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  5. Structural insights into CXCR4 modulation and oligomerization

    1. Kei Saotome
    2. Luke L. McGoldrick
    3. Jo-Hao Ho
    4. Trudy F. Ramlall
    5. Sweta Shah
    6. Michael J. Moore
    7. Jee Hae Kim
    8. Raymond Leidich
    9. William C. Olson
    10. Matthew C. Franklin
    Appears in 1 listLatest version

  10. The mechanism of mammalian proton-coupled peptide transporters

    1. Simon M Lichtinger
    2. Joanne L Parker
    3. Simon Newstead
    4. Philip C Biggin

    • Curated by eLife

      eLife assessment

      This study provides valuable information on the mechanism of PepT2 through enhanced-sampling molecular dynamics, backed by cell-based assays, highlighting the importance of protonation of selected residues for the function of a proton-coupled oligopeptide transporter (hsPepT2). The molecular dynamics approaches are convincing, but with limitations that could be addressed in the manuscript, including lack of incorporation of a protonation coordinate in the free energy landscape, possibility of protonation of the substrate, errors with the chosen constant pH MD method for membrane proteins, dismissal of hysteresis emerging from the MEMENTO method, and the likelihood of other residues being affected by peptide binding. Some changes to the presentation could be considered, including a better description of pKa calculations and the inclusion of error bars in all PMFs. Overall, the findings will appeal to structural biologists, biochemists, and biophysicists studying membrane transporters.

    Reviewed by eLife

    5 evaluationsAppears in 3 listsLatest version Latest activity

  11. TMEM16 and TMEM63/OSCA proteins share a conserved potential to permeate ions and phospholipids

    1. Augustus J. Lowry
    2. Pengfei Liang
    3. Y.C. Serena Wan
    4. Zhen-Ming Pei
    5. Huanghe Yang
    6. Yang Zhang

    • Curated by eLife

      eLife assessment

      This manuscript finds evidence for a latent capability in several members of the TMEM16 and OSCA/TMEM family of ion channels for lipid scramblase activity. The authors demonstrate that the introduction of lysine mutations in evolutionarily conserved areas of TM4 can confer constitutive ion conduction and scramblase activity. Although the significance and scope of the work are important, the strength of the evidence is incomplete and could be improved.

    Reviewed by eLife

    5 evaluationsAppears in 3 listsLatest version Latest activity

  12. The conformational landscape of human transthyretin revealed by cryo-EM

    1. Benjamin Basanta
    2. Karina Nugroho
    3. Nicholas L. Yan
    4. Gabriel M. Kline
    5. Evan T. Powers
    6. Felix J. Tsai
    7. Mengyu Wu
    8. Althea Hansel-Harris
    9. Jason S. Chen
    10. Stefano Forli
    11. Jeffrey W. Kelly
    12. Gabriel C. Lander
    Appears in 1 listLatest version

  17. Cryo-EM structures of human cone visual pigments

    1. Qi Peng
    2. Jian Li
    3. Haihai Jiang
    4. Xinyu Cheng
    5. Qiuyuan Lu
    6. Sili Zhou
    7. Yuting Zhang
    8. Sijia Lv
    9. Shuangyan Wan
    10. Tingting Yang
    11. Yixiang Chen
    12. Wei Zhang
    13. Weiwei Nan
    14. Tong Che
    15. Yanyan Li
    16. Hongfei Liao
    17. Jin Zhang
    Appears in 1 listLatest version
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