1. Discovery of a AHR pelargonidin agonist that counter-regulates Ace2 expression and attenuates ACE2-SARS-CoV-2 interaction

    This article has 16 authors:
    1. Michele Biagioli
    2. Silvia Marchianò
    3. Rosalinda Roselli
    4. Cristina Di Giorgio
    5. Rachele Bellini
    6. Martina Bordoni
    7. Anna Gidari
    8. Samuele Sabbatini
    9. Daniela Francisci
    10. Bianca Fiorillo
    11. Bruno Catalanotti
    12. Eleonora Distrutti
    13. Adriana Carino
    14. Angela Zampella
    15. Gabriele Costantino
    16. Stefano Fiorucci

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  2. Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro

    This article has 8 authors:
    1. Francesca Curreli
    2. Sofia M. B. Victor
    3. Shahad Ahmed
    4. Aleksandra Drelich
    5. Xiaohe Tong
    6. Chien-Te K. Tseng
    7. Christopher D. Hillyer
    8. Asim K. Debnath

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  3. Blockade of SARS-CoV-2 infection in vitro by highly potent PI3K-α/mTOR/BRD4 inhibitor

    This article has 9 authors:
    1. Arpan Acharya
    2. Kabita Pandey
    3. Michellie Thurman
    4. Kishore B. Challagundala
    5. Kendra R. Vann
    6. Tatiana G. Kutateladze
    7. Guillermo A Morales
    8. Donald L. Durden
    9. Siddappa N. Byrareddy

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  4. Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro

    This article has 8 authors:
    1. Senem Merve Fred
    2. Suvi Kuivanen
    3. Hasan Ugurlu
    4. Plinio Cabrera Casarotto
    5. Lev Levanov
    6. Kalle Saksela
    7. Olli Vapalahti
    8. Eero Castrén

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  5. Cytotoxicity Evaluation of Chloroquine and Hydroxychloroquine in Multiple Cell Lines and Tissues by Dynamic Imaging System and Physiologically Based Pharmacokinetic Model

    This article has 12 authors:
    1. Jianling Yang
    2. Zhengyang Guo
    3. Xu Liu
    4. Qi Liu
    5. Meng Wu
    6. Xueting Yao
    7. Yang Liu
    8. Cheng Cui
    9. Haiyan Li
    10. Chunli Song
    11. Dongyang Liu
    12. Lixiang Xue

    Reviewed by ScreenIT

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  6. AT-527 is a potent in vitro replication inhibitor of SARS-CoV-2, the virus responsible for the COVID-19 pandemic

    This article has 8 authors:
    1. Steven S. Good
    2. Jonna Westover
    3. Kie Hoon Jung
    4. Paolo La Colla
    5. Gabriella Collu
    6. Adel Moussa
    7. Bruno Canard
    8. Jean-Pierre Sommadossi

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  7. Computationally prioritized drugs inhibit SARS-CoV-2 infection and syncytia formation

    This article has 19 authors:
    1. Angela Serra
    2. Michele Fratello
    3. Antonio Federico
    4. Ravi Ojha
    5. Riccardo Provenzani
    6. Ervin Tasnadi
    7. Luca Cattelani
    8. Giusy del Giudice
    9. Pia A S Kinaret
    10. Laura A Saarimäki
    11. Alisa Pavel
    12. Suvi Kuivanen
    13. Vincenzo Cerullo
    14. Olli Vapalahti
    15. Peter Horvath
    16. Antonio Di Lieto
    17. Jari Yli-Kauhaluoma
    18. Giuseppe Balistreri
    19. Dario Greco

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  8. Broad-Spectrum, Patient-Adaptable Inhaled Niclosamide-Lysozyme Particles are Efficacious Against Coronaviruses in Lethal Murine Infection Models

    This article has 6 authors:
    1. Ashlee D. Brunaugh
    2. Hyojong Seo
    3. Zachary Warnken
    4. Li Ding
    5. Sang Heui Seo
    6. Hugh D.C. Smyth

    Reviewed by ScreenIT

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  9. Database for drug metabolism and comparisons, NICEdrug.ch, aids discovery and design

    This article has 6 authors:
    1. Homa MohammadiPeyhani
    2. Anush Chiappino-Pepe
    3. Kiandokht Haddadi
    4. Jasmin Hafner
    5. Noushin Hadadi
    6. Vassily Hatzimanikatis
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      In this study, the authors proposed a new web service/tool and its database, NICEdrug.ch, to be used in the fields of drug discovery and repurposing with the exploration of the metabolic fate of small molecules. The study is timely and will potentially have a high impact as metabolic evaluation of drugs/compounds is a critical topic that is still understudied.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  10. Decoding the Cure-all Effects of Ginseng

    This article has 9 authors:
    1. Shining Loo
    2. Antony Kam
    3. Bamaprasad Dutta
    4. Xiaohong Zhang
    5. Nan Feng
    6. Siu Kwan Sze
    7. Chuan-Fa Liu
    8. Xiaoliang Wang
    9. James P. Tam

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
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