Neuroscience

Hippocampal estrogen levels, receptor types, and epigenetics contribute to sex-specific memory vulnerabilities to concurrent acute stresses

1. Rachael E. Hokenson
2. Kiara L. Rodríguez-Acevedo
3. Yuncai Chen
4. Annabel K. Short
5. Sara A. Samrari
6. Brinda Devireddy
7. Brittany J. Jensen
8. Julia J. Winter
9. Christine M. Gall
10. Kiran K. Soma
11. Elizabeth A. Heller
12. Tallie Z. Baram

Reviewed by preLights

Specificity Protein 1 is essential for the limb trajectory of ephrin-mediated spinal motor axons

1. Pinwen Liao
2. Ming-Yuan Chang
3. Wen-Bin Yang
4. Keefer Lin
5. Yi-Chao Li
6. Jian-Ying Chuang
7. Yi-Hsin Wu
8. Artur Kania
9. Wen-Chang Chang
10. Tsung-I Hsu
11. Tzu-Jen Kao

• Curated by eLife

  eLife Assessment

  This study makes an important contribution to the molecular mechanisms of neural circuit formation. The data convincingly show that the transcription factor Sp1 regulates ephrin-mediated axon guidance in the spinal cord. Although the authors show that Sp1 and its co-activators p300 and CBP are required to induce ephrin expression, additional discussion and/or experiments are needed to support the claims that Sp1 regulates cis-binding of Epha receptors, or that Sp1 controls ephrin expression in relevant motor neuron populations. The study will be of broad interest to developmental neurobiologists.

Reviewed by eLife

Master control genes in the regeneration of rod photoreceptors from endogenous progenitor cells in zebrafish retina

1. Eyad Shihabeddin
2. Abirami Santhanam
3. Stephan Tetenborg
4. Alexandra L Aronowitz
5. Haichao Wei
6. Guoting Qin
7. Chengzhi Cai
8. Jiaqian Wu
9. John O’Brien

• Curated by eLife

  eLife Assessment

  Shihabeddin et al utilized single-cell RNA-Seq analysis of adult P23H zebrafish animals to identify transcription factors (e2fs, Prdm1a, Sp1) expressed selectively in neural progenitors and immature rods, and validated their necessity for regeneration using morphant analysis. The finding is useful, and the evidence is convincing. The deeper mechanistic analysis could further strengthen the current work by (1) distinguishing developmental vs regenerative transcriptional factors, (2) the addition of matched scATAC-Seq data, and (3) integration with single-cell multiome data from developing retina.

Reviewed by eLife