preLights

Latest preprint reviews

1. Segmentation of the Zebrafish Brain Vasculature from Light Sheet Fluorescence Microscopy Datasets

   This article has 4 authors:

   1. Elisabeth C. Kugler
   2. Andrik Rampun
   3. Timothy J.A. Chico
   4. Paul A. Armitage

   Reviewed by preLights

2. OptiJ: Open-source optical projection tomography of large organ samples

   This article has 22 authors:

   1. Pedro P. Vallejo Ramirez
   2. Joseph Zammit
   3. Oliver Vanderpoorten
   4. Fergus Riche
   5. Francois-Xavier Blé
   6. Xiao-Hong Zhou
   7. Bogdan Spiridon
   8. Christopher Valentine
   9. Simeon E. Spasov
   10. Pelumi W. Oluwasanya
   11. Gemma Goodfellow
   12. Marcus J. Fantham
   13. Omid Siddiqui
   14. Farah Alimagham
   15. Miranda Robbins
   16. Andrew Stretton
   17. Dimitrios Simatos
   18. Oliver Hadeler
   19. Eric J. Rees
   20. Florian Ströhl
   21. Romain F. Laine
   22. Clemens F. Kaminski

   Reviewed by preLights

3. Mutational signatures are jointly shaped by DNA damage and repair

   This article has 11 authors:

   1. Nadezda V. Volkova
   2. Bettina Meier
   3. Víctor González-Huici
   4. Simone Bertolini
   5. Santiago Gonzalez
   6. Harald Vöhringer
   7. Federico Abascal
   8. Iñigo Martincorena
   9. Peter J. Campbell
   10. Anton Gartner
   11. Moritz Gerstung

   Reviewed by preLights

4. Dectin-1 limits central nervous system autoimmunity through a non-canonical pathway

   This article has 9 authors:

   1. M. Elizabeth Deerhake
   2. Keiko Danzaki
   3. Makoto Inoue
   4. Emre D. Cardakli
   5. Toshiaki Nonaka
   6. Nupur Aggarwal
   7. William E. Barclay
   8. Ru Rong Ji
   9. Mari L. Shinohara

   Reviewed by preLights

5. STING mediates immune responses in the closest living relatives of animals

   This article has 6 authors:

   1. Arielle Woznica
   2. Ashwani Kumar
   3. Carolyn R Sturge
   4. Chao Xing
   5. Nicole King
   6. Julie K Pfeiffer

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The authors addressed the role of a STING ortholog in antimicrobial defense of choanoflagellates. The analysis of the response of the choanoflagellate Monosiga brevicollis to a variety of bacterial species revealed that exposure of M. brevicollis to Pseudomonas aeruginosa conditioned medium results in choanoflagellate death and the authors found that this is dependent on the newly discovered ortholog of STING. Characterization reveals that the STING response can be induced by 2'3' cGAMP, which parallels the activation of STING in diverse species. In addition, the finding that cyclic dinucleotide treatment induces autophagy also has parallels with the effector pathways observed in other organisms. There are a number of strengths as outlined by the Reviewers. First, the development of a Choanaoflagellate model system to study innate immunity, second with the development of genetics for M. brevicollis, third, the demonstration of a functional STING system in one of the closest relatives to animals and fourth, that cell death occurs in response to cyclic dinucleotides.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife, preLights

6. Multi-scale spatial heterogeneity enhances particle clearance in airway ciliary arrays

   This article has 6 authors:

   1. Guillermina R. Ramirez-San Juan
   2. Arnold J. T. M. Mathijssen
   3. Mu He
   4. Lily Jan
   5. Wallace Marshall
   6. Manu Prakash

   Reviewed by preLights

7. High survival following bleaching highlights the resilience of a highly disturbed region of the Great Barrier Reef

   This article has 4 authors:

   1. Cathie A Page
   2. Christine Giuliano
   3. Line K Bay
   4. Carly J Randall

   Reviewed by preLights

8. A spatially resolved single cell atlas of human gastrulation

   This article has 6 authors:

   1. Richard C.V. Tyser
   2. Elmir Mahammadov
   3. Shota Nakanoh
   4. Ludovic Vallier
   5. Antonio Scialdone
   6. Shankar Srinivas

   Reviewed by preLights

9. Antlions are sensitive to subnanometer amplitude vibrations carried by sand substrates

   This article has 4 authors:

   1. Vanessa Martinez
   2. Elise Nowbahari
   3. David Sillam-Dussès
   4. Vincent Lorent

   Reviewed by preLights

10. Utah-Stanford Ventilator (Vent4US): Developing a rapidly scalable ventilator for COVID-19 patients with ARDS

    This article has 14 authors:

    1. Hongquan Li
    2. Ethan Li
    3. Deepak Krishnamurthy
    4. Patrick Kolbay
    5. Beca Chacin
    6. Soeren Hoehne
    7. Jim Cybulski
    8. Lara Brewer
    9. Tomasz Petelenz
    10. Joseph Orr
    11. Derek Sakata
    12. Thomas Clardy
    13. Kai Kuck
    14. Manu Prakash

    Reviewed by ScreenIT, preLights