Review Commons

Latest preprint reviews

1. Microbiota impact Drosophila ageing via Acetobacter, Tachykinin, and TkR99D

   This article has 7 authors:

   1. Diana Marcu
   2. David R Sannino
   3. Anthony J Dornan
   4. Rita Ibrahim
   5. Atharv Kapoor
   6. Miriam Wood
   7. Adam J Dobson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study demonstrates that in Drosophila melanogaster, tachykinin (Tk) expression is regulated by the microbiota. The authors present convincing evidence that axenic flies raised with no microbiota are longer-lived than conventionally reared animals, and that Tk expression and Tk receptors in the nervous system are required for this effect. They further test individual bacterial strains for their role in these effects and connect the effect to loss of lipid stores and suggest that FOXO may be involved in the phenotype, results that are of interest to the fields of environmental perception, host microbiome interactions, and geroscience.

     [Editors' note: this paper was reviewed by Review Commons.]

   Reviewed by eLife, Review Commons

2. Chronic replication stress-mediated genomic instability disrupts placenta development in mice

   This article has 4 authors:

   1. Mumingjiang Munisha
   2. Rui Huang
   3. Jordan Khan
   4. John C. Schimenti

   Reviewed by Review Commons

3. miR-184 modulates dilp8 to control developmental timing during normal growth conditions and in response to developmental perturbations

   This article has 4 authors:

   1. Jervis Fernandes
   2. Muhammed Naseem
   3. Ayisha Marwa MP
   4. Jishy Varghese

   Reviewed by Review Commons

4. The Ketogenic Diet Metabolite β-Hydroxybutyrate Promotes Mitochondrial Elongation via Deacetylation and Improves Autism-like Behavior in Zebrafish

   This article has 8 authors:

   1. Golam M. Uddin
   2. Rachel Lacroix
   3. Mashiat Zaman
   4. Iman Al Khatib
   5. Amit Jaiswal
   6. Jong M. Rho
   7. Deborah M. Kurrasch
   8. Timothy E. Shutt

   Reviewed by Review Commons

5. When mitochondria fall apart: Unbalanced mitochondrial segregation triggers loss of mtDNA in the absence of mitochondrial fusion

   This article has 8 authors:

   1. Lisa Dengler
   2. Francesco Padovani
   3. Bianca Lemke
   4. Rebecca Brugger
   5. Benedikt Westermann
   6. Boris Maček
   7. Kurt M. Schmoller
   8. Jennifer C. Ewald

   Reviewed by Review Commons

6. Interferon-β induction heterogeneity during KSHV infection is correlated to levels and activation of the transcription factors ATF2 and RelA, and not IRF3

   This article has 2 authors:

   1. Machika Kaku
   2. Marta Maria Gaglia

   Reviewed by Review Commons

7. Global molecular landscape of early MASLD progression in human obesity

   This article has 21 authors:

   1. Qing Zhao
   2. William De Nardo
   3. Ruoyu Wang
   4. Yi Zhong
   5. Umur Keles
   6. Gabriele Sakalauskaite
   7. Li Na Zhao
   8. Huiyi Tay
   9. Sonia Youhanna
   10. Mengchao Yan
   11. Ye Xie
   12. Youngrae Kim
   13. Sungdong Lee
   14. Rachel Liyu Lim
   15. Guoshou Teo
   16. Pradeep Narayanaswamy
   17. Paul R Burton
   18. Volker M Lauschke
   19. Hyungwon Choi
   20. Matthew J Watt
   21. Philipp Kaldis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors provide a useful resource and approach to identify early-stage biomarkers of MASLD progression, notably when no other apparent symptoms have arisen. The strength of evidence to support new MASLD signatures is solid as the work combines metabolomic and transcriptomic measures in blood and liver biopsies.

     [Editors' note: this paper was reviewed by Review Commons.]

   Reviewed by eLife, Review Commons

8. Assessing target genes for homing suppression gene drive

   This article has 8 authors:

   1. Xuejiao Xu
   2. Jialing Fang
   3. Jingheng Chen
   4. Jie Yang
   5. Xiaozhen Yang
   6. Shibo Hou
   7. Weitang Sun
   8. Jackson Champer

   Reviewed by Review Commons

9. E4BP4 Safeguards Brown Fat Mitochondria from Obesity-Induced Fragmentation via Ceramide Repression

   This article has 17 authors:

   1. Fernando Valdivieso-Rivera
   2. Vanessa O. Furino
   3. Carlos E. Leher
   4. Ariane M. Zanesco
   5. Monara Kaélle Cruz
   6. Flavia C. Gan
   7. Adriana Leandra Santoro
   8. Lara Regina-Ferreira
   9. Giovanna Leite Santos
   10. Tiago Gonçalves
   11. Luiz Osório Leiria
   12. Pedro M. Moraes-Vieira
   13. Roger Frigério Castilho
   14. Shingo Kajimura
   15. Marcelo A. Mori
   16. Licio A. Velloso
   17. Carlos H. Sponton

   Reviewed by Review Commons

10. Provision of Preferred Nutrients to Macrophages Enables Salmonella to Replicate Intracellularly Without Relying on Type III Secretion Systems

    This article has 4 authors:

    1. Francisco-Javier Garcia-Rodriguez
    2. Camila Valenzuela
    3. Joaquin Bernal-Bayard
    4. Pedro Escoll

    Reviewed by Review Commons