ScreenIT

Latest preprint reviews

1. Retrospective study of COVID-19 seroprevalence among tissue donors at the onset of the outbreak before implementation of strict lockdown measures in France

   This article has 7 authors:

   1. Nicolas Germain
   2. Stéphanie Herwegh
   3. Anne-Sophie Hatzfeld
   4. Laurence Bocket
   5. Brigitte Prévost
   6. Pierre-Marie Danzé
   7. Philippe Marchetti

   Reviewed by ScreenIT

2. Do latitude and ozone concentration predict Covid-2019 cases in 34 countries?

   This article has 1 author:

   1. Mark M. Alipio

   Reviewed by ScreenIT

3. Three pictures of COVID-19 behavior in Italy: similar growth and different degrowth

   This article has 3 authors:

   1. A. Feoli
   2. A. L. Iannella
   3. E. Benedetto

   Reviewed by ScreenIT

4. Scrutinizing the spread of COVID-19 in Madagascar

   This article has 2 authors:

   1. Stephan Narison
   2. Stavros Maltezos

   Reviewed by ScreenIT

5. The kinetic variations of anti-nucleocapsid antibody in SARS-CoV-2 infection

   This article has 7 authors:

   1. Shoji Kawada
   2. Atsushi Ogata
   3. Yasuhiro Kato
   4. Masashi Okamoto
   5. Yuta Yamaguchi
   6. Takayoshi Morita
   7. Atsushi Kumanogoh

   Reviewed by ScreenIT

6. First Data-Set on SARS-CoV-2 Detection for Istanbul Wastewaters in Turkey

   This article has 6 authors:

   1. Bilge Alpaslan Kocamemi
   2. Halil Kurt
   3. Sabri Hacıoglu
   4. Cevdet Yaralı
   5. Ahmet Mete Saatci
   6. Bekir Pakdemirli

   Reviewed by ScreenIT

7. SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets

   This article has 12 authors:

   1. Palur V Raghuvamsi
   2. Nikhil K Tulsian
   3. Firdaus Samsudin
   4. Xinlei Qian
   5. Kiren Purushotorman
   6. Gu Yue
   7. Mary M Kozma
   8. Wong Y Hwa
   9. Julien Lescar
   10. Peter J Bond
   11. Paul A MacAry
   12. Ganesh S Anand

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: This is a timely and interesting exploration of the interaction between the Spike protein of SARS-CoV-2, the virus responsible for the COVID-19 pandemic, and the ACE2 receptor using hydrogen deuterium exchange mass spectrometry and molecular dynamics simulations. The Spike protein consists of two sub-domains S1 and S2 with the S1 needing to be cleaved-off so the S2 can become the fusion protein responsible for getting the SARS-CoV-2 into the cell. Structures are available but they do not shed light on how the protease furin can access the cleavage site between S1 and S2 in order to begin the process of fusion. The results suggest that the Spike-ACE2 interaction induces extremely long-range allosteric effects on the Spike protein that could trigger proteolysis of the Spike protein. Specifically, when ACE2 binds to the Spike protein, a conformational change occurs near the S1/S2 cleavage site, exposing it and likely making it more susceptible to furin cleavage. The binding also dampens exchange in the stalk region of the Spike protein. The authors refer to these regions as "dynamic hotspots in the pre-fusion state". The results of this work have implications for the development of small molecule inhibitors.

     In general, the work is timely, and the results will be of interest to many in the field. The major conclusions of the work are generally supported by the results.

   Reviewed by eLife, ScreenIT

8. The effect of whey protein on viral infection and replication of SARS-CoV-2 and pangolin coronavirus in vitro

   This article has 14 authors:

   1. Huahao Fan
   2. Bixia Hong
   3. Yuqian Luo
   4. Qi Peng
   5. Liqin Wang
   6. Xiangshu Jin
   7. Yangzhen Chen
   8. Yunjia Hu
   9. Yi Shi
   10. Tong Li
   11. Hui Zhuang
   12. Yi-Hua Zhou
   13. Yigang Tong
   14. Kuanhui Xiang

   Reviewed by ScreenIT

9. Forecasting PPE Consumption during a Pandemic: The Case of Covid-19

   This article has 13 authors:

   1. Kristian Lum
   2. James Johndrow
   3. April Cardone
   4. Barry Fuchs
   5. Cody E. Cotner
   6. Olivia Jew
   7. Ravi B. Parikh
   8. Michael Draugelis
   9. ThaiBinh Luong
   10. Asaf Hanish
   11. Gary E. Weissman
   12. Christian Terwiesch
   13. Kevin G. Volpp

   Reviewed by ScreenIT

10. A bacterial artificial chromosome (BAC)-vectored noninfectious replicon of SARS-CoV-2

    This article has 5 authors:

    1. Yang Zhang
    2. Wuhui Song
    3. Shuiye Chen
    4. Zhenghong Yuan
    5. Zhigang Yi

    Reviewed by Rapid Reviews Infectious Diseases, ScreenIT