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  1. Metabolic regulation of misfolded protein import into mitochondria

    This article has 7 authors:
    1. Yuhao Wang
    2. Linhao Ruan
    3. Jin Zhu
    4. Xi Zhang
    5. Alexander Chih-Chieh Chang
    6. Alexis Tomaszewski
    7. Rong Li
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study makes a connection between cellular metabolism and proteostasis through MAGIC, a previously proposed protein quality control pathway of clearance of cytosolic misfolded and aggregated proteins by importing into mitochondria. The authors reveal the role of Snf1, a yeast AMPK, in preventing the import of misfolded proteins to mitochondria for MAGIC controlled by the transcription factor Hap4, depending on the cellular metabolic status. The key message is important, although the evidence for physiological relevance of MAGIC for overall cellular proteostasis and its molecular regulation by Snf1 remains incomplete.

    Reviewed by eLife, Life Science Editors Foundation

    This article has 8 evaluationsAppears in 4 listsLatest version Latest activity
  2. Ras-dependent activation of BMAL2 regulates hypoxic metabolism in pancreatic cancer

    This article has 28 authors:
    1. H. Carlo Maurer
    2. Alvaro Curiel-Garcia
    3. Sam Holmstrom
    4. Pasquale Laise
    5. Carmine F. Palermo
    6. Steven A. Sastra
    7. Anthony Andren
    8. Zhang Li
    9. Tessa LeLarge
    10. Irina Sagalovskiy
    11. Daniel R. Ross
    12. Vilma Rosario
    13. Kate Lu
    14. Ethan Ferraiuolo
    15. Nicholas Spinosa
    16. Winston Wong
    17. Kaitlin Shaw
    18. John A. Chabot
    19. Jeanine Genkinger
    20. Hanina Hibshoosh
    21. Gulam A. Manji
    22. Alina Iuga
    23. Roland M. Schmid
    24. Michael A. Badgley
    25. Kristen Johnson
    26. Andrea Califano
    27. Costas Lyssiotis
    28. Kenneth P. Olive
    This article has no evaluationsAppears in 1 listLatest version
  3. Identification of chemotherapy targets reveals a nucleus-to-mitochondria ROS sensing pathway

    This article has 36 authors:
    1. Junbing Zhang
    2. Claire M. Simpson
    3. Jacqueline Berner
    4. Harrison B. Chong
    5. Jiafeng Fang
    6. Zehra Ordulu Sahin
    7. Tom Weiss-Sadan
    8. Anthony P. Possemato
    9. Stefan Harry
    10. Mariko Takahashi
    11. Tzu-yi Yang
    12. Marianne Richter
    13. Himani Patel
    14. Abby E. Smith
    15. Alexander D. Carlin
    16. Adriaan F. Hubertus de Groot
    17. Konstantin Wolf
    18. Lei Shi
    19. Ting-Yu Wei
    20. Benedikt R. Dürr
    21. Nicholas J. Chen
    22. Tristan Vornbäumen
    23. Nina O. Wichmann
    24. Venkatesh Pooladanda
    25. Yuske Matoba
    26. Shaan Kumar
    27. Eugene Kim
    28. Sara Bouberhan
    29. Esther Olivia
    30. Bo Rueda
    31. Nabeel Bardeesy
    32. Brian Liau
    33. Michael Lawrence
    34. Matt P. Stokes
    35. Sean A. Beausoleil
    36. Liron Bar-Peled
    This article has no evaluationsAppears in 1 listLatest version
  4. Mitochondrial electron transport chain, ceramide, and coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle

    This article has 18 authors:
    1. Alexis Diaz-Vegas
    2. Søren Madsen
    3. Kristen C Cooke
    4. Luke Carroll
    5. Jasmine XY Khor
    6. Nigel Turner
    7. Xin Y Lim
    8. Miro A Astore
    9. Jonathan C Morris
    10. Anthony S Don
    11. Amanda Garfield
    12. Simona Zarini
    13. Karin A Zemski Berry
    14. Andrew P Ryan
    15. Bryan C Bergman
    16. Joseph T Brozinick
    17. David E James
    18. James G Burchfield
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study highlights a potential connection between fatty acid intrusion into myocytes and increases in mitochondrial ceramide that cause deficits in coenzyme Q and consequent insulin resistance. The authors primarily use the L6 myocyte model, which may not fully recapitulate in vivo conditions, however, the manuscript shows compelling data in mice that substantially supports the L6 cell results. Overall, this study provides a strong framework for a compelling pathway of myocyte dysfunction and for continued efforts to test the important hypotheses that are presented.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 3 listsLatest version Latest activity
  5. Drug-induced eRF1 degradation promotes readthrough and reveals a new branch of ribosome quality control

    This article has 19 authors:
    1. Lukas-Adrian Gurzeler
    2. Marion Link
    3. Yvonne Ibig
    4. Isabel Schmidt
    5. Olaf Galuba
    6. Julian Schoenbett
    7. Christelle Gasser-Didierlaurant
    8. Christian N. Parker
    9. Xiaohong Mao
    10. Francis Bitsch
    11. Markus Schirle
    12. Philipp Couttet
    13. Frederic Sigoillot
    14. Jana Ziegelmüller
    15. Anne-Christine Uldry
    16. Wojciech Teodorowicz
    17. Niko Schmiedeberg
    18. Oliver Mühlemann
    19. Jürgen Reinhardt
    This article has no evaluationsAppears in 1 listLatest version
  6. Oncogene-like addiction to aneuploidy in human cancers

    This article has 25 authors:
    1. Vishruth Girish
    2. Asad A. Lakhani
    3. Sarah L. Thompson
    4. Christine M. Scaduto
    5. Leanne M. Brown
    6. Ryan A. Hagenson
    7. Erin L. Sausville
    8. Brianna E. Mendelson
    9. Pranav K. Kandikuppa
    10. Devon A. Lukow
    11. Monet Lou Yuan
    12. Eric C. Stevens
    13. Sophia N. Lee
    14. Klaske M. Schukken
    15. Saron M. Akalu
    16. Anand Vasudevan
    17. Charles Zou
    18. Barbora Salovska
    19. Wenxue Li
    20. Joan C. Smith
    21. Alison M. Taylor
    22. Robert A. Martienssen
    23. Yansheng Liu
    24. Ruping Sun
    25. Jason M. Sheltzer
    This article has no evaluationsAppears in 1 listLatest version
  7. Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS mice

    This article has 7 authors:
    1. Ang Li
    2. Jianxun Yi
    3. Xuejun Li
    4. Li Dong
    5. Lyle W Ostrow
    6. Jianjie Ma
    7. Jingsong Zhou
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The manuscript by Jingsong Zhou and colleagues uncovers why the extraocular muscles (EOMs) are preserved while other muscles undergo degenerative changes in amyotrophic lateral sclerosis (ALS). In this work, the authors have used a mouse model of familial ALS that carries a G93A mutation in the Sod1 gene to demonstrate that NaBu treatment partially restores the integrity of NMJ in the limb and diaphragm muscles of G93A mice. The findings of the study offer important information that EOMs are spared in ALS because they produce protective factors for the NMJ and, more specifically, factors secreted by EOM-derived satellite cells. While most of the experimental approaches are convincing, the use of sodium butyrate (NaBu) in this study needs further investigation, as NaBu might have a variety of biological effects. Overall, this work may help develop future therapeutic interventions for patients with ALS.

    Reviewed by eLife

    This article has 11 evaluationsAppears in 3 listsLatest version Latest activity
  8. Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging

    This article has 22 authors:
    1. James R. Occean
    2. Na Yang
    3. Yan Sun
    4. Marshall S. Dawkins
    5. Rachel Munk
    6. Cedric Belair
    7. Showkat Dar
    8. Carlos Anerillas
    9. Lin Wang
    10. Changyou Shi
    11. Christopher Dunn
    12. Michel Bernier
    13. Nathan L. Price
    14. Julie S. Kim
    15. Chang-Yi Cui
    16. Jinshui Fan
    17. Moitrayee Bhattacharyya
    18. Supriyo De
    19. Manolis Maragkakis
    20. Rafael deCabo
    21. Simone Sidoli
    22. Payel Sen
    This article has no evaluationsAppears in 1 listLatest version