eLife

Latest preprint reviews

1. Septin 7 interacts with Numb to preserve sarcomere structural organization and muscle contractile function

   This article has 12 authors:

   1. Rita De Gasperi
   2. Laszlo Csernoch
   3. Beatrix Dienes
   4. Monika Gonczi
   5. Jayanta K Chakrabarty
   6. Shahar Goeta
   7. Abdurrahman Aslan
   8. Carlos A Toro
   9. David Karasik
   10. Lewis M Brown
   11. Marco Brotto
   12. Christopher P Cardozo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This convincing study demonstrates a potentially important role for the factor Numb in skeletal muscle excitation-contraction coupling, since a Numb knockout reduced contractile force. The authors thus demonstrate a novel role for Numb in calcium release in skeletal muscle.

   Reviewed by eLife

2. Systematic Analysis of Network-driven Adaptive Resistance to CDK4/6 and Estrogen Receptor Inhibition using Meta-Dynamic Network Modelling

   This article has 3 authors:

   1. Anthony Hart
   2. Sung-Young Shin
   3. Lan K Nguyen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript presents a useful computational framework for systematically characterising how heterogeneity in initial conditions or biophysical parameters shapes the dynamic behaviour of protein signalling networks, with potential relevance to understanding adaptive drug resistance. While the approach represents a significant methodological contribution, the extent to which its conclusions are biologically informative remains debated, as the model is only qualitatively compared with experimental data and lacks quantitative validation. As a result, the strength of evidence supporting the mechanistic claims is viewed as incomplete.

   Reviewed by eLife

3. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2301.00759

4. Avoiding false discoveries in single-cell RNA-seq by revisiting the first Alzheimer’s disease dataset

   This article has 3 authors:

   1. Alan E Murphy
   2. Nurun Fancy
   3. Nathan Skene

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper reports a useful finding on the impact of choices of quality control and differential analysis methods on the discovery of disease-associated gene expression signatures. The study provides a solid comparison of the data process by re-analysis of a large-scale snRNA-seq dataset for Alzheimer's Disease. This paper would be of interest to the community as to rigorous analyses for large-scale single cell datasets.

   Reviewed by eLife

5. Dynamic landscape of the intracellular termini of acid-sensing ion channel 1a

   This article has 4 authors:

   1. Megan M Cullinan
   2. Robert C Klipp
   3. Abigail Camenisch
   4. John R Bankston

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study illuminates molecular movements of acid-sensing ion channels by combining advanced chemical biology and biophysical techniques. The evidence for the main claim, lack of interaction of molecular termini, is compelling and challenges prior models. This work is expected to pique interest in the ion channel signaling field, providing a fresh perspective.

   Reviewed by eLife

6. Deciphering the chemical language of inbred and wild mouse conspecific scents

   This article has 9 authors:

   1. Maximilian Nagel
   2. Marco Niestroj
   3. Rohini Bansal
   4. David Fleck
   5. Angelika Lampert
   6. Romana Stopkova
   7. Pavel Stopka
   8. Yoram Ben-Shaul
   9. Marc Spehr

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This carefully executed study provides a comparison of the chemical composition of mouse urine across strain and sex with the responses of vomeronasal sensory neurons, which are responsible for detecting chemical social cues. While the authors did not examine all molecular classes found in mouse urine or directly test whether the urinary volatile chemicals that vary with sex and strain are effective vomeronasal neuron ligands, solid data are provided that will be of significant interest to those studying chemical communication in rodents. This work should provide a valuable foundation for future research that will determine which molecules drive sex- and strain-specific vomeronasal responses.

   Reviewed by eLife

7. Precise spatial tuning of visually driven alpha oscillations in human visual cortex

   This article has 13 authors:

   1. Kenichi Yuasa
   2. Iris IA Groen
   3. Giovanni Piantoni
   4. Stephanie Montenegro
   5. Adeen Flinker
   6. Sasha Devore
   7. Orrin Devinsky
   8. Werner Doyle
   9. Patricia Dugan
   10. Daniel Friedman
   11. Nick F Ramsey
   12. Natalia Petridou
   13. Jonathan Winawer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This intracranial EEG study presents important and convincing neural evidence supporting the high spatial specificity (receptive field) of visually driven alpha-band oscillation in human brains and its potential role in exogenous cuing attention. The work challenges the predominant view about the role of alpha-band oscillation in visual attention and advocates that stimulus-driven alpha suppression is precisely tuned and might contribute to exogenous spatial attention.

   Reviewed by eLife

8. Modeled grid cells aligned by a flexible attractor

   This article has 3 authors:

   1. Sabrina Benas
   2. Ximena Fernandez
   3. Emilio Kropff

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this valuable study, the authors use a computational model to investigate how recurrent connections influence the firing patterns of grid cells, which are thought to play a role in encoding an animal's position in space. The work suggests that a one-dimensional network architecture may be sufficient to generate the hexagonal firing patterns of grid cells, a possible alternative to attractor models based on recurrent connectivity between grid cells. However, the support for this proposal was incomplete, as some conclusions for how well the model dynamics are necessary to generate features of grid cell organization were not well supported.

   Reviewed by eLife

9. Postsynaptic mitochondria are positioned to support functional diversity of dendritic spines

   This article has 4 authors:

   1. Connon I Thomas
   2. Melissa A Ryan
   3. Naomi Kamasawa
   4. Benjamin Scholl

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study reports valuable findings on the correlation between the positions of dendritic mitochondria and the orientation preference of calcium responses of individual spines. The conclusion about the biased localization of dendritic mitochondria near functional diverse spines is informative to understand the functions of dendritic mitochondria. The experimental evidence supporting the conclusion is compelling.

   Reviewed by eLife

10. Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

    This article has 131 authors:

    1. Hideo Hagihara
    2. Hirotaka Shoji
    3. Satoko Hattori
    4. Giovanni Sala
    5. Yoshihiro Takamiya
    6. Mika Tanaka
    7. Masafumi Ihara
    8. Mihiro Shibutani
    9. Izuho Hatada
    10. Kei Hori
    11. Mikio Hoshino
    12. Akito Nakao
    13. Yasuo Mori
    14. Shigeo Okabe
    15. Masayuki Matsushita
    16. Anja Urbach
    17. Yuta Katayama
    18. Akinobu Matsumoto
    19. Keiichi I Nakayama
    20. Shota Katori
    21. Takuya Sato
    22. Takuji Iwasato
    23. Haruko Nakamura
    24. Yoshio Goshima
    25. Matthieu Raveau
    26. Tetsuya Tatsukawa
    27. Kazuhiro Yamakawa
    28. Noriko Takahashi
    29. Haruo Kasai
    30. Johji Inazawa
    31. Ikuo Nobuhisa
    32. Tetsushi Kagawa
    33. Tetsuya Taga
    34. Mohamed Darwish
    35. Hirofumi Nishizono
    36. Keizo Takao
    37. Kiran Sapkota
    38. Kazutoshi Nakazawa
    39. Tsuyoshi Takagi
    40. Haruki Fujisawa
    41. Yoshihisa Sugimura
    42. Kyosuke Yamanishi
    43. Lakshmi Rajagopal
    44. Nanette Deneen Hannah
    45. Herbert Y Meltzer
    46. Tohru Yamamoto
    47. Shuji Wakatsuki
    48. Toshiyuki Araki
    49. Katsuhiko Tabuchi
    50. Tadahiro Numakawa
    51. Hiroshi Kunugi
    52. Freesia L Huang
    53. Atsuko Hayata-Takano
    54. Hitoshi Hashimoto
    55. Kota Tamada
    56. Toru Takumi
    57. Takaoki Kasahara
    58. Tadafumi Kato
    59. Isabella A Graef
    60. Gerald R Crabtree
    61. Nozomi Asaoka
    62. Hikari Hatakama
    63. Shuji Kaneko
    64. Takao Kohno
    65. Mitsuharu Hattori
    66. Yoshio Hoshiba
    67. Ryuhei Miyake
    68. Kisho Obi-Nagata
    69. Akiko Hayashi-Takagi
    70. Léa J Becker
    71. Ipek Yalcin
    72. Yoko Hagino
    73. Hiroko Kotajima-Murakami
    74. Yuki Moriya
    75. Kazutaka Ikeda
    76. Hyopil Kim
    77. Bong-Kiun Kaang
    78. Hikari Otabi
    79. Yuta Yoshida
    80. Atsushi Toyoda
    81. Noboru H Komiyama
    82. Seth GN Grant
    83. Michiru Ida-Eto
    84. Masaaki Narita
    85. Ken-ichi Matsumoto
    86. Emiko Okuda-Ashitaka
    87. Iori Ohmori
    88. Tadayuki Shimada
    89. Kanato Yamagata
    90. Hiroshi Ageta
    91. Kunihiro Tsuchida
    92. Kaoru Inokuchi
    93. Takayuki Sassa
    94. Akio Kihara
    95. Motoaki Fukasawa
    96. Nobuteru Usuda
    97. Tayo Katano
    98. Teruyuki Tanaka
    99. Yoshihiro Yoshihara
    100. Michihiro Igarashi
    101. Takashi Hayashi
    102. Kaori Ishikawa
    103. Satoshi Yamamoto
    104. Naoya Nishimura
    105. Kazuto Nakada
    106. Shinji Hirotsune
    107. Kiyoshi Egawa
    108. Kazuma Higashisaka
    109. Yasuo Tsutsumi
    110. Shoko Nishihara
    111. Noriyuki Sugo
    112. Takeshi Yagi
    113. Naoto Ueno
    114. Tomomi Yamamoto
    115. Yoshihiro Kubo
    116. Rie Ohashi
    117. Nobuyuki Shiina
    118. Kimiko Shimizu
    119. Sayaka Higo-Yamamoto
    120. Katsutaka Oishi
    121. Hisashi Mori
    122. Tamio Furuse
    123. Masaru Tamura
    124. Hisashi Shirakawa
    125. Daiki X Sato
    126. Yukiko U Inoue
    127. Takayoshi Inoue
    128. Yuriko Komine
    129. Tetsuo Yamamori
    130. Kenji Sakimura
    131. Tsuyoshi Miyakawa

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The manuscript offers useful descriptive insights into the potential influence of whole-brain lactate and pH levels on the manifestation of behavioral phenotypes seen in diverse animal models of neuropsychiatric disorders. However, reviewers have raised concerns about the potential loss of specificity in capturing regional and cell-type-specific effects when relying solely on whole-brain analysis methods. While the evidence supporting the conclusions is largely solid, the robustness of these conclusions could be enhanced by the inclusion of additional data and further analysis.

    Reviewed by eLife