Pharmacology and Toxicology

Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro

1. Dean Gilham
2. Audrey L. Smith
3. Li Fu
4. Dalia Y. Moore
5. Abenaya Muralidharan
6. St. Patrick M. Reid
7. Stephanie C. Stotz
8. Jan O. Johansson
9. Michael Sweeney
10. Norman C. W. Wong
11. Ewelina Kulikowski
12. Dalia El-Gamal

Reviewed by ScreenIT

Discovery of a AHR pelargonidin agonist that counter-regulates Ace2 expression and attenuates ACE2-SARS-CoV-2 interaction

1. Michele Biagioli
2. Silvia Marchianò
3. Rosalinda Roselli
4. Cristina Di Giorgio
5. Rachele Bellini
6. Martina Bordoni
7. Anna Gidari
8. Samuele Sabbatini
9. Daniela Francisci
10. Bianca Fiorillo
11. Bruno Catalanotti
12. Eleonora Distrutti
13. Adriana Carino
14. Angela Zampella
15. Gabriele Costantino
16. Stefano Fiorucci

Reviewed by ScreenIT

Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro

1. Francesca Curreli
2. Sofia M. B. Victor
3. Shahad Ahmed
4. Aleksandra Drelich
5. Xiaohe Tong
6. Chien-Te K. Tseng
7. Christopher D. Hillyer
8. Asim K. Debnath

Reviewed by ScreenIT

Blockade of SARS-CoV-2 infection in vitro by highly potent PI3K-α/mTOR/BRD4 inhibitor

1. Arpan Acharya
2. Kabita Pandey
3. Michellie Thurman
4. Kishore B. Challagundala
5. Kendra R. Vann
6. Tatiana G. Kutateladze
7. Guillermo A Morales
8. Donald L. Durden
9. Siddappa N. Byrareddy

Reviewed by ScreenIT

Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro

1. Senem Merve Fred
2. Suvi Kuivanen
3. Hasan Ugurlu
4. Plinio Cabrera Casarotto
5. Lev Levanov
6. Kalle Saksela
7. Olli Vapalahti
8. Eero Castrén

Reviewed by ScreenIT

Cytotoxicity Evaluation of Chloroquine and Hydroxychloroquine in Multiple Cell Lines and Tissues by Dynamic Imaging System and Physiologically Based Pharmacokinetic Model

1. Jianling Yang
2. Zhengyang Guo
3. Xu Liu
4. Qi Liu
5. Meng Wu
6. Xueting Yao
7. Yang Liu
8. Cheng Cui
9. Haiyan Li
10. Chunli Song
11. Dongyang Liu
12. Lixiang Xue

Reviewed by ScreenIT

AT-527 is a potent in vitro replication inhibitor of SARS-CoV-2, the virus responsible for the COVID-19 pandemic

1. Steven S. Good
2. Jonna Westover
3. Kie Hoon Jung
4. Paolo La Colla
5. Gabriella Collu
6. Adel Moussa
7. Bruno Canard
8. Jean-Pierre Sommadossi

Reviewed by ScreenIT

Computationally prioritized drugs inhibit SARS-CoV-2 infection and syncytia formation

1. Angela Serra
2. Michele Fratello
3. Antonio Federico
4. Ravi Ojha
5. Riccardo Provenzani
6. Ervin Tasnadi
7. Luca Cattelani
8. Giusy del Giudice
9. Pia A S Kinaret
10. Laura A Saarimäki
11. Alisa Pavel
12. Suvi Kuivanen
13. Vincenzo Cerullo
14. Olli Vapalahti
15. Peter Horvath
16. Antonio Di Lieto
17. Jari Yli-Kauhaluoma
18. Giuseppe Balistreri
19. Dario Greco

Reviewed by ScreenIT

Broad-Spectrum, Patient-Adaptable Inhaled Niclosamide-Lysozyme Particles are Efficacious Against Coronaviruses in Lethal Murine Infection Models

1. Ashlee D. Brunaugh
2. Hyojong Seo
3. Zachary Warnken
4. Li Ding
5. Sang Heui Seo
6. Hugh D.C. Smyth

Reviewed by ScreenIT

Database for drug metabolism and comparisons, NICEdrug.ch, aids discovery and design

1. Homa MohammadiPeyhani
2. Anush Chiappino-Pepe
3. Kiandokht Haddadi
4. Jasmin Hafner
5. Noushin Hadadi
6. Vassily Hatzimanikatis

• Curated by eLife

  Evaluation Summary:

  In this study, the authors proposed a new web service/tool and its database, NICEdrug.ch, to be used in the fields of drug discovery and repurposing with the exploration of the metabolic fate of small molecules. The study is timely and will potentially have a high impact as metabolic evaluation of drugs/compounds is a critical topic that is still understudied.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife