1. Disease modeling and pharmacological rescue of autosomal dominant retinitis pigmentosa associated with RHO copy number variation

    This article has 8 authors:
    1. Sangeetha Kandoi
    2. Cassandra Martinez
    3. Kevin Xu Chen
    4. Miika Mehine
    5. L Vinod K Reddy
    6. Brian C Mansfield
    7. Jacque L Duncan
    8. Deepak A Lamba
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents an important finding that implicates a rhodopsin gene duplication in the progression of autosomal dominant retinitis pigmentosa in patients. The authors utilize a retinal organoid model to demonstrate a similar disease phenotype and suggest defects can be ameliorated by using photoregulin. The data supporting the conclusions are solid, but there are some concerns regarding the strength of the phenotype in retinal organoids. This work will be of broad interest to vision researchers.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  2. Defective CAPSL function causes impaired retinal angiogenesis through the MYC axis and is associated with familial exudative vitreoretinopathy

    This article has 11 authors:
    1. Wenjing Liu
    2. Shujin Li
    3. Mu Yang
    4. Jie Ma
    5. Lu Liu
    6. Ping Fei
    7. Qianchun Xiang
    8. Lulin Huang
    9. Peiquan Zhao
    10. Zhenglin Yang
    11. Xianjun Zhu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study explores the role of calcyphosine-like (CAPSL) in Familial Exudative Vitreoretinopathy (FEVR) via the MYC pathway, offering valuable insights into disease mechanisms that are supported by a solid, multi-pronged approach. The overall significance of the study might, however, be limited due to weak support from human genetic studies.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Metabolomics identifies and validates serum androstenedione as novel biomarker for diagnosing primary angle closure glaucoma and predicting the visual field progression

    This article has 11 authors:
    1. Shengjie Li
    2. Jun Ren
    3. Zhendong Jiang
    4. Yichao Qiu
    5. Mingxi Shao
    6. Yingzhu Li
    7. Jianing Wu
    8. Yunxiao Song
    9. Xinghuai Sun
    10. Shunxiang Gao
    11. Wenjun Cao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable finding that serum androstenedione levels may provide a new biomarker for early detection and progression of glaucoma, although a single biomarker is unlikely to be singularly predictive due to the etiological heterogeneity of the disease. The strength of the evidence presented is solid, supported by multiple lines of evidence.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  4. The Prevalence of ocular manifestations and ocular samples polymerase chain reaction positivity in patients with COVID 19 - a systematic review and meta-analysis

    This article has 5 authors:
    1. Soumen Sadhu
    2. Sushmitha Arcot Dandapani
    3. Deepmala Mazumdar
    4. Sangeetha Srinivasan
    5. Jyotirmay Biswas

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  5. Type and frequency of ocular and other known symptoms experienced by people who self–diagnosed as suffering from COVID-19 in the UK

    This article has 5 authors:
    1. Shahina Pardhan
    2. Megan Vaughan
    3. Jufen Zhang
    4. Lee Smith
    5. Havovi Chichger

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  6. Knowledge and awareness-based survey of COVID-19 within the eye care profession in Nepal: Misinformation is hiding the truth

    This article has 5 authors:
    1. Sandip Das Sanyam
    2. Sanjay Kumar Sah
    3. Pankaj Chaudhary
    4. Matthew J. Burton
    5. Jeremy J. Hoffman

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  7. Estimating excess visual loss from neovascular age-related macular degeneration in the UK during the COVID-19 pandemic: a retrospective clinical audit and simulation model

    This article has 14 authors:
    1. Darren S Thomas
    2. Alasdair Warwick
    3. Abraham Olvera-Barrios
    4. Catherine Egan
    5. Roy Schwartz
    6. Sudeshna Patra
    7. Haralabos Eleftheriadis
    8. Anthony Khawaja
    9. Andrew Lotery
    10. Philipp L Muller
    11. Robin Hamilton
    12. Ella Preston
    13. Paul Taylor
    14. Adnan Tufail

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  8. Assessing visible aerosol generation during vitrectomy in the era of Covid-19

    This article has 6 authors:
    1. Sidath Liyanage
    2. Pathma Ramasamy
    3. Omar Elhaddad
    4. Kieren Darcy
    5. Andrew Hudson
    6. Johannes Keller

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  9. SARS-CoV-2 receptor ACE2 is expressed in human conjunctival tissue, especially in diseased conjunctival tissue

    This article has 7 authors:
    1. Shengjie Li
    2. Danhui Li
    3. Jianchen Fang
    4. Qiang Liu
    5. Wenjun Cao
    6. Xinghuai Sun
    7. Gezhi Xu

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  10. Proof‐of‐concept calculations to determine the health‐adjusted life‐year trade‐off between intravitreal anti‐VEGF injections and transmission of COVID ‐19

    This article has 4 authors:
    1. Matt J. Boyd
    2. Daniel A. R. Scott
    3. David M. Squirrell
    4. Graham A. Wilson

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity