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  1. Small molecule inhibitors of the NorA multidrug efflux pump potentiate antibiotic activity by binding the outward-open conformation

    This article has 19 authors:
    1. Janine L. Gray
    2. Elizabeth V. K. Ledger
    3. Tiffany Suwatthee
    4. Thomas J. Burden
    5. Konstantina Arvaniti
    6. Amber Sefton
    7. Lydia E. Papagora
    8. Thomas B. Clarke
    9. Jennifer Riley
    10. Erika G. Pinto
    11. Fraser Cunningham
    12. Ian H. Gilbert
    13. David Gray
    14. Da-Neng Wang
    15. Kevin D. Read
    16. Thomas Lanyon-Hogg
    17. Nathaniel J. Traaseth
    18. Andrew M. Edwards
    19. Edward W. Tate
    This article has no evaluationsAppears in 1 listLatest version
  2. Active regulation of the epidermal growth factor receptor by the membrane bilayer

    This article has 6 authors:
    1. Shwetha Srinivasan
    2. Xingcheng Lin
    3. Xuyan Chen
    4. Raju Regmi
    5. Bin Zhang
    6. Gabriela S Schlau-Cohen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors describe an interesting approach to studying the dynamics and function of membrane proteins in different lipid environments. The important findings have theoretical and practical implications beyond the study of EGFR to all membrane signalling proteins. The evidence supporting the conclusions is convincing, based on the use of a nanodisk system to study membrane proteins in vitro, combined with state-of-the-art single-molecule FRET. The work will be of broad interest to cell biologists and biochemists.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity