Neuroscience

Zinc finger homeobox-3 (ZFHX3) orchestrates genome-wide daily gene expression in the suprachiasmatic nucleus

1. Akanksha Bafna
2. Gareth Banks
3. Vadim Vasilyev
4. Robert Dallmann
5. Michael H Hastings
6. Patrick M Nolan

• Curated by eLife

  eLife Assessment

  This is an important study that generates an inventory of accessible genomic regions bound by a transcription factor ZFHX3 within the suprachiasmatic nucleus in the hypothalamus and details the impact of its depletion on daily rhythms in behavior and gene expression patterns. Analysis using circadian phase-estimation algorithms makes the argument that gene regulatory networks are at play and changes in gene expression of a few clock genes cannot account for the observed animal behaviour. While the transcriptome analysis is compelling, the data on the activity of the TF in rhythmic gene expression is solid, and interpretations that allow for direct and/or indirect roles have been incorporated.

Reviewed by eLife

Olfactory bulb tracks breathing rhythms and place in freely behaving mice

1. Scott C Sterrett
2. Teresa M Findley
3. Sidney E Rafilson
4. Morgan A Brown
5. Aldis P Weible
6. Rebecca Marsden
7. Takisha Tarvin
8. Michael Wehr
9. James M Murray
10. Adrienne L Fairhall
11. Matthew C Smear

• Curated by eLife

  eLife Assessment

  This is an important study linking olfactory bulb activity not only to sniffing parameters but also to movement and place. The evidence for odor sampling is mostly solid, but the analysis supporting the potentially exciting result on the encoding of place is currently incomplete.

Reviewed by eLife

Selective autophagy fine-tunes Stat92E activity by degrading Su(var)2-10/PIAS during glial injury signaling in Drosophila

1. Virág Vincze
2. Zsombor Esküdt
3. Erzsébet Fehér-Juhász
4. Aishwarya Sanjay Chhatre
5. András Jipa
6. Martin Csordós
7. Anna Rita Galambos
8. Dalma Feil-Börcsök
9. Gábor Juhász
10. Áron Szabó

Reviewed by Review Commons

Structure transfer and consolidation in visual implicit learning

1. Dominik Garber
2. József Fiser

• Curated by eLife

  eLife Assessment

  This study investigates the conditions under which abstract knowledge transfers to new learning. It presents convincing evidence across a number of behavioral experiments that when explicit awareness of learned statistical structure is present, knowledge can transfer immediately, but that otherwise similar transfer requires sleep-dependent consolidation. The valuable results provide new constraints on theories of transfer learning and consolidation.

Reviewed by eLife

Comparative fMRI reveals differences in the functional organization of the visual cortex for animacy perception in dogs and humans

1. Eszter Borbála Farkas
2. Raúl Hernández-Pérez
3. Laura Veronica Cuaya
4. Eduardo Rojas-Hortelano
5. Márta Gácsi
6. Attila Andics

• Curated by eLife

  eLife Assessment

  This useful study presents a comparative investigation of category selectivity in dogs and humans. The study compares brain representations of animate and inanimate objects, replicating and extending previous reports in this nascent field of dog FMRI. The methods and results seem to lack sufficient detail, appropriate controls, or statistical evidence, so at this stage of the review process, the strength of evidence is deemed incomplete.

Reviewed by eLife

Task‐specific topology of brain networks supporting working memory and inhibition

1. Timofey Adamovich
2. Victoria Ismatullina
3. Nadezhda Chipeeva
4. Ilya Zakharov
5. Inna Feklicheva
6. Sergey Malykh

Reviewed by PREreview

MLCK/MLCP regulates mammalian axon regeneration and redistributes the growth cone F-actin

1. Saijilafu
2. Wei-Hua Wang
3. Jin-Jin Ma
4. Yin Yin
5. Yan-Xia Ma

• Curated by eLife

  eLife Assessment

  Saijilafu et al. describe valuable findings suggesting that MLCK and MLCP bidirectionally regulate NMII phosphorylation ultimately impinging on axonal growth during regeneration in the central and peripheral nervous systems. Solid evidence is collected from culture and in vivo models, and through pharmacologic and genetic loss-of-function approaches. However, how MLCK and MLCP regulates NMII activity is not fully addressed or discussed. In sum, this knowledge is of potential interest for the field due to the relevance of identifying mechanistic details that regulate axonal regeneration

Reviewed by eLife

A novel method (RIM-Deep) for enhancing imaging depth and resolution stability of deep cleared tissue in inverted confocal microscopy

1. Yisi Liu
2. Pu Wang
3. Junjie Zou
4. Hongwei Zhou

• Curated by eLife

  eLife Assessment

  This study describes a useful technique to improve imaging depth using confocal microscopy for imaging large, cleared samples. The work is supported by solid findings and will be of broad interest to many microscopical researchers in different fields who want a cost effective way to image deep into samples.

Reviewed by eLife

Pervasive neurovascular dysfunction in the ventromedial prefrontal cortex of female depressed suicides with a history of childhood abuse

1. Marina Wakid
2. Daniel Almeida
3. Ryan Denniston
4. Anjali Chawla
5. Zahia Aouabed
6. Maria Antonietta Davoli
7. Kristin Ellerbeck
8. Reza Rahimian
9. Volodymyr Yerko
10. Elena Leonova-Erko
11. Gustavo Turecki
12. Naguib Mechawar

Reviewed by PREreview

Enhanced neural speech tracking through noise indicates stochastic resonance in humans

1. Björn Herrmann

• Curated by eLife

  eLife Assessment

  This study presents an important contribution to the understanding of neural speech tracking, demonstrating how minimal background noise can enhance the neural tracking of the amplitude-onset envelope. The evidence, through a well-designed series of EEG experiments, is convincing. This work will be of interest to auditory scientists, particularly those investigating biological markers of speech processing.

Reviewed by eLife