Neuroscience

Efficient Generation of Expandable Dorsal Forebrain Neural Rosette Stem Cell Lines

1. Signe Emilie Dannulat Frazier
2. Kristian Honnens de Lichtenberg
3. Elham Jaberi
4. Charlotte Bertelsen
5. Simone Møller Jensen
6. Andreas Wrona
7. Nicolaj Strøyer Christophersen
8. Mie Kristensen
9. J Carlos Villaescusa

• Curated by eLife

  eLife Assessment

  The study provides valuable technical advances to generate and isolate neural rosettes. The technique is robust, as indicated by both reviewers. The evidence is solid, as shown in orthogonal characterization by flow cytometry, morphology, and scRNA-seq. Comparison with the manual-rosette-picking protocol will enhance the validity of the claims.

Reviewed by eLife

Intrinsic Resistance of the Hippocampal CA2 Subfield to Neuroinflammation After Status Epilepticus

1. Bruno Ponciano Da silva
2. Edna Cristina Santos Franco
3. Silene Maria Araújo de Lima

Reviewed by PREreview

Passive muscle forces in Drosophila are large but insufficient to support a fly’s weight

1. Ninghan Wang
2. Helene Babski
3. Jonathan Elliot Perdomo
4. Sarah Beth McMahan
5. Arun Ramakrishnan
6. Tirthabir Biswas
7. Vikas Bhandawat

• Curated by eLife

  eLife Assessment

  This valuable study introduces a novel experimental and modeling framework to quantify passive joint torques in Drosophila, revealing that passive forces are insufficient to support body weight, contrary to prior assumptions based on larger insects. The approach is technically impressive, combining genetic silencing, kinematic tracking, and biomechanical modeling. However, the strength of evidence is incomplete, limited by concerns about the specificity of the genetic tools, simplifications in the mechanical model, and limited functional interpretation.

Reviewed by eLife

Unveiling distinct neuroimmune responses in mouse models of cervical spinal cord injury: Hemisection versus hemicontusion

1. Wei Chen
2. Lucille Adam
3. Pauline Michel-Flutot
4. Arnaud Mansart
5. Stéphane Vinit
6. Isabelle Vivodtzev

Reviewed by Arcadia Science