Reading list

Molecular insights into the modulation of the 5HT _2A receptor by serotonin, psilocin, and the G protein subunit Gqα

1. Niklas Viohl
2. Ali Asghar Hakami Zanjani
3. Himanshu Khandelia

Parametrically guided design of beta barrels and transmembrane nanopores using deep learning

1. David Edwin Kim
2. Joseph L Watson
3. David Juergens
4. Sagardip Majumder
5. Stacey R. Gerben
6. Alex Kang
7. Asim K. Bera
8. Xinting Li
9. David Baker

Stabilised D ₂ R G-protein coupled receptor oligomers identify multi-state β-arrestin complexes

1. Katie L. Sharrocks
2. Francesca Fanelli
3. Yewei Lui
4. Annabelle J. Milner
5. Wu Yining
6. Bernadette Byrne
7. Aylin C. Hanyaloglu

Biased agonism of carvedilol in the beta1-adrenergic receptor is governed by conformational exclusion

1. Layara Akemi Abiko
2. Ivana Petrovic
3. Meltem Tatli
4. Samit Desai
5. Henning Stahlberg
6. Anne Spang
7. Stephan Grzesiek

Ideal efficacy photoswitches for TRPC4/5 channels harness high potency for spatiotemporally-resolved control of TRPC function in live tissues

1. Markus Müller
2. Konstantin Niemeyer
3. Navin K. Ojha
4. Sebastian A. Porav
5. Deivanayagabarathy Vinayagam
6. Nicole Urban
7. Fanny Büchau
8. Katharina Oleinikov
9. Mazen Makke
10. Claudia C. Bauer
11. Aidan V. Johnson
12. Stephen P. Muench
13. Frank Zufall
14. Dieter Bruns
15. Yvonne Schwarz
16. Stefan Raunser
17. Trese Leinders-Zufall
18. Robin S. Bon
19. Michael Schaefer
20. Oliver Thorn-Seshold

Functional properties of a disease mutation for migraine in Kv2.1/6.4 channels

1. Debanjan Tewari
2. Christian Sattler
3. Klaus Benndorf

Selective Activation of GPCRs: Molecular Dynamics Shows Siponimod Binds but Fails to Activate S1PR2 Unlike S1PR1

1. Kumari Soniya
2. Chanukya Nanduru
3. Antarip Halder

From resting state to inactivation: the dynamic journey of the inactivation peptide in Shaker Kv channels

1. Roshan Pandey
2. Tanja Kalstrup
3. Rikard Blunck

Regulation of Kv1.2 redox-sensitive gating by the transmembrane lectin LMAN2

1. Shawn M. Lamothe
2. Damayantee Das
3. Anson A. Wong
4. Yubin Hao
5. Aislinn D. Maguire
6. Bradley J. Kerr
7. Victoria A. Baronas
8. Harley T. Kurata

Transient TELC and transmembrane potential in a laser flashed bacteriorhodopsin purple membrane open flat sheet

1. James Weifu Lee

Cryo-EM Structures of Clostridium perfringens Enterotoxin Bound to its Human Receptor, Claudin-4

1. Sewwandi S. Rathnayake
2. Satchal K. Erramilli
3. Anthony A. Kossiakoff
4. Alex J. Vecchio

Proteostasis Landscapes of Selective versus Poorly Responsive CFTR Variants Reveals Structural Vulnerabilities to Correction

1. Eli Fritz McDonald
2. Minsoo Kim
3. John A Olson
4. Jens Meiler
5. Lars Plate

TRPML1 gating modulation by allosteric mutations and lipids

1. Ninghai Gan
2. Yan Han
3. Weizhong Zeng
4. Youxing Jiang

• Curated by eLife

  eLife Assessment

  Transient receptor potential mucolipin 1 (TRPML1) functions as a lysosomal ion channel whose variants are associated with lysosomal storage disorder mucolipidosis type IV. This important report describes local and global structural changes driven by binding of regulatory phospholipids and by mutations that allosterically cause gain or loss of channel function. Most of the claims related to the allosteric regulation of TRPML1 are convincingly supported by two new cryo-EM structures which are evaluated within the context of previously reported TRPML1 structures, and a proposed allosteric gating mechanism is partially supported by functional electrophysiology results.

Reviewed by eLife

Ion and water permeation through Claudin-10b paracellular channels

1. Alessandro Berselli
2. Giulio Alberini
3. Fabio Benfenati
4. Luca Maragliano

N -Glycosylation of MRS2 balances aerobic and anaerobic energy production by reducing rapid mitochondrial Mg ²⁺ influx in conditions of high glucose or impaired respiratory chain function

1. Min Peng
2. Neal D. Mathew
3. Vernon E. Anderson
4. Marni J. Falk
5. Eiko Nakamaru-Ogiso

FKBP12-BOUND CALCINEURIN CONTROL TMEM16A ACTIVITY

1. María Luisa Guzmán-Hernández
2. Miriam Huerta
3. Ana E. López-Romero
4. Rita Morán-Zendejas
5. Abigail Betanzos
6. Patricia Pérez-Cornejo
7. Jorge Arreola

Electrical and G-protein Regulation of CaV2.2 (N-type) Channels

1. Michelle Nilsson
2. Kaiqian Wang
3. Teresa Mínguez-Viñas
4. Marina Angelini
5. Stina Berglund
6. Riccardo Olcese
7. Antonios Pantazis

The fully activated open state of KCNQ1 controls the cardiac “fight-or-flight” response

1. Panpan Hou
2. Lu Zhao
3. Ling Zhong
4. Jingyi Shi
5. Hong Zhan Wang
6. Junyuan Gao
7. Huilin Liu
8. Joan Zuckerman
9. Ira S. Cohen
10. Jianmin Cui

Identification of key residues in Bacillus subtilis germinant receptor protein GerAB involved in spore water uptake

1. Longjiao Chen
2. Houdijn Beekhuis
3. Christina van den Bosch
4. Gianni Vinay
5. George Korza
6. Jocelyne Vreede
7. Peter Setlow
8. Stanley Brul

CryoEM Structure of the human THIK-1 K2P K ⁺ Channel Reveals a Lower ‘Y-gate’ Regulated by Lipids and Anaesthetics

1. Karin EJ Rödström
2. Bisher Eymsh
3. Peter Proks
4. Mehtab S Hayre
5. Christian Madry
6. Anna Rowland
7. Simon Newstead
8. Thomas Baukrowitz
9. Marcus Schewe
10. Stephen J Tucker