1. Polystyrene nanoplastics promote neurodegeneration by catalyzing TDP43 hyperphosphorylation

    This article has 13 authors:
    1. Winanto
    2. Li-Yi Tan
    3. Wai Hon Chooi
    4. Cheryl Yi-Pin Lee
    5. Wan Yun Ho
    6. Yong Shan Lim
    7. Boon Seng Soh
    8. Emma Sanford
    9. Chong-Lun Tan
    10. Yih-Cherng Liou
    11. Cathy Chia-Yu Huang
    12. Shuo-Chien Ling
    13. Shi-Yan Ng

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  2. Spatial localization of hippocampal replay requires dopamine signaling

    This article has 2 authors:
    1. Matthew R Kleinman
    2. David J Foster
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This work provides a valuable contribution to our understanding of the neurobiological mechanisms underlying spatial memory and learning, suggesting that dopamine plays a pivotal role in linking reward context and novelty to memory consolidation processes. The evidence presented to support the main conclusions is solid, although reviewers felt that the strength of evidence could have been further strengthened by more rigorous histological verification of the experimental conditions and the complexity of the experimental manipulations, increased sample sizes, and a more consistent approach to experimental dosing and timing, which will be crucial for confirming the reproducibility and reliability of the observed effects.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  3. Endopiriform neurons projecting to ventral CA1 are a critical node for recognition memory

    This article has 9 authors:
    1. Naoki Yamawaki
    2. Hande Login
    3. Solbjørg Østergaard Feld-Jakobsen
    4. Bernadett Mercedesz Molnar
    5. Mads Zippor Kirkegaard
    6. Maria Moltesen
    7. Aleksandra Okrasa
    8. Jelena Radulovic
    9. Asami Tanimura
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study offers insights into the function and connectivity patterns of a relatively unknown afferent input from the endopiriform to the CA1 subfield of the ventral hippocampus, suggesting a neural mechanism that suppresses the processing of familiar stimuli in favor of detecting memory guided novelty. The strength of evidence is convincing, with careful anatomical and electrophysiological circuit characterization. The work will be of broad interest to researchers studying the neural circuitry of behavior.

    Reviewed by eLife

    This article has 11 evaluationsAppears in 1 listLatest version Latest activity
  4. Basal ganglia output (entopeduncular nucleus) coding of contextual kinematics and reward in the freely moving mouse

    This article has 4 authors:
    1. Anil K Verma Rodriguez
    2. Josue O Ramírez-Jarquin
    3. Román Rossi-Pool
    4. Fatuel Tecuapetla
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study reports on electrophysiological recording of the spiking activity of single neurons in the entopeduncular nucleus (EPN) in freely-moving mice performing an auditory discrimination task. The data show that the activity of single EPN neurons is modulated by reward and movement kinematics, with the latter further affected by task contexts (e.g. movement toward or away from a reward location). The results provide solid evidence for the conclusions. There is some ambiguity as to whether the data contain the population of EPN neurons characterized in previous studies that obtained different results. Investigations separating confounding factors would be of benefit. Nonetheless, the work is overall of interest to those who study how the basal ganglia, particularly the EPN, contribute to behavior.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  5. An anatomical and physiological basis for flexible coincidence detection in the auditory system

    This article has 6 authors:
    1. Lauren J Kreeger
    2. Suraj Honnuraiah
    3. Sydney Maeker
    4. Siobhan Shea
    5. Gordon Fishell
    6. Lisa Goodrich
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Kreeger et al. convincingly demonstrate that octopus cells in the mouse cochlear nucleus, previously thought to rely primarily on excitatory inputs for coincidence detection, also receive glycinergic inhibitory synaptic inputs that influence their synaptic integration. Using advanced techniques, including genetic mouse models, optogenetics, microscopy, slice physiology, and computational modeling, this important study reveals that inhibition can shunt synaptic currents and alter the timing of dendritic EPSPs, both of which are significant for auditory processing. This research broadens the understanding of octopus cells' roles in sensory processing, highlighting the importance of inhibitory inputs in shaping fast, high-frequency neural response capabilities.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  6. Movies reveal the fine-grained organization of infant visual cortex

    This article has 4 authors:
    1. Cameron T Ellis
    2. Tristan S Yates
    3. Michael J Arcaro
    4. Nicholas Turk-Browne
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents valuable evidence concerning the potential for naturalistic movie-viewing fMRI experiments to reveal some features that are correlated with the functional and topographical organization of the developing visual system in awake infants and toddlers. The data are compelling given the difficulty of studying this population, the methodology is original and validated, and the evidence supporting the conclusions is convincing and in line with prior research using resting-state and awake task-based fMRI. This study will be of interest to cognitive neuroscientists and developmental psychologists, and in particular those interested in using fMRI to investigate brain organisation in pediatric and clinical populations with limited tolerance to fMRI.

    Reviewed by eLife

    This article has 13 evaluationsAppears in 1 listLatest version Latest activity
  7. Control of innate olfactory valence by segregated cortical amygdala circuits

    This article has 12 authors:
    1. James R Howe
    2. Chung-Lung Chan
    3. Donghyung Lee
    4. Marlon Blanquart
    5. James H Lee
    6. Haylie K Romero
    7. Abigail N Zadina
    8. Mackenzie E Lemieux
    9. Fergil Mills
    10. Paula A Desplats
    11. Kay M Tye
    12. Cory M Root
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides important insights into how a specific brain region controls innate responses to odors, showing that different parts of this region govern behaviors related to attraction and aversion. The findings are convincing and supported by a combination of well-executed experimental approaches, including genetic manipulations and neural activity mapping, though the evidence could be strengthened by addressing certain methodological concerns, such as clarifying the rationale for specific experimental choices and exploring alternative techniques.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  8. CaBLAM! A high-contrast bioluminescent Ca 2+ indicator derived from an engineered Oplophorus gracilirostris luciferase

    This article has 34 authors:
    1. Gerard G. Lambert
    2. Emmanuel L. Crespo
    3. Jeremy Murphy
    4. Kevin Turner
    5. Emily Gershowitz
    6. Michaela Cunningham
    7. Daniela Boassa
    8. Selena Luong
    9. Dmitrijs Celinskis
    10. Justine J. Allen
    11. Stephanie Venn
    12. Yunlu Zhu
    13. Mürsel Karadas
    14. Jiakun Chen
    15. Roberta Marisca
    16. Hannah Gelnaw
    17. Daniel K. Nguyen
    18. Junru Hu
    19. Brittany N. Sprecher
    20. Maya O. Tree
    21. Richard Orcutt
    22. Daniel Heydari
    23. Aidan B. Bell
    24. Albertina Torreblanca-Zanca
    25. Ali Hakimi
    26. Tim Czopka
    27. Shy Shoham
    28. Katherine I. Nagel
    29. David Schoppik
    30. Arturo Andrade
    31. Diane Lipscombe
    32. Christopher I. Moore
    33. Ute Hochgeschwender
    34. Nathan C. Shaner

    Reviewed by Arcadia Science

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  9. Cholinergic waves have a modest influence on the transcriptome of retinal ganglion cells

    This article has 4 authors:
    1. Rachana Deven Somaiya
    2. Matthew A. Po
    3. Marla B. Feller
    4. Karthik Shekhar

    Reviewed by Arcadia Science

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  10. A split-GAL4 driver line resource for Drosophila neuron types

    This article has 84 authors:
    1. Geoffrey W Meissner
    2. Allison Vannan
    3. Jennifer Jeter
    4. Kari Close
    5. Gina M DePasquale
    6. Zachary Dorman
    7. Kaitlyn Forster
    8. Jaye Anne Beringer
    9. Theresa Gibney
    10. Joanna H Hausenfluck
    11. Yisheng He
    12. Kristin Henderson
    13. Lauren Johnson
    14. Rebecca M Johnston
    15. Gudrun Ihrke
    16. Nirmala A Iyer
    17. Rachel Lazarus
    18. Kelley Lee
    19. Hsing-Hsi Li
    20. Hua-Peng Liaw
    21. Brian Melton
    22. Scott Miller
    23. Reeham Motaher
    24. Alexandra Novak
    25. Omotara Ogundeyi
    26. Alyson Petruncio
    27. Jacquelyn Price
    28. Sophia Protopapas
    29. Susana Tae
    30. Jennifer Taylor
    31. Rebecca Vorimo
    32. Brianna Yarbrough
    33. Kevin Xiankun Zeng
    34. Christopher T Zugates
    35. Heather Dionne
    36. Claire Angstadt
    37. Kelly Ashley
    38. Amanda Cavallaro
    39. Tam Dang
    40. Guillermo A Gonzalez
    41. Karen L Hibbard
    42. Cuizhen Huang
    43. Jui-Chun Kao
    44. Todd Laverty
    45. Monti Mercer
    46. Brenda Perez
    47. Scarlett Rose Pitts
    48. Danielle Ruiz
    49. Viruthika Vallanadu
    50. Grace Zhiyu Zheng
    51. Cristian Goina
    52. Hideo Otsuna
    53. Konrad Rokicki
    54. Robert R Svirskas
    55. Han SJ Cheong
    56. Michael-John Dolan
    57. Erica Ehrhardt
    58. Kai Feng
    59. Basel EI Galfi
    60. Jens Goldammer
    61. Stephen J Huston
    62. Nan Hu
    63. Masayoshi Ito
    64. Claire McKellar
    65. Ryo Minegishi
    66. Shigehiro Namiki
    67. Aljoscha Nern
    68. Catherine E Schretter
    69. Gabriella R Sterne
    70. Lalanti Venkatasubramanian
    71. Kaiyu Wang
    72. Tanya Wolff
    73. Ming Wu
    74. Reed George
    75. Oz Malkesman
    76. Yoshinori Aso
    77. Gwyneth M Card
    78. Barry J Dickson
    79. Wyatt Korff
    80. Kei Ito
    81. James W Truman
    82. Marta Zlatic
    83. Gerald M Rubin
    84. FlyLight Project Team
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study presents a resource for researchers using Drosophila to study neural circuits, in the form of a collection of split-Gal4 lines with an online search engine, which will facilitate the mapping of neuronal circuits. The evidence is convincing to demonstrate the utility of these new tools, and of the search engine, for understanding expression patterns in adults and larvae, and differences between the sexes. These resources will be of broad interest to Drosophila researchers in the field of neurobiology.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
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