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Latest preprint reviews

1. Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronaviruses

   This article has 26 authors:

   1. Rui P Silva
   2. Yimin Huang
   3. Annalee W Nguyen
   4. Ching-Lin Hsieh
   5. Oladimeji S Olaluwoye
   6. Tamer S Kaoud
   7. Rebecca E Wilen
   8. Ahlam N Qerqez
   9. Jun-Gyu Park
   10. Ahmed M Khalil
   11. Laura R Azouz
   12. Kevin C Le
   13. Amanda L Bohanon
   14. Andrea M DiVenere
   15. Yutong Liu
   16. Alison G Lee
   17. Dzifa A Amengor
   18. Sophie R Shoemaker
   19. Shawn M Costello
   20. Eduardo A Padlan
   21. Susan Marqusee
   22. Luis Martinez-Sobrido
   23. Kevin N Dalby
   24. Sheena D'Arcy
   25. Jason S McLellan
   26. Jennifer A Maynard

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Silva and colleagues present useful findings related to the isolation of an anti-S2 antibody that recognizes a previously uncharacterized SARS-CoV2 Spike (S) epitope, adding to the growing repertoire of anti-S antibodies that broadly cross-react against human and zoonotic coronaviruses. The evidence supporting the claims of the authors is solid, although antibody effectiveness as a prophylactic or therapeutic reagent in an animal model would have strengthened the study. The work will be of interest to biologists working to develop pan-coronavirus therapies.

   Reviewed by eLife, ScreenIT

2. Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike protein

   This article has 2 authors:

   1. Pete Heinzelman
   2. Philip A. Romero

   Reviewed by ScreenIT

3. Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors

   This article has 20 authors:

   1. Kanchan Devkota
   2. Matthieu Schapira
   3. Sumera Perveen
   4. Aliakbar Khalili Yazdi
   5. Fengling Li
   6. Irene Chau
   7. Pegah Ghiabi
   8. Taraneh Hajian
   9. Peter Loppnau
   10. Albina Bolotokova
   11. Karla J.F. Satchell
   12. Ke Wang
   13. Deyao Li
   14. Jing Liu
   15. David Smil
   16. Minkui Luo
   17. Jian Jin
   18. Paul V. Fish
   19. Peter J. Brown
   20. Masoud Vedadi

   Reviewed by ScreenIT

4. Killed whole-genome reduced-bacteria surface-expressed coronavirus fusion peptide vaccines protect against disease in a porcine model

   This article has 14 authors:

   1. Denicar Lina Nascimento Fabris Maeda
   2. Debin Tian
   3. Hanna Yu
   4. Nakul Dar
   5. Vignesh Rajasekaran
   6. Sarah Meng
   7. Hassan M. Mahsoub
   8. Harini Sooryanarain
   9. Bo Wang
   10. C. Lynn Heffron
   11. Anna Hassebroek
   12. Tanya LeRoith
   13. Xiang-Jin Meng
   14. Steven L. Zeichner

   Reviewed by ScreenIT

5. Randomized trials - Ivermectin repurposing for COVID-19 treatment of outpatients with mild disease in primary health care centers

   This article has 9 authors:

   1. Rossana Elena Chahla
   2. Luis Medina Ruiz
   3. Teresa Mena
   4. Yolanda Brepe
   5. Paola Terranova
   6. Eugenia Silvana Ortega
   7. Guillermo Gabriel Barrenechea
   8. Daniel Gustavo Goroso
   9. María de los Ángeles Peral de Bruno

   Reviewed by ScreenIT

6. Reanalysis of the Pfizer mRNA BNT162b2 SARS-CoV-2 vaccine data fails to find any increased efficacy following the boost: Implications for vaccination policy and our understanding of the mode of action

   This article has 6 authors:

   1. Allan Saul
   2. Heidi E. Drummer
   3. Nick Scott
   4. Tim Spelman
   5. Brendan S. Crabb
   6. Margaret Hellard

   Reviewed by ScreenIT

7. Severity of SARS-CoV-2 infection as a function of the interferon landscape across the respiratory tract of COVID-19 patients

   This article has 23 authors:

   1. Benedetta Sposito
   2. Achille Broggi
   3. Laura Pandolfi
   4. Stefania Crotta
   5. Roberto Ferrarese
   6. Sofia Sisti
   7. Nicola Clementi
   8. Alessandro Ambrosi
   9. Enju Liu
   10. Vanessa Frangipane
   11. Laura Saracino
   12. Laura Marongiu
   13. Fabio A Facchini
   14. Andrea Bottazzi
   15. Tommaso Fossali
   16. Riccardo Colombo
   17. Massimo Clementi
   18. Elena Tagliabue
   19. Antonio E Pontiroli
   20. Federica Meloni
   21. Andreas Wack
   22. Nicasio Mancini
   23. Ivan Zanoni

   Reviewed by ScreenIT

8. Secondary attack rates of COVID-19 in Norwegian families: a nation-wide register-based study

   This article has 5 authors:

   1. Kjetil Telle
   2. Silje B. Jørgensen
   3. Rannveig Hart
   4. Margrethe Greve-Isdahl
   5. Oliver Kacelnik

   Reviewed by ScreenIT

9. GUIdEStaR (G-quadruplex, uORF, IRES, Epigenetics, Small RNA, Repeats), the integrated metadatabase in conjunction with neural network methods

   This article has 1 author:

   1. Jee Eun Kang

   Reviewed by ScreenIT

10. Low Dose Regimens of BNT162b2 mRNA Vaccine Exceed SARS-Cov-2 Correlate of Protection Estimates for Symptomatic Infection, in those 19-55 Years of Age

    This article has 1 author:

    1. Graham Jurgens

    Reviewed by ScreenIT