Latest preprint reviews

1. PUFFFIN: A novel, ultra-bright, customisable, single-plasmid system for labelling cell neighbourhoods

   This article has 4 authors:

   1. Tamina Lebek
   2. Mattias Malaguti
   3. Alistair Elfick
   4. Sally Lowell

   Reviewed by Review Commons, preLights

2. Glutamate helps unmask the differences in driving forces for phase separation versus clustering of FET family proteins in sub-saturated solutions

   This article has 10 authors:

   1. Mrityunjoy Kar
   2. Laura T. Vogel
   3. Gaurav Chauhan
   4. Hannes Ausserwöger
   5. Timothy J. Welsh
   6. Anjana R. Kamath
   7. Tuomas P. J. Knowles
   8. Anthony A. Hyman
   9. Claus A. M. Seidel
   10. Rohit V. Pappu

   Reviewed by preLights

3. The genome of the colonial hydroid Hydractinia reveals that their stem cells use a toolkit of evolutionarily shared genes with all animals

   This article has 29 authors:

   1. Christine E. Schnitzler
   2. E. Sally Chang
   3. Justin Waletich
   4. Gonzalo Quiroga-Artigas
   5. Wai Yee Wong
   6. Anh-Dao Nguyen
   7. Sofia N. Barreira
   8. Liam B. Doonan
   9. Paul Gonzalez
   10. Sergey Koren
   11. James M. Gahan
   12. Steven M. Sanders
   13. Brian Bradshaw
   14. Timothy Q. DuBuc
   15. Febrimarsa
   16. Danielle de Jong
   17. Eric P. Nawrocki
   18. Alexandra Larson
   19. Samantha Klasfeld
   20. Sebastian G. Gornik
   21. R. Travis Moreland
   22. Tyra G. Wolfsberg
   23. Adam M. Phillippy
   24. James C. Mullikin
   25. Oleg Simakov
   26. Paulyn Cartwright
   27. Matthew Nicotra
   28. Uri Frank
   29. Andreas D. Baxevanis

   Reviewed by preLights

4. TLR2 regulates hair follicle cycle and regeneration via BMP signaling

   This article has 10 authors:

   1. Luyang Xiong
   2. Irina Zhevlakova
   3. Xiaoxia Z West
   4. Detao Gao
   5. Rakhilya Murtazina
   6. Anthony Horak
   7. J Mark Brown
   8. Iuliia Molokotina
   9. Eugene A Podrez
   10. Tatiana V Byzova

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Toll like receptor 2 (TLR2) signaling has traditionally been viewed a surface protein that induces innate immune responses and improves acquired immunity. Here, the authors suggest a different role for TLR2 in the hair cycle. By using a Cre reporter that is largely, but not solely active in hair follicle stem cells, the authors conditionally delete Tlr2 in mice and report that BMP signaling is sustained and hair cycle entry is delayed. Delving further, the authors identify CEP (2-ω-carboxyethyl pyrrole) as an endogenous ligand of TLR2 in hair follicle stem cell regulation. Although a role for TLR2 signaling in hair follicle stem cells is potentially novel and important, the reviewers remain in consensus that evidence presented in two significant areas continues to be incomplete: 1) where TLR2 and CEP are expressed and how specific is their expression to the hair follicle stem cells; 2) whether as the authors suggest, TLR2 functions by regulating BMP signaling in the stem cell niche of the hair follicle.

   Reviewed by eLife, preLights

5. Optical Control of G-Actin with a Photoswitchable Latrunculin

   This article has 13 authors:

   1. Nynke A. Vepřek
   2. Madeline H. Cooper
   3. Laura Laprell
   4. Emily Jie-Ning Yang
   5. Sander Folkerts
   6. Ruiyang Bao
   7. Malgorzata Boczkowska
   8. Nicholas J. Palmer
   9. Roberto Dominguez
   10. Thomas G. Oertner
   11. Liza A. Pon
   12. J. Bradley Zuchero
   13. Dirk H. Trauner

   Reviewed by preLights

6. Hypoxia blunts angiogenic signaling and upregulates the antioxidant system in elephant seal endothelial cells

   This article has 6 authors:

   1. Kaitlin N Allen
   2. Julia María Torres-Velarde
   3. Juan Manuel Vazquez
   4. Diana D Moreno-Santillan
   5. Peter H Sudmant
   6. José Pablo Vázquez-Medina

   Reviewed by preLights

7. Mechano-dependent sorbitol accumulation supports biomolecular condensate

   This article has 16 authors:

   1. Stephanie Torrino
   2. William M Oldham
   3. Andrés R Tejedor
   4. Ignacio S. Burgos
   5. Nesrine Rachedi
   6. Kéren Fraissard
   7. Caroline Chauvet
   8. Chaima Sbai
   9. Brendan P. O’Hara
   10. Sophie Abélanet
   11. Frederic Brau
   12. Stephan Clavel
   13. Rosana Collepardo-Guevara
   14. Jorge R. Espinosa
   15. Issam Ben-Sahra
   16. Thomas Bertero

   Reviewed by preLights

8. CRISPR-dependent Base Editing Screens Identify Separation of Function Mutants of RADX with Altered RAD51 Regulatory Activity

   This article has 7 authors:

   1. Madison B. Adolph
   2. Atharv S. Garje
   3. Swati Balakrishnan
   4. Florian Morati
   5. Mauro Modesti
   6. Walter J. Chazin
   7. David Cortez

   Reviewed by preLights

9. Proteasome condensate formation is driven by multivalent interactions with shuttle factors and K48-linked ubiquitin chains

   This article has 4 authors:

   1. Kenrick A. Waite
   2. Gabrielle Vontz
   3. Stella Y. Lee
   4. Jeroen Roelofs

   Reviewed by preLights

10. A Phosphoproteomics Data Resource for Systems-level Modeling of Kinase Signaling Networks

    This article has 10 authors:

    1. Song Feng
    2. James A. Sanford
    3. Thomas Weber
    4. Chelsea M. Hutchinson-Bunch
    5. Panshak P. Dakup
    6. Vanessa L. Paurus
    7. Kwame Attah
    8. Herbert M. Sauro
    9. Wei-Jun Qian
    10. H. Steven Wiley

    Reviewed by preLights