Review Commons

Latest preprint reviews

1. A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei

   This article has 21 authors:

   1. Mohammad Zeeshan
   2. Igor Blatov
   3. Ryuji Yanase
   4. David JP Ferguson
   5. Sarah L Pashley
   6. Zeinab Chahine
   7. Yoshiki Yamaryo-Botté
   8. Akancha Mishra
   9. Baptiste Marche
   10. Suhani Bhanvadia
   11. Molly Hair
   12. Sagar Batra
   13. Robert Markus
   14. Declan Brady
   15. Andrew R Bottrill
   16. Sue Vaughan
   17. Cyrille Y Botté
   18. Karine G Le Roch
   19. Anthony A Holder
   20. Eelco Tromer
   21. Rita Tewari

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In Plasmodium male gametocytes, rapid nuclear division occurs with an intact nuclear envelope, requiring precise coordination between nuclear and cytoplasmic events to ensure proper packaging of each nucleus into a developing gamete. This valuable study characterizes two proteins involved in the formation of Plasmodium berghei male gametes. By integrating live-cell imaging, ultrastructural expansion microscopy, and proteomics, this study convincingly identifies SUN1 and its interaction partner ALLAN as crucial nuclear envelope components in male gametogenesis. A role for SUN1 in membrane dynamics and lipid metabolism is less well supported. The results are of interest for general cell biologists working on unusual mitosis pathways.

     [Editors' note: this paper was reviewed by Review Commons.]

   Reviewed by eLife, Review Commons

2. The influence of the pre-membrane and envelope proteins on structure, pathogenicity and tropism of tick-borne encephalitis virus

   This article has 19 authors:

   1. Ebba Rosendal
   2. Kyrylo Bisikalo
   3. Stefanie M.A. Willekens
   4. Marie Lindgren
   5. Jiří Holoubek
   6. Pavel Svoboda
   7. Amanda Lappalainen
   8. Ebba Könighofer
   9. Ekaterina Mirgorodskaya
   10. Rickard Nordén
   11. Federico Morini
   12. William Rosenbaum
   13. Daniel Růžek
   14. Ulf Ahlgren
   15. Maria Anastasina
   16. Andres Merits
   17. Sarah J Butcher
   18. Emma Nilsson
   19. Anna K Överby

   Reviewed by Review Commons

3. Med12 cooperates with multiple differentiation signals to facilitate efficient lineage transitions in embryonic stem cells

   This article has 2 authors:

   1. Max Fernkorn
   2. Christian Schröter

   Reviewed by Review Commons

4. Piezo1 balances membrane tension and cortical contractility to stabilize intercellular junctions and maintain epithelial barrier integrity

   This article has 8 authors:

   1. Ahsan Javed
   2. Aki Stubb
   3. Clémentine Villeneuve
   4. Franziska Peters
   5. Matthias Rübsam
   6. Carien M. Niessen
   7. Leah C. Biggs
   8. Sara A. Wickström

   Reviewed by Review Commons

5. Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation

   This article has 3 authors:

   1. Liuqun Zhao
   2. Tanel Punga
   3. Suparna Sanyal

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study investigates the molecular mechanisms by which the p53 isoforms Δ133p53α and Δ160p53α exert dominant-negative effects on full-length p53 (FLp53). Through a combination of chromatin immunoprecipitation, transcriptional reporter assays, subcellular localization analyses, and protein aggregation experiments, the authors provide solid evidence that these N-terminally truncated isoforms promote co-aggregation with FLp53, disrupting its transcriptional activity and cellular distribution. The revised manuscript successfully addresses prior reviewer concerns, and the findings are well supported by the experimental data.

     [Editors' note: this paper was reviewed by Review Commons.]

   Reviewed by eLife, Review Commons

6. Regional heterogeneities of oligodendrocytes underlie biased Ranvier node spacing along single axons in sound localization circuit

   This article has 5 authors:

   1. Ryo Egawa
   2. Kota Hiraga
   3. Ryosuke Matsui
   4. Dai Watanabe
   5. Hiroshi Kuba

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study uses the delay line axon model in the chick brainstem auditory circuit to examine the interactions between oligodendrocytes and axons in the formation of internodal distances. This is a significant and actively studied topic, and the authors have used this preparation to support the hypothesis that regional heterogeneity in oligodendrocytes underlies the observed variation in internodal length. In a solid series of experiments, the authors have used enhanced tetanus neurotoxin light chains, a genetically encoded silencing tool, to inhibit vesicular release from axons and support the hypothesis that regional heterogeneity among oligodendrocytes may underlie the biased nodal spacing pattern in the sound localization circuit.

     [Editors' note: this paper was reviewed by Review Commons.]

   Reviewed by eLife, Review Commons

7. Quantification of Cyclin-CDK dissociation constants in living cells using fluorescence cross-correlation spectroscopy with green and near-infrared fluorescent proteins

   This article has 7 authors:

   1. Aika Toyama
   2. Yuhei Goto
   3. Yuhei Yamauchi
   4. Hironori Sugiyama
   5. Yohei Kondo
   6. Atsushi Mochizuki
   7. Kazuhiro Aoki

   Reviewed by Review Commons

8. A transcription factor toggle switch determines differentiated epidermal cell identities in Hydra

   This article has 6 authors:

   1. Jaroslav Ferenc
   2. Marylène Bonvin
   3. Panagiotis Papasaikas
   4. Jacqueline Ferralli
   5. Clara Nuninger
   6. Charisios D. Tsiairis

   Reviewed by Review Commons

9. The SUMO activating enzyme subunit, SAE2, contributes SUMO protein bias for mitotic fidelity

   This article has 8 authors:

   1. Alexandra K. Walker
   2. Alexander J. Lanz
   3. Mohammed Jamshad
   4. Alexander J. Garvin
   5. Peter Wotherspoon
   6. Benjamin F. Cooper
   7. Timothy J. Knowles
   8. Joanna R. Morris

   Reviewed by Review Commons

10. Embryological cellular origins and hypoxia-mediated mechanisms in PIK3CA -Driven refractory vascular malformations

    This article has 13 authors:

    1. Sota Torii
    2. Keiki Nagaharu
    3. Nanako Nakanishi
    4. Hidehito Usui
    5. Yumiko Hori
    6. Katsutoshi Hirose
    7. Satoru Toyosawa
    8. Eiichi Morii
    9. Mitsunaga Narushima
    10. Yoshiaki Kubota
    11. Osamu Nakagawa
    12. Kyoko Imanaka-Yoshida
    13. Kazuaki Maruyama

    Reviewed by Review Commons