Arcadia Science

Latest preprint reviews

1. Evolutionary remodeling of non-canonical ORF translation in mammals

   This article has 7 authors:

   1. Yue Chang
   2. Tianyu Lei
   3. Feng Zhou
   4. Jiawen Jiang
   5. Yu Huang
   6. Ziyang Zhu
   7. Hong Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a large, systematically curated catalog of non-canonical open reading frames (ncORFs) in human and mouse through the reanalysis of nearly 400 Ribo-seq datasets using a standardized pipeline; the resulting atlas consolidates ncORF annotations across tissues and provides a valuable resource for investigating non-canonical translation and ORF emergence. The main conclusions are supported by consistent data processing and multiple computational measures of translation and conservation. While the pipeline is transparent and technically robust, some analytical criteria and dataset limitations could be described more explicitly, and several downstream conclusions would benefit from more cautious interpretation, some evolutionary inferences are primarily correlative; dataset heterogeneity, uneven tissue representation, and limited experimental validation also constrain the strength of a subset of the findings. Overall, the evidence is solid, and the resource is likely to be broadly beneficial to the community.

   Reviewed by eLife, Arcadia Science

2. Fluorescence Lifetime Unmixing: A New Workflow for FLIM Live-Cell Imaging

   This article has 9 authors:

   1. Cornelia Wetzker
   2. Marcelo Leomil Zoccoler
   3. Svetlana Iarovenko
   4. Chukwuebuka William Okafornta
   5. Anja Nobst
   6. Hella Hartmann
   7. Thomas Müller-Reichert
   8. Robert Haase
   9. Gunar Fabig

   Reviewed by Arcadia Science

3. Exopolysaccharides of Lactobacillus crispatus mediate key balancing interactions with the vaginal mucosa

   This article has 20 authors:

   1. Vanessa Croatti
   2. Caroline Dricot
   3. Tom Eilers
   4. Jelle Dillen
   5. Tim Van Rillaer
   6. Eline Cauwenberghs
   7. Ilke Van Tente
   8. Sam Bakelants
   9. Dieter Vandenheuvel
   10. Camille Allonsius
   11. Isabel Pintelon
   12. Sofie Thys
   13. Wendy Mensah
   14. Marina Naldi
   15. Peter A. Bron
   16. Stijn Wittouck
   17. Irina Spacova
   18. Carola Parolin
   19. Beatrice Vitali
   20. Sarah Lebeer

   Reviewed by Arcadia Science

4. Atf6 ^-/- mouse photoreceptors exhibit novel ciliary rootlet defect

   This article has 5 authors:

   1. Allyssa Bradley
   2. Kristen Haggerty
   3. Eun-Jin Lee
   4. Michael A. Robichaux
   5. Jonathan H. Lin

   Reviewed by Arcadia Science

5. Contrasting evolutionary forces of specialization and admixture underlie the genomic and phenotypic diversity of Yarrowia lipolytica

   This article has 9 authors:

   1. Sergio Izquierdo-Gea
   2. Javier Vicente
   3. Tomás A. Peña
   4. Pablo Villarreal
   5. Francisco A. Cubillos
   6. Cécile Neuvéglise
   7. Jorge Barriuso
   8. Ignacio Belda
   9. Javier Ruiz

   Reviewed by Arcadia Science

6. Cell cycle-dependent protein dynamics in budding yeast resolved by deconvolution of bulk proteomics

   This article has 12 authors:

   1. Andre Zylstra
   2. Mattia Rovetta
   3. Silke R. Vedelaar
   4. Christian Bleischwitz
   5. Julius A. Fülleborn
   6. Yulan van Oppen
   7. Hugo P. Markus
   8. Kerlen T. Korbeld
   9. Andreas Milias-Argeitis
   10. Katarzyna Buczak
   11. Alexander Schmidt
   12. Matthias Heinemann

   Reviewed by Arcadia Science

7. Choice of phenotype scale is critical in biobank-based G×E tests

   This article has 7 authors:

   1. Manuela Costantino
   2. Renée Fonseca
   3. Zhengtong Liu
   4. Zhenhong Huang
   5. Sriram Sankararaman
   6. Iain Mathieson
   7. Andy Dahl

   Reviewed by Arcadia Science

8. Optimizing Protein Production in the One-Pot PURE System: Insights into Reaction Composition and Expression Efficiency

   This article has 8 authors:

   1. Yan Zhang
   2. Matas Deveikis
   3. Yanping Qiu
   4. Lovisa Björn
   5. Zachary A. Martinez
   6. Tsui-Fen Chou
   7. Paul S. Freemont
   8. Richard M. Murray

   Reviewed by Arcadia Science

9. RNA foundation models enable generalizable endometriosis disease classification and stable gene-level interpretation

   This article has 14 authors:

   1. Niccolo McConnell
   2. Jennifer Kelly
   3. Ravikanth Tadikonda
   4. Natalia Mulligan
   5. Joao Bettencourt-Silva
   6. Matthew Madgwick
   7. Ritesh Krishna
   8. James Strudwick
   9. Ashley Evans
   10. Stephen Checkley
   11. Anna Paola Carrieri
   12. Michalis Smyrnakis
   13. Charles H Knowles
   14. Laura-Jayne Gardiner

   Reviewed by Arcadia Science

10. Information Geometry Reconciles Discrete and Continuous Variation in Single-Cell and Spatial Transcriptomic Analysis

    This article has 11 authors:

    1. Jinpu Cai
    2. Yuxuan Wang
    3. Yunhao Qiao
    4. Cheng Wang
    5. Ziqi Rong
    6. Luting Zhou
    7. Haoyang Liu
    8. Meng Jiang
    9. Hongbin Shen
    10. Jingyi Jessica Li
    11. Hongyi Xin

    Reviewed by Arcadia Science