Reading List

A list by Biophysics Colab

Articles that are being read by Biophysics Colab.

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  7. Structural insights into CXCR4 modulation and oligomerization

    1. Kei Saotome
    2. Luke L. McGoldrick
    3. Jo-Hao Ho
    4. Trudy F. Ramlall
    5. Sweta Shah
    6. Michael J. Moore
    7. Jee Hae Kim
    8. Raymond Leidich
    9. William C. Olson
    10. Matthew C. Franklin
    Appears in 1 listLatest version

  11. Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants

    1. Balázs István Tóth
    2. Bahar Bazeli
    3. Annelies Janssens
    4. Erika Lisztes
    5. Márk Racskó
    6. Balázs Kelemen
    7. Mihály Herczeg
    8. Tamás Milán Nagy
    9. Katalin E Kövér
    10. Argha Mitra
    11. Attila Borics
    12. Tamás Bíró
    13. Thomas Voets

    • Curated by eLife

      eLife Assessment

      This manuscript presents valuable findings showing that rapamycin directly activates the cool-sensing ion channel, TRPM8, acting through a different binding site than other small-molecule cooling agents such as menthol. The use of Ca2+-imaging, electrophysiology, and computational biology provides solid evidence to support the finding. The authors also present a novel NMR-based method to help identify details of the binding site interactions. In this revised version, some analysis and the presentation have been corrected and improved. Their findings provide insights into TRP channel pharmacology and may indicate previously unknown physiological effects or therapeutic mechanisms of the immunosuppressant, rapamycin.

    Reviewed by eLife

    9 evaluationsAppears in 2 listsLatest version Latest activity

  12. The mechanism of mammalian proton-coupled peptide transporters

    1. Simon M Lichtinger
    2. Joanne L Parker
    3. Simon Newstead
    4. Philip C Biggin

    • Curated by eLife

      eLife assessment

      This study provides important insight into the mechanisms of proton-coupled oligopeptide transporters. It uses enhanced-sampling molecular dynamics (MD), backed by cell-based assays, revealing the importance of protonation of selected residues for PepT2 function. The simulation approaches are convincing, using long MD simulations, constant-pH MD and free energy calculations. Overall, the work has led to findings that will appeal to structural biologists, biochemists, and biophysicists studying membrane transporters.

    Reviewed by eLife

    10 evaluationsAppears in 2 listsLatest version Latest activity

  13. TMEM16 and OSCA/TMEM63 proteins share a conserved potential to permeate ions and phospholipids

    1. Augustus J Lowry
    2. Pengfei Liang
    3. Mo Song
    4. Yuichun Wan
    5. Zhen-Ming Pei
    6. Huanghe Yang
    7. Yang Zhang

    • Curated by eLife

      eLife Assessment

      This important study advances our understanding of the mechanisms controlling lipid flux and ion permeation in the TMEM16 and OSCA/TMEM63 family channels. The study provides compelling new evidence indicating that side chains along the TM4/6 interface play a key role in gating lipid and ion fluxes in these channels. The authors suggest that the transmembrane channel/scramblase family proteins may have originally functioned as scramblases but lost this capacity over evolution.

    Reviewed by eLife

    10 evaluationsAppears in 2 listsLatest version Latest activity

  14. The conformational landscape of human transthyretin revealed by cryo-EM

    1. Benjamin Basanta
    2. Karina Nugroho
    3. Nicholas L. Yan
    4. Gabriel M. Kline
    5. Evan T. Powers
    6. Felix J. Tsai
    7. Mengyu Wu
    8. Althea Hansel-Harris
    9. Jason S. Chen
    10. Stefano Forli
    11. Jeffrey W. Kelly
    12. Gabriel C. Lander
    Appears in 1 listLatest version

  19. Cryo-EM structures of human cone visual pigments

    1. Qi Peng
    2. Jian Li
    3. Haihai Jiang
    4. Xinyu Cheng
    5. Qiuyuan Lu
    6. Sili Zhou
    7. Yuting Zhang
    8. Sijia Lv
    9. Shuangyan Wan
    10. Tingting Yang
    11. Yixiang Chen
    12. Wei Zhang
    13. Weiwei Nan
    14. Tong Che
    15. Yanyan Li
    16. Hongfei Liao
    17. Jin Zhang
    Appears in 1 listLatest version

  20. Harnessing AlphaFold to reveal hERG channel conformational state secrets

    1. Khoa Ngo
    2. Pei-Chi Yang
    3. Vladimir Yarov-Yarovoy
    4. Colleen E Clancy
    5. Igor Vorobyov

    • Curated by eLife

      eLife Assessment

      This valuable study uses AlphaFold2 to guide the structural modelling of different states of the human voltage-gated potassium channel KV11.1, a key pharmacological drug target. Follow-up molecular dynamics and drug-docking simulations, combined with experimental characterization, offer convincing evidence supporting the models. The work shows potential for improving drug potency predictions in ion channel pharmacology.

    Reviewed by eLife

    9 evaluationsAppears in 2 listsLatest version Latest activity
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