Reading list

Macromolecular condensation is unlikely to buffer intracellular osmolality

1. Alan R. Kay

Architecture and rearrangements of a sperm-specific Na+/H+ exchanger

1. Sandipan Chowdhury
2. Kamalendu Pal

MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor

1. Iqra Sohail
2. Suli-Anne Laurin
3. Gunnar Kleinau
4. Vidicha Chunilal
5. Zeynep Cansu Uretmen Kagiali
6. Martin J. Lohse
7. Patrick Scheerer
8. Michel Bouvier
9. Peter McCormick
10. Paolo Annibale
11. Heike Biebermann

Alternating Access of a Neurotransmitter:Sodium Symporter Bacterial Homolog Determined from AlphaFold2 Ensembles and DEER Spectroscopy

1. Alexandra C. Schwartz
2. Richard A. Stein
3. Eva Gil-Iturbe
4. Matthias Quick
5. Hassane S. Mchaourab

Exploring the Influence of Pore Shape on Conductance and Permeation

1. David Seiferth
2. Philip C. Biggin

Lipid-dependent conformational dynamics of bacterial ATP-binding cassette transporter Sav1866

1. Shadi A Badiee
2. Jeevapani Hettige
3. Mahmoud Moradi

Multiresolution molecular dynamics simulations reveal the interplay between conformational variability and functional interactions in membrane-bound cytochrome 2B4

1. Sungho Bosco Han
2. Jonathan Teuffel
3. Goutam Mukherjee
4. Rebecca C. Wade

Molecular basis of proton-sensing by G protein-coupled receptors

1. Matthew K. Howard
2. Nicholas Hoppe
3. Xi-Ping Huang
4. Christian B. Macdonald
5. Eshan Mehrota
6. Patrick Rockefeller Grimes
7. Adam Zahm
8. Donovan D. Trinidad
9. Justin English
10. Willow Coyote-Maestas
11. Aashish Manglik

Bi-directional allosteric pathway in NMDA receptor activation and modulation

1. Paula A. Bender
2. Subhajit Chakraborty
3. Ryan J. Durham
4. Vladimir Berka
5. Elisa Carrillo
6. Vasanthi Jayaraman

Unlocking TAS2R14 activation through intricate multi-ligand binding networks

1. Xiaolong Hu
2. Weizhen Ao
3. Mingxin Gao
4. Lijie Wu
5. Yuan Pei
6. Shenhui Liu
7. Qianqian Sun
8. Junlin Liu
9. Longquan Jiang
10. Yiran Wu
11. Xin Wang
12. Yan Li
13. Qiwen Tan
14. Jie Cheng
15. Fan Yang
16. Chi Yang
17. Jinpeng Sun
18. Tian Hua
19. Zhi-Jie Liu

Structural and Dynamic Insights into the Biased Signaling Mechanism of the Human Kappa Opioid Receptor

1. Chiyo Suno-Ikeda
2. Ryo Nishikawa
3. Riko Suzuki
4. Seiya Iwata
5. Tomoyo Takai
6. Takaya Ogura
7. Mika Hirose
8. Akitoshi Inoue
9. Eri Asai
10. Ryoji Kise
11. Yukihiko Sugita
12. Takayuki Kato
13. Hiroshi Nagase
14. Tsuyoshi Saitoh
15. Kota Katayama
16. Asuka Inoue
17. Hideki Kandori
18. Takuya Kobayashi
19. Ryoji Suno

Selectivity and evolution of Aqp10 in solute permeability influenced by pore molecular weight

1. Ayumi Nagashima
2. Kazutaka Ushio
3. Hidenori Nishihara
4. Jin Akimoto
5. Akira Kato
6. Tadaomi Furuta

Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter

1. Parveen Goyal
2. KanagaVijayan Dhanabalan
3. Mariafrancesca Scalise
4. Rosmarie Friemann
5. Cesare Indiveri
6. Renwick C.J. Dobson
7. Kutti R. Vinothkumar
8. Subramanian Ramaswamy

• Curated by eLife

  eLife assessment

  This valuable work provides novel insights into the substrate binding mechanism of a tripartite ATP-independent periplasmic (TRAP) transporter. The structural analysis is convincing, but evidence to support some of the conclusions regarding the mechanism is incomplete. This study will be of interest to the membrane transport and bacterial biochemistry communities.

Reviewed by eLife

Molecular characterization of Rft1, an ER membrane protein associated with congenital disorder of glycosylation RFT1-CDG

1. Eri Hirata
2. Ken-taro Sakata
3. Grace I. Dearden
4. Faria Noor
5. Indu Menon
6. George N. Chiduza
7. Anant K. Menon

Positive allosteric modulation of a GPCR ternary complex

1. Wessel A.C. Burger
2. Christopher J. Draper-Joyce
3. Celine Valant
4. Arthur Christopoulos
5. David M. Thal

Structural insights into the human P2X1 receptor and ligand interactions

1. Felix M. Bennetts
2. Hariprasad Venugopal
3. Alisa Glukhova
4. Jesse I. Mobbs
5. Sabatino Ventura
6. David M. Thal

Intracellular pocket conformations determine signaling through the μ opioid receptor

1. David A. Cooper
2. Joseph DePaolo-Boisvert
3. Stanley A. Nicholson
4. Barien Gad
5. David D. L. Minh

Next Generation Neuropeptide Y Receptor Small Molecule Agonists Inhibit Mosquito Biting Behavior

1. Emely V. Zeledon
2. Leigh A. Baxt
3. Tanweer A. Khan
4. Mayako Michino
5. Michael Miller
6. David J. Huggins
7. Caroline S. Jiang
8. Leslie B. Vosshall
9. Laura B. Duvall

Structural basis for CCR6 modulation by allosteric antagonists

1. David Jonathan Wasilko
2. Brian S. Gerstenberger
3. Kathleen A. Farley
4. Wei Li
5. Jennifer Alley
6. Mark E. Schnute
7. Ray J. Unwalla
8. Jorge Victorino
9. Kimberly K. Crouse
10. Ru Ding
11. Parag V. Sahasrabudhe
12. Fabien Vincent
13. Richard K. Frisbie
14. Alpay Dermenci
15. Andrew Flick
16. Chulho Choi
17. Gary Chinigo
18. James J. Mousseau
19. John I. Trujillo
20. Philippe Nuhant
21. Prolay Mondal
22. Vincent Lombardo
23. Daniel Lamb
24. Barbara J. Hogan
25. Gurdeep Singh Minhas
26. Elena Segala
27. Christine Oswald
28. Ian W. Windsor
29. Seungil Han
30. Mathieu Rappas
31. Robert M. Cooke
32. Matthew F. Calabrese
33. Gabriel Berstein
34. Atli Thorarensen
35. Huixian Wu

Reviewed by PREreview

Design, synthesis and pharmacological characterization of the first photoswitchable small-molecule agonist for the Atypical Chemokine Receptor 3

1. Sophie Bérenger
2. Justyna M. Adamska
3. Francesca Deflorian
4. Chris de Graaf
5. Christie B. Palmer
6. Martyna Szpakowska
7. Andy Chevigné
8. Iwan J. P. de Esch
9. Barbara Zarzycka
10. Henry F. Vischer
11. Maikel Wijtmans
12. Rob Leurs