Pharmacology and Toxicology

AT-527 is a potent in vitro replication inhibitor of SARS-CoV-2, the virus responsible for the COVID-19 pandemic

1. Steven S. Good
2. Jonna Westover
3. Kie Hoon Jung
4. Paolo La Colla
5. Gabriella Collu
6. Adel Moussa
7. Bruno Canard
8. Jean-Pierre Sommadossi

Reviewed by ScreenIT

Computationally prioritized drugs inhibit SARS-CoV-2 infection and syncytia formation

1. Angela Serra
2. Michele Fratello
3. Antonio Federico
4. Ravi Ojha
5. Riccardo Provenzani
6. Ervin Tasnadi
7. Luca Cattelani
8. Giusy del Giudice
9. Pia A S Kinaret
10. Laura A Saarimäki
11. Alisa Pavel
12. Suvi Kuivanen
13. Vincenzo Cerullo
14. Olli Vapalahti
15. Peter Horvath
16. Antonio Di Lieto
17. Jari Yli-Kauhaluoma
18. Giuseppe Balistreri
19. Dario Greco

Reviewed by ScreenIT

Broad-Spectrum, Patient-Adaptable Inhaled Niclosamide-Lysozyme Particles are Efficacious Against Coronaviruses in Lethal Murine Infection Models

1. Ashlee D. Brunaugh
2. Hyojong Seo
3. Zachary Warnken
4. Li Ding
5. Sang Heui Seo
6. Hugh D.C. Smyth

Reviewed by ScreenIT

Database for drug metabolism and comparisons, NICEdrug.ch, aids discovery and design

1. Homa MohammadiPeyhani
2. Anush Chiappino-Pepe
3. Kiandokht Haddadi
4. Jasmin Hafner
5. Noushin Hadadi
6. Vassily Hatzimanikatis

• Curated by eLife

  Evaluation Summary:

  In this study, the authors proposed a new web service/tool and its database, NICEdrug.ch, to be used in the fields of drug discovery and repurposing with the exploration of the metabolic fate of small molecules. The study is timely and will potentially have a high impact as metabolic evaluation of drugs/compounds is a critical topic that is still understudied.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Decoding the Cure-all Effects of Ginseng

1. Shining Loo
2. Antony Kam
3. Bamaprasad Dutta
4. Xiaohong Zhang
5. Nan Feng
6. Siu Kwan Sze
7. Chuan-Fa Liu
8. Xiaoliang Wang
9. James P. Tam

Reviewed by PREreview

SQ3370, the first clinical click chemistry-activated cancer therapeutic, shows safety in humans and translatability across species

1. Sangeetha Srinivasan
2. Nathan A. Yee
3. Michael Zakharian
4. Maša Alečković
5. Amir Mahmoodi
6. Tri-Hung Nguyen
7. José M. Mejía Oneto

Reviewed by preLights

Selective inhibitors of JAK1 targeting a subtype-restricted allosteric cysteine

1. Madeline E. Kavanagh
2. Benjamin D. Horning
3. Roli Khattri
4. Nilotpal Roy
5. Justine P. Lu
6. Landon R. Whitby
7. Jaclyn C. Brannon
8. Albert Parker
9. Joel M. Chick
10. Christie L. Eissler
11. Ashley Wong
12. Joe L. Rodriguez
13. Socorro Rodiles
14. Kim Masuda
15. John R. Teijaro
16. Gabriel M. Simon
17. Matthew P. Patricelli
18. Benjamin F. Cravatt

Reviewed by preLights

Oxycodone decreases anxiety-like behavior in the elevated plus-maze test in male and female rats

1. Adriaan W. Bruijnzeel
2. Azin Behnood-Rod
3. Wendi Malphurs
4. Ranjithkumar Chellian
5. Robert M. Caudle
6. Marcelo Febo
7. Barry Setlow
8. John K. Neubert

Reviewed by preLights

Discovery and Visualization of Uncharacterized Drug–Protein Adducts Using Mass Spectrometry

1. Michael Riffle
2. Michael R. Hoopmann
3. Daniel Jaschob
4. Guo Zhong
5. Robert L. Moritz
6. Michael J. MacCoss
7. Trisha N. Davis
8. Nina Isoherranen
9. Alex Zelter

Reviewed by preLights

Tamoxifen reduces inflammatory infiltration of neutrophils in the airways

1. Agustín Mansilla
2. Jaime Soto
3. Claudio Henríquez
4. Amber Philp
5. Marcus A. Mall
6. José Sarmiento
7. Carlos A. Flores

Reviewed by preLights