    11. Huadong Li
    12. Wanchao Yin
    13. Yi Jiang
    14. Yan Zhang
    15. Bryan L. Roth
    16. H. Eric Xu
    Appears in 1 listLatest version

  10. Structure of mycobacterial respiratory complex I

    1. Yingke Liang
    2. Alicia Plourde
    3. Stephanie A. Bueler
    4. Jun Liu
    5. Peter Brzezinski
    6. Siavash Vahidi
    7. John L. Rubinstein
    Appears in 1 listLatest version

  15. Intracellular Helix-Loop-Helix Domain Modulates Inactivation Kinetics of Mammalian TRPV5 and TRPV6 Channels

    1. Lisandra Flores-Aldama
    2. Daniel Bustos
    3. Deny Cabezas-Bratesco
    4. Wendy Gonzalez
    5. Sebastian E. Brauchi

    • Curated by Biophysics Colab

      Evaluation statement (1 September 2023)

      Flores-Aldama and colleagues set out to identify molecular determinants of fast inactivation in the TRPV6 ion channel, a mechanism not observed in the closely related TRPV5 channel. The work focuses on a helix-loop-helix (HLH) motif, located at the interface between several important regions for channel gating. Using molecular dynamics simulations and analysis of mutations, the authors identify pairs of amino acid residues in a structural triad formed by the HLH, S2-S3 linker, and transmembrane domains, which show different conformations in the available TRPV5 and TRPV6 cryo-EM structures. An important aspect of the study is that some of the structural hypotheses were derived from an evolutionary analysis of sequences from orthologues of both channels, demonstrating the value of this type of analysis.

      Biophysics Colab considers this to be a convincing study and recommends it to scientists interested in the molecular determinants of ion channel gating.

      (This evaluation by Biophysics Colab refers to the version of record for this work, which is linked to and has been revised from the original preprint following peer review.)

    Reviewed by Biophysics Colab

    3 evaluationsAppears in 4 listsLatest version Latest activity
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