Public and Global Health

Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes

1. Megan E Carey
2. Zoe A Dyson
3. Danielle J Ingle
4. Afreenish Amir
5. Mabel K Aworh
6. Marie Anne Chattaway
7. Ka Lip Chew
8. John A Crump
9. Nicholas A Feasey
10. Benjamin P Howden
11. Karen H Keddy
12. Mailis Maes
13. Christopher M Parry
14. Sandra Van Puyvelde
15. Hattie E Webb
16. Ayorinde Oluwatobiloba Afolayan
17. Anna P Alexander
18. Shalini Anandan
19. Jason R Andrews
20. Philip M Ashton
21. Buddha Basnyat
22. Ashish Bavdekar
23. Isaac I Bogoch
24. John D Clemens
25. Kesia Esther da Silva
26. Anuradha De
27. Joep de Ligt
28. Paula Lucia Diaz Guevara
29. Christiane Dolecek
30. Shanta Dutta
31. Marthie M Ehlers
32. Louise Francois Watkins
33. Denise O Garrett
34. Gauri Godbole
35. Melita A Gordon
36. Andrew R Greenhill
37. Chelsey Griffin
38. Madhu Gupta
39. Rene S Hendriksen
40. Robert S Heyderman
41. Yogesh Hooda
42. Juan Carlos Hormazabal
43. Odion O Ikhimiukor
44. Junaid Iqbal
45. Jobin John Jacob
46. Claire Jenkins
47. Dasaratha Ramaiah Jinka
48. Jacob John
49. Gagandeep Kang
50. Abdoulie Kanteh
51. Arti Kapil
52. Abhilasha Karkey
53. Samuel Kariuki
54. Robert A Kingsley
55. Roshine Mary Koshy
56. AC Lauer
57. Myron M Levine
58. Ravikumar Kadahalli Lingegowda
59. Stephen P Luby
60. Grant Austin Mackenzie
61. Tapfumanei Mashe
62. Chisomo Msefula
63. Ankur Mutreja
64. Geetha Nagaraj
65. Savitha Nagaraj
66. Satheesh Nair
67. Take K Naseri
68. Susana Nimarota-Brown
69. Elisabeth Njamkepo
70. Iruka N Okeke
71. Sulochana Putli Bai Perumal
72. Andrew J Pollard
73. Agila Kumari Pragasam
74. Firdausi Qadri
75. Farah N Qamar
76. Sadia Isfat Ara Rahman
77. Savitra Devi Rambocus
78. David A Rasko
79. Pallab Ray
80. Roy Robins-Browne
81. Temsunaro Rongsen-Chandola
82. Jean Pierre Rutanga
83. Samir K Saha
84. Senjuti Saha
85. Karnika Saigal
86. Mohammad Saiful Islam Sajib
87. Jessica C Seidman
88. Jivan Shakya
89. Varun Shamanna
90. Jayanthi Shastri
91. Rajeev Shrestha
92. Sonia Sia
93. Michael J Sikorski
94. Ashita Singh
95. Anthony M Smith
96. Kaitlin A Tagg
97. Dipesh Tamrakar
98. Arif Mohammed Tanmoy
99. Maria Thomas
100. Mathew S Thomas
101. Robert Thomsen
102. Nicholas R Thomson
103. Siaosi Tupua
104. Krista Vaidya
105. Mary Valcanis
106. Balaji Veeraraghavan
107. François-Xavier Weill
108. Jackie Wright
109. Gordon Dougan
110. Silvia Argimón
111. Jacqueline A Keane
112. David M Aanensen
113. Stephen Baker
114. Kathryn E Holt
115. Global Typhoid Genomics Consortium Group Authorship

• Curated by eLife

  eLife assessment

  Although largely descriptive, this meta-analysis of 13,000 published Typhi genomes is hugely important to public health. The dataset and presented analysis represents the first wholesale analysis of all available Typhi genomes from the last 21 years. The findings are of great significance to tracking the emergence and maintenance of AMR in Typhi and include novel insights into XDR strain emergence in Pakistan as well as the relationship between MDR maintenance and chromosomal integration.

Reviewed by eLife

Building resilient cervical cancer prevention through gender-neutral HPV vaccination

1. Irene Man
2. Damien Georges
3. Rengaswamy Sankaranarayanan
4. Partha Basu
5. Iacopo Baussano

• Curated by eLife

  eLife assessment

  This study presents valuable findings on how gender-neutral vaccination against human papillomavirus can help improve program resilience in the case of vaccination disruptions. The evidence supporting the claims of the authors is convincing, although the results are only applicable to India and other countries with a similar HPV context; researchers can adapt the model for their local context and use it as a starting point for future research.

Reviewed by eLife

Country Learning on Maintaining Quality Essential Health Services (EHS) during COVID-19 in Timor-Leste: A mixed methods qualitative analysis

1. Melissa Kleine-Bingham
2. Gregorio Rangel
3. Diana Sarakbi
4. Treasa Kelleher
5. Nana Mensah-Abrampah
6. Matthew Neilson
7. Oriane Bodson
8. Philippa White
9. Vinay Bothra
10. Helder M. de Carvalho
11. Feliciano da C.A. Pinto
12. Shamsuzzoha Babar Syed

Reviewed by PeerRef

Derivation and external validation of clinical prediction rules identifying children at risk of linear growth faltering

1. Sharia M Ahmed
2. Ben J Brintz
3. Patricia B Pavlinac
4. Lubaba Shahrin
5. Sayeeda Huq
6. Adam C Levine
7. Eric J Nelson
8. James A Platts-Mills
9. Karen L Kotloff
10. Daniel T Leung

• Curated by eLife

  eLife assessment

  This work would be of interest to global health scientists, particularly in low- and middle-income countries where childhood stunting is an ongoing challenge, and to statisticians interested in building clinical prediction rules. The authors leveraged large, rich datasets from multi-center studies to build and validate predictive models. But by using change in growth, rather than absolute growth, as the only outcome, it may be missing children of concern who are already experiencing growth failure and require intervention but have reached a growth faltering floor.

Reviewed by eLife

The impact of the COVID-19 pandemic on Italian population-based cancer screening activities and test coverage: Results from national cross-sectional repeated surveys in 2020

1. Paolo Giorgi Rossi
2. Giuliano Carrozzi
3. Patrizia Falini
4. Letizia Sampaolo
5. Giuseppe Gorini
6. Manuel Zorzi
7. Paola Armaroli
8. Carlo Senore
9. Priscilla Sassoli de Bianchi
10. Maria Masocco
11. Marco Zappa
12. Francesca Battisti
13. Paola Mantellini

• Curated by eLife

  eLife assessment

  This paper provides important evidence for the impact of the COVID-19 pandemic on cancer screening for breast, cervix, and colorectal cancer in Italy. The authors compared Invitation and examination coverage, as well as conducted telephone interviews, investigated the population screening test coverage, before and during the pandemic, according to educational attainment, perceived economic difficulties and citizenship. Their findings convincingly show that the lockdown and pandemic restrictions caused delays in screening activities but particularly increased the pre-existing individual and geographical inequalities in access.

Reviewed by eLife

An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients

1. Bronner P Gonçalves
2. Matthew Hall
3. Waasila Jassat
4. Valeria Balan
5. Srinivas Murthy
6. Christiana Kartsonaki
7. Malcolm G Semple
8. Amanda Rojek
9. Joaquín Baruch
10. Luis Felipe Reyes
11. Abhishek Dasgupta
12. Jake Dunning
13. Barbara Wanjiru Citarella
14. Mark Pritchard
15. Alejandro Martín-Quiros
16. Uluhan Sili
17. J Kenneth Baillie
18. Diptesh Aryal
19. Yaseen Arabi
20. Aasiyah Rashan
21. Andrea Angheben
22. Janice Caoili
23. François Martin Carrier
24. Ewen M Harrison
25. Joan Gómez-Junyent
26. Claudia Figueiredo-Mello
27. James Joshua Douglas
28. Mohd Basri Mat Nor
29. Yock Ping Chow
30. Xin Ci Wong
31. Silvia Bertagnolio
32. Soe Soe Thwin
33. Anca Streinu-Cercel
34. Leonardo Salazar
35. Asgar Rishu
36. Rajavardhan Rangappa
37. David SY Ong
38. Madiha Hashmi
39. Gail Carson
40. Janet Diaz
41. Rob Fowler
42. Moritz UG Kraemer
43. Evert-Jan Wils
44. Peter Horby
45. Laura Merson
46. Piero L Olliaro
47. ISARIC Clinical Characterisation Group

• Curated by eLife

  Evaluation Summary:

  This manuscript compares COVID-19 mortality during the pre-Omicron and Omicron emergence periods in several countries and finds evidence suggesting the Omicron variant was associated with lower mortality than previous dominant variants. This paper will be of interest to infectious disease scientists both for its content and its methods, as it validates that population-level variant frequency can be a good proxy for individual-level variant data to derive insights on variant biology with population data.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Lack of ownership of mobile phones could hinder the rollout of mHealth interventions in Africa

1. Justin T Okano
2. Joan Ponce
3. Matthias Krönke
4. Sally Blower

• Curated by eLife

  Evaluation Summary:

  This study used 2017-2018 Afrobarometer surveys of more than 45,000 individuals to examine the association between the ownership of mobile phones and proximity to a health clinic in 33 African countries. Findings show that about 40% of people own smartphones and those who live closer to health clinics are more likely to own a mobile phone. This manuscript will be of interest to all people who are involved in the design and implementation of mHealth interventions in Africa.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

Reviewed by eLife

Understanding disruptions in cancer care to reduce increased cancer burden

1. Kia L Davis
2. Nicole Ackermann
3. Lisa M Klesges
4. Nora Leahy
5. Callie Walsh-Bailey
6. Sarah Humble
7. Bettina Drake
8. Vetta L Sanders Thompson

• Curated by eLife

  eLife assessment

  The study presents patterns of cancer care disruption in southern Illinois and eastern Missouri in the summer of 2020. Survey results show factors that impact cancer care during the COVID-19 pandemic, including group differences by race. The important findings provide solid evidence about variation in cancer care disruptions and opportunities to improve return to care.

Reviewed by eLife

The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials

1. Yupeng Liu
2. Siyu Le
3. Yi Liu
4. Huinan Jiang
5. Binye Ruan
6. Yufeng Huang
7. Xuemei Ao
8. Xudong Shi
9. Xiaoyi Fu
10. Shuran Wang

• Curated by eLife

  Evaluation Summary:

  This is a systematic review by meta-analysis about the effect of calcium supplementation on bone health in people under 35 years old. The authors found that calcium supplementation can significantly improve BMD and BMC in young people. Moreover, a better effect of calcium supplementation was shown in people who are at the plateau of their PBM. A unique feature of this study is that it focused on people at the age before achieving PBM or age at the plateau of PBM, which is different from previous studies that mainly focused on the elderly or children.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

A comparison of sleep-wake patterns among school-age children and adolescents in Hong Kong before and during the COVID-19 pandemic

1. Steven W.H. Chau
2. Samara Hussain
3. Sandra S.M. Chan
4. Oscar W.H. Wong
5. Jihui Zhang
6. Hongliang Feng
7. Kelly Y.C. Lai
8. Suk Ling
9. Suzanne H.W. So
10. Kelvin K.F. Tsoi
11. Yun Kwok Wing
12. Se Fong Hung
13. Patrick W.L. Leung

Reviewed by ScreenIT