Showing page 1 of 1 pages of list content

  1. Reorganization of postmitotic neuronal chromatin accessibility for maturation of serotonergic identity

    This article has 5 authors:
    1. Xinrui L Zhang
    2. William C Spencer
    3. Nobuko Tabuchi
    4. Meagan M Kitt
    5. Evan S Deneris
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      This paper will be of interest to developmental biologists who study the gene regulatory mechanisms necessary for induction and maintenance of postmitotic neuronal identity. The study generated a useful resource of genomic data and provided new insights into the dynamic regulation of accessible chromatin regions in post-mitotic serotonin (5-HT) neurons of the mouse hindbrain. This work proposes two transcription factors (Pet1, Lmx1b) as necessary for establishment and maintenance of accessible chromatin regions in serotonin (5-HT) neurons. The study is a major technical achievement but some of the central claims are not yet fully demonstrated.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife

    This article has 4 evaluationsAppears in 4 listsLatest version Latest activity