Review Commons

Latest preprint reviews

1. Kinetic regulation of kinesin’s two motor domains coordinates its stepping along microtubules

   This article has 5 authors:

   1. Yamato Niitani
   2. Kohei Matsuzaki
   3. Erik Jonsson
   4. Ronald D Vale
   5. Michio Tomishige

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides compelling evidence that kinesin's stepping mechanism is governed by strain-induced conformational changes in its nucleotide-binding pockets. Using pre-steady state kinetics and single-molecule assays, the authors demonstrate that the neck linker's conformation differentially modulates nucleotide affinity and detachment rates, establishing an asynchronous chemo-mechanical cycle that prevents simultaneous detachment. Supported by cryo-EM structural data, the work presents an important advance in our understanding of kinesin's hand-over-hand movement.

     [Editors' note: this paper was reviewed by Review Commons.]

   Reviewed by eLife, Review Commons

2. Hydroxyurea induces ER stress and cytoplasmic protein aggregation

   This article has 8 authors:

   1. Ana Sánchez-Molina
   2. Manuel Bernal
   3. Joel D. Posligua-García
   4. Antonio J. Pérez-Pulido
   5. Laura de Cubas
   6. Elena Hidalgo
   7. Silvia Salas-Pino
   8. Rafael R. Daga

   Reviewed by Review Commons

3. Whole genome CRISPR screens identify a LRRK2-regulated pathway for extracellular tau uptake by human neurons

   This article has 14 authors:

   1. Lewis D. Evans
   2. Alessio Strano
   3. Eleanor Tuck
   4. Ashley Campbell
   5. James Smith
   6. Christy Hung
   7. Tiana S. Behr
   8. Bernardino Ghetti
   9. Benjamin Ryskeldi-Falcon
   10. Emre Karakoc
   11. Francesco Iorio
   12. Alastair Reith
   13. Andrew R. Bassett
   14. Frederick J. Livesey

   Reviewed by Review Commons

4. Early coordination of cell migration and cardiac fate determination during mammalian gastrulation

   This article has 8 authors:

   1. Shayma Abukar
   2. Peter A Embacher
   3. Alessandro Ciccarelli
   4. Sunita Varsani-Brown
   5. Isabel G W North
   6. Jamie A Dean
   7. James Briscoe
   8. Kenzo Ivanovitch

   Reviewed by Review Commons

5. Non-muscle myosin II regulates presynaptic actin assemblies and neuronal mechanobiology in Drosophila

   This article has 3 authors:

   1. Biljana Ermanoska
   2. Jonathan Baets
   3. Avital A. Rodal

   Reviewed by Review Commons

6. GLE1 dysfunction compromises cellular homeostasis, spatial organization, and peripheral axon branching

   This article has 17 authors:

   1. T Zárybnický
   2. S Lindfors
   3. S Metso
   4. Z Szabo
   5. R Valtonen
   6. M Tulppo
   7. J Magga
   8. S Saarimäki
   9. S Bläuer
   10. I Miinalainen
   11. R Kerkelä
   12. J Väänänen
   13. R Kivelä
   14. FP Zhang
   15. P Sipilä
   16. R Hinttala
   17. S Kuure

   Reviewed by Review Commons

7. CCDC32 stabilizes clathrin-coated pits and drives their invagination

   This article has 12 authors:

   1. Ziyan Yang
   2. Changsong Yang
   3. Zheng Huang
   4. Peiliu Xu
   5. Yueping Li
   6. Lu Han
   7. Linyuan Peng
   8. Xiangying Wei
   9. John Pak
   10. Tatyana Svitkina
   11. Sandra L Schmid
   12. Zhiming Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The manuscript presents a valuable finding that CCDC32, beyond its reported role in AP2 assembly, follows AP2 to the plasma membrane and regulates clathrin-coated pit assembly and dynamics. The authors further identify an alpha-helical region within CCDC32 that is essential for its interaction with AP2 and its cellular function. While live-cell and ultrastructural imaging data are solid, future biochemical studies will be needed to confirm the proposed CCDC32-AP2 interaction.

     [Editors' note: this paper was reviewed by Review Commons.]

   Reviewed by eLife, Review Commons

8. Loss of ErbB3 redirects Integrin β1 from early endosomal recycling to secretion in extracellular vesicles

   This article has 8 authors:

   1. Dorival Mendes Rodrigues-Junior
   2. Ana Rosa Sáez-Ibáñez
   3. Takeshi Terabayashi
   4. Nina Daubel
   5. Taija Mäkinen
   6. Olof Idevall-Hagren
   7. Aristidis Moustakas
   8. Ingvar Ferby

   Reviewed by Review Commons

9. Bystander activation across a TAD boundary supports a cohesin-dependent hub-model for enhancer function

   This article has 6 authors:

   1. Iain Williamson
   2. Katy A. Graham
   3. Hannes Becher
   4. Robert E. Hill
   5. Wendy A. Bickmore
   6. Laura A. Lettice

   Reviewed by Review Commons

10. Plasmacytoid dendritic cell sensing of hepatitis E virus is shaped by both viral and host factors

    This article has 13 authors:

    1. Garima Joshi
    2. Elodie Décembre
    3. Jacques Brocard
    4. Claire Montpellier
    5. Martin Ferrié
    6. Omran Allatif
    7. Ann-Kathrin Mehnert
    8. Johann Pons
    9. Delphine Galiana
    10. Viet Loan Dao Thi
    11. Nolwenn Jouvenet
    12. Laurence Cocquerel
    13. Marlène Dreux

    Reviewed by Review Commons