@_LBezares's saved articles

Compressive forces stabilise microtubules in living cells

1. Yuhui Li
2. Ondřej Kučera
3. Damien Cuvelier
4. David M. Rutkowski
5. Mathieu Deygas
6. Dipti Rai
7. Tonja Pavlovič
8. Filipe Nunes Vicente
9. Matthieu Piel
10. Gregory Giannone
11. Dimitrios Vavylonis
12. Anna Akhmanova
13. Laurent Blanchoin
14. Manuel Théry

Phenotyping single-cell motility in microfluidic confinement

1. Samuel A. Bentley
2. Vasileios Anagnostidis
3. Hannah Laeverenz Schlogelhofer
4. Fabrice Gielen
5. Kirsty Y. Wan

• Curated by eLife

  eLife assessment

  This paper reports on the development of an impressive microfluidic platform for the study of motility, and motility transitions, exhibited by single algal cells in circular confinement. Building on previous work that showed a three-state motility repertoire for certain green algae, the present work uses extremely long time series and a variety of physical perturbations to show how those dynamics can be altered by environmental conditions. The work will be of interest to a wide range of scientists studying motility and nonequilibrium dynamics, but its impact would be improved by a more insightful analysis of the voluminous data, with connections to physical principles.

Reviewed by eLife

Electron Cryo-Tomography Structure of Axonemal Doublet Microtubule from Tetrahymena thermophila

1. Sam Li
2. Jose-Jesus Fernandez
3. Amy S. Fabritius
4. David A. Agard
5. Mark Winey

Characterization of cephalic and non-cephalic sensory cell types provides insight into joint photo- and mechanoreceptor evolution

1. Roger Revilla-i-Domingo
2. Vinoth Babu Veedin Rajan
3. Monika Waldherr
4. Günther Prohaczka
5. Hugo Musset
6. Lukas Orel
7. Elliot Gerrard
8. Moritz Smolka
9. Matthias Farlik
10. Robert J. Lucas
11. Florian Raible
12. Kristin Tessmar-Raible

• Curated by eLife

  Evaluation Summary:

  This manuscript presents an investigation of receptors in the trunk of Platynereis annelids that express genes involved in both photoreception (e.g. r-Opsin) and mechanosensation. This is particularly interesting in light of other work in model organisms like flies that uncovered broadly similar results. The authors compare gene expression of fly Johnston Organ cells and mouse hearing cells to the worm receptors. Because Platynereis is distantly related to flies and mice, the authors suggest this "hybrid" sensory receptor could be very old and homologous across many animals. The question of what role r-Opsins play outside of photoreceptors is an interesting one that remains poorly understood.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #4 agreed to share their names with the authors.)

Reviewed by eLife

Desmosomal connectomics of all somatic muscles in an annelid larva

1. Sanja Jasek
2. Csaba Verasztó
3. Emelie Brodrick
4. Réza Shahidi
5. Tom Kazimiers
6. Alexandra Kerbl
7. Gáspár Jékely

• Curated by eLife

  Evaluation Summary:

  This paper is based on digital reconstruction of a serial EM stack of a larva of the annelid Platynereis and presents a complete 3D map of all desmosomes between somatic muscle cells and their attachment partners. This resource is of interest to scientists in several fields: motor control, high-resolution anatomy, and network analyses. With the first comprehensive and complete mapping of muscle-to-body connectivity through desmosomes in an annelid larva, it has the potential to close a missing link and make progress towards understanding in a "holistic" way how a complex neural circuitry controls an equally complex pattern of movement/behavior.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife