Ophthalmology

Ocular biomarker profiling after complement factor I gene therapy in geographic atrophy secondary to age-related macular degeneration

1. Thomas M Hallam
2. Emanuela Gardenal
3. Fraser McBlane
4. GaEun Cho
5. Lucy Lee Ferraro
6. Eva Pekle
7. Darlene Lu
8. Kate Carney
9. Claire Wenden
10. Hannah Beadsmoore
11. Sergio Kaiser
12. Lauren Drage
13. Thomas Haye
14. Iris Kassem
15. Nalini Rangaswamy
16. Ma’en Obeidat
17. Cyndy Grosskreutz
18. Magali Saint-Geniez
19. David H Steel
20. Robert E MacLaren
21. Scott Ellis
22. Claire L Harris
23. Stephen Poor
24. Amy V Jones

• Curated by eLife

  eLife assessment

  This important work advances our understanding of factors influencing efficacy assessments and biomarker viability for complement-directed gene therapy against age-related macular degeneration. The data presented is convincing and offers insights and teachings for the design of gene therapy and complement-targeted therapeutics in the eye and more broadly for future ocular biomarker studies.

Reviewed by eLife

Defective CAPSL function causes impaired retinal angiogenesis through the MYC axis and is associated with familial exudative vitreoretinopathy

1. Wenjing Liu
2. Shujin Li
3. Mu Yang
4. Jie Ma
5. Lu Liu
6. Ping Fei
7. Qianchun Xiang
8. Lulin Huang
9. Peiquan Zhao
10. Zhenglin Yang
11. Xianjun Zhu

• Curated by eLife

  eLife assessment

  This study explores the role of calcyphosine-like (CAPSL) in Familial Exudative Vitreoretinopathy (FEVR) via the MYC pathway, offering valuable insights into disease mechanisms that are supported by a solid, multi-pronged approach. The manuscript, which presents the phenotype of an interesting new mouse model, provides convincing evidence that CAPSL variants cause disease.

Reviewed by eLife

Disease modeling and pharmacological rescue of autosomal dominant retinitis pigmentosa associated with RHO copy number variation

1. Sangeetha Kandoi
2. Cassandra Martinez
3. Kevin Xu Chen
4. Miika Mehine
5. L Vinod K Reddy
6. Brian C Mansfield
7. Jacque L Duncan
8. Deepak A Lamba

• Curated by eLife

  eLife assessment

  This study presents an important finding that implicates a rhodopsin gene duplication in the progression of autosomal dominant retinitis pigmentosa in patients. The authors utilize a retinal organoid model to demonstrate a similar disease phenotype and suggest defects can be ameliorated by using photoregulin. The data supporting the conclusions are solid, but there are some concerns regarding the strength of the phenotype in retinal organoids. This work will be of broad interest to vision researchers.

Reviewed by eLife

Metabolomics identifies and validates serum androstenedione as novel biomarker for diagnosing primary angle closure glaucoma and predicting the visual field progression

1. Shengjie Li
2. Jun Ren
3. Zhendong Jiang
4. Yichao Qiu
5. Mingxi Shao
6. Yingzhu Li
7. Jianing Wu
8. Yunxiao Song
9. Xinghuai Sun
10. Shunxiang Gao
11. Wenjun Cao

• Curated by eLife

  eLife assessment

  This study presents a valuable finding that serum androstenedione levels may provide a new biomarker for early detection and progression of glaucoma, although a single biomarker is unlikely to be singularly predictive due to the etiological heterogeneity of the disease. The strength of the evidence presented is solid, supported by multiple lines of evidence.

Reviewed by eLife

The Prevalence of ocular manifestations and ocular samples polymerase chain reaction positivity in patients with COVID 19 - a systematic review and meta-analysis

1. Soumen Sadhu
2. Sushmitha Arcot Dandapani
3. Deepmala Mazumdar
4. Sangeetha Srinivasan
5. Jyotirmay Biswas

Reviewed by ScreenIT

Type and frequency of ocular and other known symptoms experienced by people who self–diagnosed as suffering from COVID-19 in the UK

1. Shahina Pardhan
2. Megan Vaughan
3. Jufen Zhang
4. Lee Smith
5. Havovi Chichger

Reviewed by ScreenIT

Knowledge and awareness-based survey of COVID-19 within the eye care profession in Nepal: Misinformation is hiding the truth

1. Sandip Das Sanyam
2. Sanjay Kumar Sah
3. Pankaj Chaudhary
4. Matthew J. Burton
5. Jeremy J. Hoffman

Reviewed by ScreenIT

Estimating excess visual loss from neovascular age-related macular degeneration in the UK during the COVID-19 pandemic: a retrospective clinical audit and simulation model

1. Darren S Thomas
2. Alasdair Warwick
3. Abraham Olvera-Barrios
4. Catherine Egan
5. Roy Schwartz
6. Sudeshna Patra
7. Haralabos Eleftheriadis
8. Anthony Khawaja
9. Andrew Lotery
10. Philipp L Muller
11. Robin Hamilton
12. Ella Preston
13. Paul Taylor
14. Adnan Tufail

Reviewed by ScreenIT

Assessing visible aerosol generation during vitrectomy in the era of Covid-19

1. Sidath Liyanage
2. Pathma Ramasamy
3. Omar Elhaddad
4. Kieren Darcy
5. Andrew Hudson
6. Johannes Keller

Reviewed by ScreenIT

SARS-CoV-2 receptor ACE2 is expressed in human conjunctival tissue, especially in diseased conjunctival tissue

1. Shengjie Li
2. Danhui Li
3. Jianchen Fang
4. Qiang Liu
5. Wenjun Cao
6. Xinghuai Sun
7. Gezhi Xu

Reviewed by ScreenIT