Review Commons

Latest preprint reviews

1. LGL-1 and the RhoGAP protein PAC-1 redundantly polarize the C. elegans embryonic epidermis

   This article has 9 authors:

   1. Olga D. Jarosińska
   2. Amalia Riga
   3. Hala Zahreddine Fahs
   4. Joren M. Woeltjes
   5. Ruben Schmidt
   6. Fathima S. Refai
   7. Suma Gopinadhan
   8. Kristin C. Gunsalus
   9. Mike Boxem

   Reviewed by Review Commons

2. HIV-1 envelope glycoprotein modulates CXCR4 clustering and dynamics on the T cell membrane

   This article has 16 authors:

   1. Adriana Quijada-Freire
   2. César A Santiago
   3. Eva M García-Cuesta
   4. Blanca Soler Palacios
   5. Rosa Ayala-Bueno
   6. Sofia R Gardeta
   7. Enara San Sebastian
   8. Eva Armendariz-Burgoa
   9. Maria Carmen Puertas
   10. Ricardo Villares
   11. Urtzi Garaigorta
   12. Luis Ignacio González-Granado
   13. Jose Miguel Rodriguez Frade
   14. Jakub Chojnacki
   15. Javier Martinez-Picado
   16. Mario Mellado

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable insights into how HIV-1 Env modulates the nanoscale organization and dynamics of the CXCR4 co-receptor on T cells, using quantitative imaging and functional approaches, the authors present convincing evidence that gp120 engagement promotes CD4-dependent clustering and altered mobility of CXCR4, distinct from the effects of the natural ligand CXCL12. Some concerns were raised regarding the interpretation of the single-particle tracking analyses, and additional clarification or analysis may help strengthen the conclusions. The physiological relevance of the findings could be further enhanced by validation with infectious virus and by more clearly integrating the CXCR4R334X mutant observations into the central mechanistic narrative. The work will be of interest to researchers studying HIV entry and membrane receptor organization.

     [Editors' note: this paper was reviewed by Review Commons.]

   Reviewed by eLife, Review Commons

3. From Noise to Models to Numbers: Evaluating Negative Binomial Models and Parameter Estimations in Single-Cell RNA-seq

   This article has 4 authors:

   1. Yiling Wang
   2. Zhanpeng Shu
   3. Zhixing Cao
   4. Ramon Grima

   Reviewed by Review Commons

4. Cell type specific allometry controls sex-differences in Drosophila organ size

   This article has 9 authors:

   1. Soumitra Pal
   2. Jerome Avellaneda
   3. Celena M Cherian
   4. Puja Biswas
   5. Georg Vogler
   6. Elizabeth J Rideout
   7. Frank Schnorrer
   8. Teresa M Przytycka
   9. Brian Oliver

   Reviewed by Review Commons

5. Orphan nuclear receptors recruit TRIM28 to promote telomeric H3K9me3 for the alternative lengthening of telomeres pathway

   This article has 5 authors:

   1. Chia-Tsen Tsai
   2. Venus Marie Gaela
   3. Hsuan-Yu Hsia
   4. Yu-Chen Huang
   5. Liuh-Yow Chen

   Reviewed by Review Commons

6. The Rho effector ARHGAP18 coordinates a Hippo pathway feedback loop through YAP and Merlin to regulate the cytoskeleton and epithelial cell polarity

   This article has 7 authors:

   1. Emma C. Murray
   2. Gillian M. Hodge
   3. Khanh Pham
   4. Leighton S. Lee
   5. Cameron A.R. Mitchell
   6. Yongho Bae
   7. Andrew T. Lombardo

   Reviewed by Review Commons

7. Centrosome Loss in Embryonic Development Disrupts Axonal Pathfinding and Muscle Integrity

   This article has 5 authors:

   1. Beatriz González
   2. Júlia Sellés-Altés
   3. Jèrica Pla-Parron
   4. Judith Castro-Ribera
   5. Sofia J. Araújo

   Reviewed by Review Commons

8. Unravelling the progression of the zebrafish primary body axis with reconstructed spatiotemporal transcriptomics

   This article has 13 authors:

   1. Yang Dong
   2. Tao Cheng
   3. Xiang Liu
   4. Xin-Xin Fu
   5. Yang Hu
   6. Xian-Fa Yang
   7. Ling-En Yang
   8. Hao-Ran Li
   9. Zhi-Wen Bian
   10. Naihe Jing
   11. Jie Liao
   12. Xiaohui Fan
   13. Peng-Fei Xu

   Reviewed by Review Commons

9. Hic2 fast-tracks iPS cell generation by suppressing KLF4-dependent epidermal detour

   This article has 12 authors:

   1. Meryam Beniazza
   2. Masahito Yoshihara
   3. Daniel F Kaemena
   4. James Ashmore
   5. Suling Zhao
   6. Michael O’Dwyer
   7. Emil Andersson
   8. Victor Olariu
   9. Shintaro Katayama
   10. Abdenour Soufi
   11. Kosuke Yusa
   12. Keisuke Kaji

   Reviewed by Review Commons

10. Opposing CTCF and GATA4 activities set the pace of chromatin topology remodeling during cardiomyogenesis

    This article has 11 authors:

    1. Silvia Becca
    2. Sara Bianchi
    3. Elisa M. Hahn
    4. Kirsten E. Snijders
    5. Lukasz Truszkowski
    6. Anna Krepelova
    7. Francesco Neri
    8. Davide Cacchiarelli
    9. Sasha Mendjan
    10. Elisa Balmas
    11. Alessandro Bertero

    Reviewed by Review Commons