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  1. Projection-specific integration of convergent thalamic and retrosplenial signals in the presubicular head direction cortex

    This article has 8 authors:
    1. Louis Richevaux
    2. Dongkyun Lim
    3. Mérie Nassar
    4. Léa Dias Rodrigues
    5. Constanze Mauthe
    6. Ivan Cohen
    7. Nathalie Sol-Foulon
    8. Desdemona Fricker
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Richevaux and colleagues conducted a valuable study that investigated the integration of thalamic and retrosplenial inputs in the dorsal presubiculum, an essential hippocampal region involved in spatial navigation and memory. Through ex vivo optogenetic electrophysiological experiments, they discovered that many presubicular pyramidal cells receive convergent inputs from both the anterior thalamus and the retrosplenial cortex. These solid findings provide a potential cellular mechanism for anchoring the brain's internal compass to external landmarks, shedding light on how the brain integrates spatial information with an animal's sense of its position in space.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 3 listsLatest version Latest activity
  2. Eye-specific synaptic clustering through activity-dependent stabilization and punishment mechanisms in the developing visual system

    This article has 2 authors:
    1. Chenghang Zhang
    2. Colenso M. Speer
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study is a useful analysis of the organization of synaptic proteins of a developing synapse in the binocular path visual system and how it is impacted by manipulations in activity. The original images collected by STORM microscopy are state-of-the-art in terms of the high-resolution view of the protein components of a synapse in intact tissue. However, the analysis is incomplete and does not fully support several of the conclusions of the study.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 3 listsLatest version Latest activity
  3. Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues

    This article has 31 authors:
    1. Adam Glaser
    2. Jayaram Chandrashekar
    3. Joshua Vasquez
    4. Cameron Arshadi
    5. Naveen Ouellette
    6. Xiaoyun Jiang
    7. Judith Baka
    8. Gabor Kovacs
    9. Micah Woodard
    10. Sharmishtaa Seshamani
    11. Kevin Cao
    12. Nathan Clack
    13. Andrew Recknagel
    14. Anna Grim
    15. Pooja Balaram
    16. Emily Turschak
    17. Alan Liddell
    18. John Rohde
    19. Ayana Hellevik
    20. Kevin Takasaki
    21. Lindsey Erion Barner
    22. Molly Logsdon
    23. Chris Chronopoulos
    24. Saskia de Vries
    25. Jonathan Ting
    26. Steve Perlmutter
    27. Brian Kalmbach
    28. Nikolai Dembrow
    29. R. Clay Reid
    30. David Feng
    31. Karel Svoboda
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The ExA-SPIM methodology developed will be important to the field of light sheet microscopy as the new technology provides an impressive field of view making it possible to image the entire expanded mouse brain at cellular and subcellular resolution. The authors provide solid evidence that mostly supports the conclusions. Certain statements were deemed to be overstating the method's capabilities, in particular, the claim of "near isotropic resolution" is not supported by the data as there is a large discrepancy between the x/y and z-resolution. Improved characterization of the new technology and a more expanded discussion of prior work would also be beneficial to the reader.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 3 listsLatest version Latest activity
  4. Leading an urban invasion: risk-sensitive learning is a winning strategy

    This article has 2 authors:
    1. Alexis J Breen
    2. Dominik Deffner
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study uses a multi-pronged empirical and theoretical approach to advance our understanding of how differences in learning relate to differences in the ways that male versus female animals cope with urban environments, and more generally how reversal learning may benefit animals in urban habitats. The work makes an important contribution and parts of the data and analyses are solid, although several of the main claims are only partially supported or overstated and require additional support.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 3 listsLatest version Latest activity
  5. Phasic locus coeruleus activity enhances trace fear conditioning by increasing dopamine release in the hippocampus

    This article has 7 authors:
    1. Jacob H Wilmot
    2. Cassiano R.A.F. Diniz
    3. Ana P. Crestani
    4. Kyle Puhger
    5. Jacob Roshgadol
    6. Lin Tian
    7. Brian J Wiltgen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study enhances our understanding of the brain circuitry responsible for fear conditioning and provides evidence for an under-appreciated role of dopaminergic output projection from the Locus Coeruleus to the dorsal hippocampus in this fear learning. The evidence supporting the conclusion is convincing, although a direct test of dopamine release in the dorsal hippocampus from Locus Coeruleus projections during fear conditioning would strengthen the study. If done, this would likely raise the strength of the evidence to compelling. This paper is of interest to behavioural and neuroscience researchers studying learning, memory, and neural networks.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 3 listsLatest version Latest activity
  6. Dysfunctional Hippocampal-Prefrontal Network Underlies a Multidimensional Neuropsychiatric Phenotype following Early-Life Seizure

    This article has 11 authors:
    1. Rafael Naime Ruggiero
    2. Danilo Benette Marques
    3. Matheus Teixeira Rossignoli
    4. Jana Batista De Ross
    5. Tamiris Prizon
    6. Ikaro Jesus Silva Beraldo
    7. Lezio Soares Bueno-Junior
    8. Ludmyla Kandratavicius
    9. Jose Eduardo Peixoto-Santos
    10. Cleiton Lopes Aguiar
    11. João Pereira Leite
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study assesses anatomical, behavioral, physiological, and neurochemical effects of early-life seizures in rats, describing a striking astrogliosis and deficits in cognition and electrophysiological parameters. The convincing aspects of the paper are the wide range of convergent techniques used to understand the effects of early-life seizures on behavior as well as hippocampal prefrontal cortical dynamics. While reviewers thought that the scope was impressive, there was criticism of the statistical robustness and number of animals used per study arm, as well as the lack of causal manipulations to determine cause-and-effect relationships. This paper will be of interest to neurobiologists, epileptologists, and behavioral scientists.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 3 listsLatest version Latest activity
  7. Astrocytes gate long-term potentiation in hippocampal interneurons

    This article has 10 authors:
    1. Weida Shen
    2. Yejiao Tang
    3. Jing Yang
    4. Linjing Zhu
    5. Wen Zhou
    6. Liyang Xiang
    7. Feng Zhu
    8. Jingyin Dong
    9. Yicheng Xie
    10. Ling-Hui Zeng
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The study presents valuable insights into the regulation of astrocytes in the long-term potentiation of excitatory synapses onto inhibitory interneurons. However, reviewers identified concerns regarding originality and proper acknowledgment of replicated work, representation of interneuron diversity, and the robustness of certain conclusions. The strength of evidence provided is deemed incomplete, necessitating significant revisions for clarity, and accuracy, and to address highlighted concerns.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 3 listsLatest version Latest activity
  8. Enhanced Aversive Signals During Classical Conditioning in Dopamine Axons in Medial Prefrontal Cortex

    This article has 13 authors:
    1. Kenta Abe
    2. Yuki Kambe
    3. Kei Majima
    4. Zijing Hu
    5. Makoto Ohtake
    6. Ali Momennezhad
    7. Hideki Izumi
    8. Takuma Tanaka
    9. Ashley Matunis
    10. Emma Stacy
    11. Takahide Itokazu
    12. Takashi R. Sato
    13. Tatsuo K. Sato
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study shows that distinct midbrain dopaminergic axons in the medial prefrontal cortex respond to aversive and rewarding stimuli and suggest that they are biased toward aversive processing. The use of innovative microprism based two-photon calcium imaging to study single axon heterogeneity is solid, although the experimental design could be optimized to distinguish aversive valence from stimulus salience and identity in this dopamine projection. This work will be of interest to neuroscientists working on neuromodulatory systems, cortical function and decision making.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 3 listsLatest version Latest activity
  9. Genomic stability of Self-inactivating Rabies

    This article has 6 authors:
    1. Ernesto Ciabatti
    2. Ana González-Rueda
    3. Daniel de Malmazet
    4. Hassal Lee
    5. Fabio Morgese
    6. Marco Tripodi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The authors previously developed a tool with the goal of non-toxic trans-synaptic tracing using a modified rabies virus, an important goal for the neuroscience field. The tool has the propensity to accumulate mutations over time that promote toxicity, and the manuscript here describes techniques to avoid these mutations. It remains important to show that the non-mutated virus can serve as an effective trans-synaptic tracing tool.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 3 listsLatest version Latest activity