Reading List

Allosteric Cholesterol Site in Glycine Receptors Characterized through Molecular Simulations

1. Farzaneh Jalalypour
2. Rebecca J. Howard
3. Erik Lindahl

PIEZO1 regulates leader cell formation and cellular coordination during collective keratinocyte migration

1. Jinghao Chen
2. Jesse R. Holt
3. Elizabeth L. Evans
4. John S. Lowengrub
5. Medha M. Pathak

Cryo-EM structure of the tetra-phosphorylated R-domain in Ycf1 reveals key interactions for transport regulation

1. Rodolpho S. A. de Carvalho
2. Md Shamiul I. Rasel
3. Nitesh K. Khandelwal
4. Thomas M. Tomasiak

Stability of N-type inactivation and the coupling between N-type and C-type inactivation in the Aplysia Kv1 channel

1. Tokunari Iwamuro
2. Kazuki Itohara
3. Yasuo Furukawa

Structural insights into sphingosine 1-phosphate receptor 4 activation

1. Wei Gao
2. Shiyi Gan
3. Mengting Zhang
4. Asuka Inoue
5. Mengting Xie
6. Huan He
7. Huan Zhu
8. Shanshan Guo
9. Chen Qiu
10. Di Chang
11. Jinling Yu
12. Zhuo Deng
13. Fang Ye
14. Shiliang Li
15. Jian Zhang
16. Zhenjiang Zhao
17. Mengzhu Xue
18. Bernard Ofosuhene
19. Yufang Xu
20. Honghuang Lin
21. Xuhong Qian
22. Lili Zhu
23. Yang Du
24. Honglin Li

Distinct roles of the major binding residues in the cation-binding pocket of MelB

1. Parameswaran Hariharan
2. Amirhossein Bakhtiiari
3. Ruibin Liang
4. Lan Guan

A versatile functional interaction between electrically silent KV subunits and KV7 potassium channels

1. Vijay Renigunta
2. Nermina Xhaferri
3. Imran Gousebasha Shaikh
4. Jonathan Schlegel
5. Rajeshwari Bisen
6. Ilaria Sanvido
7. Theodora Kalpachidou
8. Kai Kummer
9. Dominik Oliver
10. Michael G. Leitner
11. Moritz Lindner

Magnesium Transporter MgtA revealed as a Dimeric P-type ATPase

1. Rilee Zeinert
2. Fei Zhou
3. Pedro Franco
4. Jonathan Zöller
5. Henry J. Lessen
6. L. Aravind
7. Julian D. Langer
8. Alexander J. Sodt
9. Gisela Storz
10. Doreen Matthies

Domain coupling in activation of a family C GPCR

1. Naomi R. Latorraca
2. Sam Sabaat
3. Chris H. Habrian
4. Julia Bleier
5. Cherise Stanley
6. Colin D. Kinz-Thompson
7. Susan Marqusee
8. Ehud Y. Isacoff

Multimodal intrinsic activation of GPCRs in ultrastable plasma membrane nanodomains

1. Gabriele Kockelkoren
2. Jens Carstensen
3. Line Lauritsen
4. Eleftheria Kazepidou
5. Asger Tonnesen
6. Christopher G. Shuttle
7. Paulina S. Kaas
8. Ankur Gupta
9. Artù Breuer
10. Søren G. F. Rasmussen
11. Loïc Duffet
12. Tony Warne
13. Tommaso Patriarchi
14. Christopher G. Tate
15. Mark Uline
16. Dimitrios Stamou

CTFFIND5 provides improved insight into quality, tilt, and thickness of TEM samples

1. Johannes Elferich
2. Lingli Kong
3. Ximena Zottig
4. Nikolaus Grigorieff

• Curated by eLife

  eLife Assessment

  This valuable work presents the latest version of CTFFIND, which is the most popular software for determination of the contrast transfer function (CTF) in cryo-electron microscopy. CTFFIND5 estimates and considers acquisition geometry and sample thickness, which leads to improved CTF determination. The paper describes compelling evidence that CTFFIND5 finds better CTF parameters than previous methods, in particular for tilted samples (e.g. for cryo-electron tomography) or where thickness is an issue (e.g. cellular samples, or electron microscopy at low voltages).

Reviewed by eLife

Depletion of membrane cholesterol modifies structure, dynamic and activation of Nav1.7

1. Simone Albani
2. Vishal Sudha Bhagavath Eswaran
3. Alessia Piergentili
4. Paulo Cesar Telles de Souza
5. Angelika Lampert
6. Giulia Rossetti

AlphaFold-SFA: accelerated sampling of cryptic pocket opening, protein-ligand binding and allostery by AlphaFold, slow feature analysis and metadynamics

1. Shray Vats
2. Raitis Bobrovs
3. Pär Söderhjelm
4. Soumendranath Bhakat

Reviewed by Biophysics Colab

Structural analysis and conformational dynamics of a holo-adhesion GPCR reveal interplay between extracellular and transmembrane domains

1. Szymon P. Kordon
2. Kristina Cechova
3. Sumit J. Bandekar
4. Katherine Leon
5. Przemysław Dutka
6. Gracie Siffer
7. Anthony A. Kossiakoff
8. Reza Vafabakhsh
9. Demet Araç

Chlorpromazine inhibits EAG1 channels by altering the coupling between the PAS, CNBH and pore domains

1. Mahdi Ghorbani
2. Ze-Jun Wang
3. Xi Chen
4. Purushottam B. Tiwari
5. Jeffery B. Klauda
6. Tinatin I. Brelidze

Building predictive Markov State Models of ion channel permeation from Molecular Dynamics

1. Luigi Catacuzzeno
2. Maria Vittoria Leonardi
3. Fabio Franciolini
4. Carmen Domene
5. Antonio Michelucci
6. Simone Furini

Structural Determinants for Activity of the Antidepressant Vortioxetine at Human and Rodent 5-HT ₃ receptors

1. Uriel López-Sánchez
2. Lachlan Jake Munro
3. Lucy Kate Ladefoged
4. Anders Juel Pedersen
5. Christian C. Nielsen
6. Signe M. Lyngby
7. Delphine Baud
8. Sarah C. R. Lummis
9. Benny Bang-Andersen
10. Birgit Schiøtt
11. Christophe Chipot
12. Guy Schoehn
13. Jacques Neyton
14. Francois Dehez
15. Hugues Nury
16. Anders S. Kristensen

Structural shifts in TolC facilitate Efflux-Mediated β-lactam resistance

1. Isik Kantarcioglu
2. Ilona K. Gaszek
3. Tandac F. Guclu
4. M. Sadik Yildiz
5. Ali Rana Atilgan
6. Erdal Toprak
7. Canan Atilgan

A genetically-encoded nanobody sensor reveals conformational diversity in β-arrestins orchestrated by distinct seven transmembrane receptors

1. Parishmita Sarma
2. Vendula Nagy Marková
3. Nashrah Zaidi
4. Annu Dalal
5. Sudha Mishra
6. Manish K. Yadav
7. Gargi Mahajan
8. Nabarun Roy
9. Paul Miclea
10. Josef Lazar
11. Arun K. Shukla

Turgor and the conformational pathway for MscS recovery

1. Andriy Anishkin
2. Sergei Sukharev