Reading list

Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter

1. Steven J Middleton
2. Sigurbjörn Markússon
3. Mikael Åkerlund
4. Justin C. Deme
5. Mandy Tseng
6. Wenqianglong Li
7. Sana R Zuberi
8. Gabriel Kuteyi
9. Peter Sarkies
10. Georgios Baskozos
11. Jimena Perez-Sanchez
12. Harry L Hébert
13. Sylvanus Toikumo
14. Adham Farah
15. Susan Maxwell
16. Yin Y Dong
17. Henry R Kranzler
18. John E Linley
19. Blair H Smith
20. Susan M. Lea
21. Joanne L Parker
22. Valeriya Lyssenko
23. Simon Newstead
24. David L Bennett

Simulation-based survey of TMEM16 family reveals that robust lipid scrambling requires an open groove

1. Christina Alexandra Stephens
2. Niek van Hilten
3. Lisa Zheng
4. Michael Grabe

Re-evaluation of some popular CRAC channel inhibitors – structurally similar but mechanistically different?

1. Yasin Gökçe
2. Sinayat Mahzabeen
3. Joshua Ghoorahoo
4. Matthew Thomas Harper
5. Nazmi Yaras
6. Taufiq Rahman

Twist is the key to the gating of mechanosensitive ion channel NOMPC

1. Jingze Duan
2. Chen Song

• Curated by eLife

  eLife Assessment

  This valuable study uses steered molecular dynamics simulations to interrogate force transmission in the mechanosensitive NOMPC channel, which plays roles including soft-touch perception, auditory function, and locomotion. The finding that the ankyrin spring transmits force through torsional rather than compression forces may help understand the entire TRP channel family. The evidence is, however, considered to be still incomplete. It could be strengthened by testing how the channel responds to different twisting and compressional force magnitudes over longer simulation times to see a full gating motion, or to prove that the partial or initial motion observed relates to physiological gating. Experimental validation of reduced mechano-sensitivity through mutagenesis of proposed ankyrin/TRP domain coupling interactions would be best to enhance the manuscript.

Reviewed by eLife

Assembly and dynamics of the outer membrane exopolysaccharide transporter PelBC of Pseudomonas aeruginosa

1. Marius Benedens
2. Cristian Rosales Hernandez
3. Sabine A.P. Straathof
4. Jennifer Loschwitz
5. Otto Berninghausen
6. Giovanni Maglia
7. Roland Beckmann
8. Alexej Kedrov

Structural basis for the access and binding of resolvin D1 (RvD1) to formyl peptide receptor 2 (FPR2/ALX), a class A GPCR

1. Brian Mun
2. Peter Obi
3. Christopher T. Szlenk
4. Senthil Natesan

Identification of the orphan GPR25 as a receptor of the chemokine CXCL17

1. Wen-Feng Hu
2. Jie Yu
3. Juan-Juan Wang
4. Ru-Jiao Sun
5. Yong-Shan Zheng
6. Teng Zhang
7. Ya-Li Liu
8. Zeng-Guang Xu
9. Zhan-Yun Guo

Mechanisms of peptide agonist dissociation and deactivation of adhesion G-protein-coupled receptors

1. Keya Joshi
2. Yinglong Miao

G protein selectivity profile of GPR56/ADGRG1 and its effect on downstream effectors

1. Raida Jallouli
2. Ana Lilia Moreno Salinas
3. Andréanne Laniel
4. Brian Holleran
5. Charlotte Avet
6. Joan Jacob
7. Trang Hoang
8. Christine Lavoie
9. Kendra S Carmon
10. Michel Bouvier
11. Richard Leduc

Subunit-specific conductance of single HCN pacemaker channels at femtosiemens resolution

1. Klaus Benndorf
2. Uta Enke
3. Debanjan Tewari
4. Jana Kusch
5. Haoran Liu
6. Han Sun
7. Ralf Schmauder
8. Christian Sattler

Elucidating the Differential Impacts of Equivalent Gating-Charge Mutations in Voltage-Gated Sodium Channels

1. Eslam Elhanafy
2. Amin Akbari Ahangar
3. Rebecca Roth
4. Tamer M. Gamal El-Din
5. John R Bankston
6. Jing Li

De novo Design of A Fusion Protein Tool for GPCR Research

1. Kaixuan Gao
2. Xin Zhang
3. Jia Nie
4. Hengyu Meng
5. Weishe Zhang
6. Boxue Tian
7. Xiangyu Liu

Maltodextrin Transport in the Extremely Thermophilic, Lignocellulose Degrading Bacterium Anaerocellum bescii (f. Caldicellulosiruptor bescii)

1. Hansen Tjo
2. Virginia Jiang
3. Jerelle A. Joseph
4. Jonathan M. Conway

ADPKD variants in the PKD2 pore helix cause structural collapse of the gate and distinct forms of channel dysfunction

1. Orhi Estarte Palomero
2. Paul G. DeCaen

Molecular basis of the urate transporter URAT1 inhibition by gout drugs

1. Yang Suo
2. Justin G. Fedor
3. Han Zhang
4. Kalina Tsolova
5. Xiaoyu Shi
6. Kedar Sharma
7. Shweta Kumari
8. Mario Borgnia
9. Peng Zhan
10. Wonpil Im
11. Seok-Yong Lee

Protocol for Simulating the Effect of THz Electromagnetic Field on Ion Channels

1. Lingfeng Xue
2. Zigang Song
3. Qi Ouyang
4. Chen Song

Mechanisms of urate transport and uricosuric drugs inhibition in human URAT1

1. Wenjun Guo
2. Miao Wei
3. Yunfeng Li
4. Jiaxuan Xu
5. Jiahe Zang
6. Yuezhou Chen
7. Lei Chen

Structural basis of the excitatory amino acid transporter 3 substrate recognition

1. Biao Qiu
2. Olga Boudker

Allosteric modulation of proton binding confers Cl ^- activation and glutamate selectivity to vesicular glutamate transporters

1. Bart Borghans
2. Daniel Kortzak
3. Piersilvio Longo
4. Jan-Philipp Machtens
5. Christoph Fahlke

A novel mechanism for the uptake of enterobactin-chelated ferric ions by the mitochondria and subsequent reduction to ferrous ions inside

1. Abeg Dutta
2. Anutthaman Parthasarathy
3. Namasivayam Ganesh Pandian